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amantadine and Coma

amantadine has been researched along with Coma in 14 studies

amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source

Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Research Excerpts

ExcerptRelevanceReference
" Methylphenidate and amantadine have treated coma in traumatically-brain-injured patients with mixed success, but have not been explored in post-arrest patients."7.79Methylphenidate and amantadine to stimulate reawakening in comatose patients resuscitated from cardiac arrest. ( Callaway, CW; Reynolds, JC; Rittenberger, JC, 2013)
"1,3-Dimethyl-5-aminoadamantane (DMAA, D-145, memantine, Memantine) was used in a group of 25 patients of both sexes in coma and with brain stem symptoms for symptomatic therapy."7.66[Valve of symptomatic therapy with memantine in cerebral coma. II. Development of stretch synergisms in coma with brain stem symptoms]. ( Miltner, FO, 1982)
"The results of our study will help to systematically assess the clinical utility of amantadine for treatment of persisting coma in non-traumatic brain injury."5.69Amantadine for NeuroenhaNcement in acutE patients Study - a protocol for a prospective pilot proof of concept phase IIb study in intensive and intermediate care unit patients (ANNES). ( Adeyemi, K; Blum, C; Bösel, R; Brendel, B; Feil, K; Häberle, HA; Haug, I; Hofmann, A; Martus, P; Mengel, A; Rattay, TW; Riessen, R; Schwarz, P; Single, C; Siokas, V; Zago, M; Ziemann, U, 2023)
"Amantadine toxicity is a particular problem in patients with renal insufficiency because 90% of an oral dose is excreted unchanged in the urine."5.29Amantadine-induced coma. ( Ito, V; Macchio, GJ; Sahgal, V, 1993)
"The significant improvement of coma stages 2 and 3 already during the treatment with memantine should be emphasized."5.26[Valve of symptomatic therapy with memantine in cerebral coma. I. Correlation with coma stages and EEG spectral patterns]. ( Miltner, FO, 1982)
"We propose that a combination of levetiracetam and amantadine may provide neuroprotective and neurorestorative properties when administered during a period of hyperpyrexia accompanied by any form of mental status changes, particularly if there is a decline in Glasgow Coma Score."3.85Preserving brain function in a comatose patient with septic hyperpyrexia (41.6 °C): a case report. ( Akinyemi, A; Michel, G; Sanchez-Gonzalez, MA; Sterkel, S, 2017)
" Methylphenidate and amantadine have treated coma in traumatically-brain-injured patients with mixed success, but have not been explored in post-arrest patients."3.79Methylphenidate and amantadine to stimulate reawakening in comatose patients resuscitated from cardiac arrest. ( Callaway, CW; Reynolds, JC; Rittenberger, JC, 2013)
"1,3-Dimethyl-5-aminoadamantane (DMAA, D-145, memantine, Memantine) was used in a group of 25 patients of both sexes in coma and with brain stem symptoms for symptomatic therapy."3.66[Valve of symptomatic therapy with memantine in cerebral coma. II. Development of stretch synergisms in coma with brain stem symptoms]. ( Miltner, FO, 1982)
"Optimizing the recovery from coma is a priority in seeking to improve patients' functional outcomes."2.50Therapeutic options to enhance coma arousal after traumatic brain injury: state of the art of current treatments to improve coma recovery. ( Cossu, G, 2014)
"Influenza encephalopathy typically is associated with a sudden onset of high fever, severe convulsions, rapidly progressive coma, and death within 2 or 3 days."2.41Influenza-associated encephalopathy in Japan. ( Sugaya, N, 2002)
"Treatment included induction of coma while a native immune response matured; rabies vaccine was not administered."1.33Survival after treatment of rabies with induction of coma. ( Amlie-Lefond, CM; Chusid, MJ; Ghanayem, NS; Hoffman, GM; Rupprecht, CE; Schwabe, MJ; Tieves, KS; Willoughby, RE, 2005)
"Amantadine toxicity is a particular problem in patients with renal insufficiency because 90% of an oral dose is excreted unchanged in the urine."1.29Amantadine-induced coma. ( Ito, V; Macchio, GJ; Sahgal, V, 1993)
"The significant improvement of coma stages 2 and 3 already during the treatment with memantine should be emphasized."1.26[Valve of symptomatic therapy with memantine in cerebral coma. I. Correlation with coma stages and EEG spectral patterns]. ( Miltner, FO, 1982)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19904 (28.57)18.7374
1990's3 (21.43)18.2507
2000's3 (21.43)29.6817
2010's3 (21.43)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Hofmann, A1
Blum, C1
Single, C1
Adeyemi, K1
Schwarz, P1
Siokas, V1
Rattay, TW1
Häberle, HA1
Riessen, R1
Brendel, B1
Haug, I1
Bösel, R1
Zago, M1
Martus, P1
Ziemann, U1
Mengel, A1
Feil, K1
Cossu, G1
Sterkel, S1
Akinyemi, A1
Sanchez-Gonzalez, MA1
Michel, G1
Reynolds, JC1
Rittenberger, JC1
Callaway, CW1
Sugaya, N1
Willoughby, RE1
Tieves, KS1
Hoffman, GM1
Ghanayem, NS1
Amlie-Lefond, CM1
Schwabe, MJ1
Chusid, MJ1
Rupprecht, CE1
Jackson, AC1
Miltner, FO2
Macchio, GJ1
Ito, V1
Sahgal, V1
Zafonte, RD1
Watanabe, T1
Mann, NR1
Horiguchi, J1
Inami, Y1
Shoda, T1
Castaigne, P1
Laplane, D1
Autret, A1
Wallnöfer, H1
Schiller, L1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Utility of Amantadine Hydrochloride in the Treatment of Post-traumatic Irritability: A Randomized, Double-Blind, Placebo-Controlled Trial[NCT00627250]76 participants (Actual)Interventional2003-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for amantadine and Coma

ArticleYear
Therapeutic options to enhance coma arousal after traumatic brain injury: state of the art of current treatments to improve coma recovery.
    British journal of neurosurgery, 2014, Volume: 28, Issue:2

    Topics: Amantadine; Arousal; Brain Injuries; Cell Transplantation; Central Nervous System Stimulants; Coma;

2014
Influenza-associated encephalopathy in Japan.
    Seminars in pediatric infectious diseases, 2002, Volume: 13, Issue:2

    Topics: Amantadine; Antiviral Agents; Brain Diseases; Child; Coma; Fever; Humans; Incidence; Influenza A vir

2002

Trials

2 trials available for amantadine and Coma

ArticleYear
Amantadine for NeuroenhaNcement in acutE patients Study - a protocol for a prospective pilot proof of concept phase IIb study in intensive and intermediate care unit patients (ANNES).
    BMC neurology, 2023, Aug-22, Volume: 23, Issue:1

    Topics: Adult; Amantadine; Brain Injuries; Brain Injuries, Traumatic; Clinical Trials, Phase II as Topic; Co

2023
[Clinical study of the psychostimulant action of amantadine].
    La Nouvelle presse medicale, 1974, Jun-29, Volume: 3, Issue:26

    Topics: Amantadine; Antidepressive Agents; Attention; Central Nervous System; Clinical Trials as Topic; Coma

1974

Other Studies

10 other studies available for amantadine and Coma

ArticleYear
Preserving brain function in a comatose patient with septic hyperpyrexia (41.6 °C): a case report.
    Journal of medical case reports, 2017, Feb-13, Volume: 11, Issue:1

    Topics: Adult; Amantadine; Anticonvulsants; Brain; Brain Injuries; Cognition Disorders; Coma; Dopamine Agent

2017
Methylphenidate and amantadine to stimulate reawakening in comatose patients resuscitated from cardiac arrest.
    Resuscitation, 2013, Volume: 84, Issue:6

    Topics: Adult; Aged; Amantadine; Cardiopulmonary Resuscitation; Central Nervous System Stimulants; Cohort St

2013
Survival after treatment of rabies with induction of coma.
    The New England journal of medicine, 2005, Jun-16, Volume: 352, Issue:24

    Topics: Adolescent; Amantadine; Anesthetics; Animals; Antiviral Agents; Athetosis; Benzodiazepines; Bites an

2005
Recovery from rabies.
    The New England journal of medicine, 2005, Jun-16, Volume: 352, Issue:24

    Topics: Amantadine; Anesthetics; Animals; Antiviral Agents; Bites and Stings; Chiroptera; Coma; Excitatory A

2005
[Valve of symptomatic therapy with memantine in cerebral coma. I. Correlation with coma stages and EEG spectral patterns].
    Arzneimittel-Forschung, 1982, Volume: 32, Issue:10

    Topics: Adolescent; Adult; Amantadine; Coma; Electroencephalography; Female; Humans; Male; Memantine

1982
[Valve of symptomatic therapy with memantine in cerebral coma. II. Development of stretch synergisms in coma with brain stem symptoms].
    Arzneimittel-Forschung, 1982, Volume: 32, Issue:10

    Topics: Amantadine; Brain Stem; Coma; Electromyography; Female; Humans; Male; Memantine; Movement; Posture

1982
Amantadine-induced coma.
    Archives of physical medicine and rehabilitation, 1993, Volume: 74, Issue:10

    Topics: Adult; Amantadine; Coma; Humans; Kidney Failure, Chronic; Male; Multiple Sclerosis

1993
Amantadine: a potential treatment for the minimally conscious state.
    Brain injury, 1998, Volume: 12, Issue:7

    Topics: Adult; Amantadine; Brain Injuries; Coma; Consciousness; Dopamine Agents; Dose-Response Relationship,

1998
Effects of long-term amantadine treatment on clinical symptoms and EEG of a patient in a vegetative state.
    Clinical neuropharmacology, 1990, Volume: 13, Issue:1

    Topics: Amantadine; Brain; Coma; Electroencephalography; Female; Humans; Levodopa; Middle Aged; Tomography,

1990
[Aminoadamantane therapy in comatose conditions].
    Die Medizinische Welt, 1974, Apr-19, Volume: 25, Issue:16

    Topics: Adult; Aged; Amantadine; Coma; Epilepsy; Female; Hepatic Encephalopathy; Humans; Male; Middle Aged

1974