amantadine and Coma
amantadine has been researched along with Coma in 14 studies
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " Methylphenidate and amantadine have treated coma in traumatically-brain-injured patients with mixed success, but have not been explored in post-arrest patients." | 7.79 | Methylphenidate and amantadine to stimulate reawakening in comatose patients resuscitated from cardiac arrest. ( Callaway, CW; Reynolds, JC; Rittenberger, JC, 2013) |
| "1,3-Dimethyl-5-aminoadamantane (DMAA, D-145, memantine, Memantine) was used in a group of 25 patients of both sexes in coma and with brain stem symptoms for symptomatic therapy." | 7.66 | [Valve of symptomatic therapy with memantine in cerebral coma. II. Development of stretch synergisms in coma with brain stem symptoms]. ( Miltner, FO, 1982) |
| "The results of our study will help to systematically assess the clinical utility of amantadine for treatment of persisting coma in non-traumatic brain injury." | 5.69 | Amantadine for NeuroenhaNcement in acutE patients Study - a protocol for a prospective pilot proof of concept phase IIb study in intensive and intermediate care unit patients (ANNES). ( Adeyemi, K; Blum, C; Bösel, R; Brendel, B; Feil, K; Häberle, HA; Haug, I; Hofmann, A; Martus, P; Mengel, A; Rattay, TW; Riessen, R; Schwarz, P; Single, C; Siokas, V; Zago, M; Ziemann, U, 2023) |
| "Amantadine toxicity is a particular problem in patients with renal insufficiency because 90% of an oral dose is excreted unchanged in the urine." | 5.29 | Amantadine-induced coma. ( Ito, V; Macchio, GJ; Sahgal, V, 1993) |
| "The significant improvement of coma stages 2 and 3 already during the treatment with memantine should be emphasized." | 5.26 | [Valve of symptomatic therapy with memantine in cerebral coma. I. Correlation with coma stages and EEG spectral patterns]. ( Miltner, FO, 1982) |
| "We propose that a combination of levetiracetam and amantadine may provide neuroprotective and neurorestorative properties when administered during a period of hyperpyrexia accompanied by any form of mental status changes, particularly if there is a decline in Glasgow Coma Score." | 3.85 | Preserving brain function in a comatose patient with septic hyperpyrexia (41.6 °C): a case report. ( Akinyemi, A; Michel, G; Sanchez-Gonzalez, MA; Sterkel, S, 2017) |
| " Methylphenidate and amantadine have treated coma in traumatically-brain-injured patients with mixed success, but have not been explored in post-arrest patients." | 3.79 | Methylphenidate and amantadine to stimulate reawakening in comatose patients resuscitated from cardiac arrest. ( Callaway, CW; Reynolds, JC; Rittenberger, JC, 2013) |
| "1,3-Dimethyl-5-aminoadamantane (DMAA, D-145, memantine, Memantine) was used in a group of 25 patients of both sexes in coma and with brain stem symptoms for symptomatic therapy." | 3.66 | [Valve of symptomatic therapy with memantine in cerebral coma. II. Development of stretch synergisms in coma with brain stem symptoms]. ( Miltner, FO, 1982) |
| "Optimizing the recovery from coma is a priority in seeking to improve patients' functional outcomes." | 2.50 | Therapeutic options to enhance coma arousal after traumatic brain injury: state of the art of current treatments to improve coma recovery. ( Cossu, G, 2014) |
| "Influenza encephalopathy typically is associated with a sudden onset of high fever, severe convulsions, rapidly progressive coma, and death within 2 or 3 days." | 2.41 | Influenza-associated encephalopathy in Japan. ( Sugaya, N, 2002) |
| "Treatment included induction of coma while a native immune response matured; rabies vaccine was not administered." | 1.33 | Survival after treatment of rabies with induction of coma. ( Amlie-Lefond, CM; Chusid, MJ; Ghanayem, NS; Hoffman, GM; Rupprecht, CE; Schwabe, MJ; Tieves, KS; Willoughby, RE, 2005) |
| "Amantadine toxicity is a particular problem in patients with renal insufficiency because 90% of an oral dose is excreted unchanged in the urine." | 1.29 | Amantadine-induced coma. ( Ito, V; Macchio, GJ; Sahgal, V, 1993) |
| "The significant improvement of coma stages 2 and 3 already during the treatment with memantine should be emphasized." | 1.26 | [Valve of symptomatic therapy with memantine in cerebral coma. I. Correlation with coma stages and EEG spectral patterns]. ( Miltner, FO, 1982) |
Research
Studies (14)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (28.57) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Hofmann, A | 1 |
| Blum, C | 1 |
| Single, C | 1 |
| Adeyemi, K | 1 |
| Schwarz, P | 1 |
| Siokas, V | 1 |
| Rattay, TW | 1 |
| Häberle, HA | 1 |
| Riessen, R | 1 |
| Brendel, B | 1 |
| Haug, I | 1 |
| Bösel, R | 1 |
| Zago, M | 1 |
| Martus, P | 1 |
| Ziemann, U | 1 |
| Mengel, A | 1 |
| Feil, K | 1 |
| Cossu, G | 1 |
| Sterkel, S | 1 |
| Akinyemi, A | 1 |
| Sanchez-Gonzalez, MA | 1 |
| Michel, G | 1 |
| Reynolds, JC | 1 |
| Rittenberger, JC | 1 |
| Callaway, CW | 1 |
| Sugaya, N | 1 |
| Willoughby, RE | 1 |
| Tieves, KS | 1 |
| Hoffman, GM | 1 |
| Ghanayem, NS | 1 |
| Amlie-Lefond, CM | 1 |
| Schwabe, MJ | 1 |
| Chusid, MJ | 1 |
| Rupprecht, CE | 1 |
| Jackson, AC | 1 |
| Miltner, FO | 2 |
| Macchio, GJ | 1 |
| Ito, V | 1 |
| Sahgal, V | 1 |
| Zafonte, RD | 1 |
| Watanabe, T | 1 |
| Mann, NR | 1 |
| Horiguchi, J | 1 |
| Inami, Y | 1 |
| Shoda, T | 1 |
| Castaigne, P | 1 |
| Laplane, D | 1 |
| Autret, A | 1 |
| Wallnöfer, H | 1 |
| Schiller, L | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Utility of Amantadine Hydrochloride in the Treatment of Post-traumatic Irritability: A Randomized, Double-Blind, Placebo-Controlled Trial[NCT00627250] | 76 participants (Actual) | Interventional | 2003-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
2 reviews available for amantadine and Coma
| Article | Year |
|---|---|
Therapeutic options to enhance coma arousal after traumatic brain injury: state of the art of current treatments to improve coma recovery.
Topics: Amantadine; Arousal; Brain Injuries; Cell Transplantation; Central Nervous System Stimulants; Coma; | 2014 |
Influenza-associated encephalopathy in Japan.
Topics: Amantadine; Antiviral Agents; Brain Diseases; Child; Coma; Fever; Humans; Incidence; Influenza A vir | 2002 |
Trials
2 trials available for amantadine and Coma
| Article | Year |
|---|---|
Amantadine for NeuroenhaNcement in acutE patients Study - a protocol for a prospective pilot proof of concept phase IIb study in intensive and intermediate care unit patients (ANNES).
Topics: Adult; Amantadine; Brain Injuries; Brain Injuries, Traumatic; Clinical Trials, Phase II as Topic; Co | 2023 |
[Clinical study of the psychostimulant action of amantadine].
Topics: Amantadine; Antidepressive Agents; Attention; Central Nervous System; Clinical Trials as Topic; Coma | 1974 |
Other Studies
10 other studies available for amantadine and Coma
| Article | Year |
|---|---|
Preserving brain function in a comatose patient with septic hyperpyrexia (41.6 °C): a case report.
Topics: Adult; Amantadine; Anticonvulsants; Brain; Brain Injuries; Cognition Disorders; Coma; Dopamine Agent | 2017 |
Methylphenidate and amantadine to stimulate reawakening in comatose patients resuscitated from cardiac arrest.
Topics: Adult; Aged; Amantadine; Cardiopulmonary Resuscitation; Central Nervous System Stimulants; Cohort St | 2013 |
Survival after treatment of rabies with induction of coma.
Topics: Adolescent; Amantadine; Anesthetics; Animals; Antiviral Agents; Athetosis; Benzodiazepines; Bites an | 2005 |
Recovery from rabies.
Topics: Amantadine; Anesthetics; Animals; Antiviral Agents; Bites and Stings; Chiroptera; Coma; Excitatory A | 2005 |
[Valve of symptomatic therapy with memantine in cerebral coma. I. Correlation with coma stages and EEG spectral patterns].
Topics: Adolescent; Adult; Amantadine; Coma; Electroencephalography; Female; Humans; Male; Memantine | 1982 |
[Valve of symptomatic therapy with memantine in cerebral coma. II. Development of stretch synergisms in coma with brain stem symptoms].
Topics: Amantadine; Brain Stem; Coma; Electromyography; Female; Humans; Male; Memantine; Movement; Posture | 1982 |
Amantadine-induced coma.
Topics: Adult; Amantadine; Coma; Humans; Kidney Failure, Chronic; Male; Multiple Sclerosis | 1993 |
Amantadine: a potential treatment for the minimally conscious state.
Topics: Adult; Amantadine; Brain Injuries; Coma; Consciousness; Dopamine Agents; Dose-Response Relationship, | 1998 |
Effects of long-term amantadine treatment on clinical symptoms and EEG of a patient in a vegetative state.
Topics: Amantadine; Brain; Coma; Electroencephalography; Female; Humans; Levodopa; Middle Aged; Tomography, | 1990 |
[Aminoadamantane therapy in comatose conditions].
Topics: Adult; Aged; Amantadine; Coma; Epilepsy; Female; Hepatic Encephalopathy; Humans; Male; Middle Aged | 1974 |