Page last updated: 2024-10-22

amantadine and Chorea

amantadine has been researched along with Chorea in 21 studies

amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source

Chorea: Involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movement. Hypotonia and pendular reflexes are often associated. Conditions which feature recurrent or persistent episodes of chorea as a primary manifestation of disease are referred to as CHOREATIC DISORDERS. Chorea is also a frequent manifestation of BASAL GANGLIA DISEASES.

Research Excerpts

ExcerptRelevanceReference
"Huntington chorea, like levodopa-induced dyskinesias, may be responsive to amantadine hydrochloride treatment."9.10A randomized trial of amantadine in Huntington disease. ( Dewey, RB; O'Suilleabhain, P, 2003)
"We report an 80-year-old woman with hemichorea probably due to amantadine hydrochloride."7.69[A case of multiple cerebral infarctions associated with hemichorea induced by amantadine hydrochloride]. ( Morimatsu, M; Negoro, K; Tsuda, N, 1994)
"Paraneoplastic chorea is typically a subacute progressive hyperkinetic movement disorder."5.51Anti-CV2/CRMP5 Paraneoplastic Chorea Effectively Managed with Intravenous Amantadine. ( Ahn, JH; Cho, JW; Ha, J; Kim, JS; Kim, JW; Kim, M; Lee, JH; Na, BS; Youn, J, 2019)
"Chorea scores were lower with amantadine (usually 400 mg/d) than placebo, with a median reduction in extremity chorea at rest of 36% (p = 0."5.10Huntington's disease: a randomized, controlled trial using the NMDA-antagonist amantadine. ( Chase, TN; Farmer, C; Gillespie, M; Morris, MJ; Mosby, K; Verhagen Metman, L; Wuu, J, 2002)
"Huntington chorea, like levodopa-induced dyskinesias, may be responsive to amantadine hydrochloride treatment."5.10A randomized trial of amantadine in Huntington disease. ( Dewey, RB; O'Suilleabhain, P, 2003)
"If HD chorea requires treatment, clinicians should prescribe tetrabenazine (up to 100 mg/day), amantadine (300-400 mg/day), or riluzole (200 mg/day) (Level B) for varying degrees of expected benefit."3.78Evidence-based guideline: pharmacologic treatment of chorea in Huntington disease: report of the guideline development subcommittee of the American Academy of Neurology. ( Armstrong, MJ; Miyasaki, JM, 2012)
"We report an 80-year-old woman with hemichorea probably due to amantadine hydrochloride."3.69[A case of multiple cerebral infarctions associated with hemichorea induced by amantadine hydrochloride]. ( Morimatsu, M; Negoro, K; Tsuda, N, 1994)
"We have studied the urinary excretion of 1,4-methylhistamine (1,4-MeHm), 5-hydroxyindole-3-acetic acid (5-HIAA) and homovanillic acid (HVA) in patients with Parkinson's disease, choreiform movements and essential tremor."3.65Urinary monoamine metabolite excretion in disorders of movement. Effects of amantadine and levodopa. ( Fleming, AM; Lenman, JA; Reid, A; Turnbull, MJ, 1977)
"Cranial CT revealed a chronic subdural hematoma (CSDH) that covered the left parietal lobe."2.58[Chorea due to chronic subdural hematoma]. ( Kanemaru, K; Murayama, S; Sengoku, R; Shibukawa, M; Shiraishi, T; Takanashi, S, 2018)
"Paraneoplastic chorea is typically a subacute progressive hyperkinetic movement disorder."1.51Anti-CV2/CRMP5 Paraneoplastic Chorea Effectively Managed with Intravenous Amantadine. ( Ahn, JH; Cho, JW; Ha, J; Kim, JS; Kim, JW; Kim, M; Lee, JH; Na, BS; Youn, J, 2019)
"Treatment included induction of coma while a native immune response matured; rabies vaccine was not administered."1.33Survival after treatment of rabies with induction of coma. ( Amlie-Lefond, CM; Chusid, MJ; Ghanayem, NS; Hoffman, GM; Rupprecht, CE; Schwabe, MJ; Tieves, KS; Willoughby, RE, 2005)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19909 (42.86)18.7374
1990's1 (4.76)18.2507
2000's5 (23.81)29.6817
2010's6 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ha, J2
Na, BS2
Ahn, JH2
Kim, M2
Kim, JW2
Lee, JH2
Cho, JW2
Kim, JS2
Youn, J2
Doher, N1
Gupta, HV1
Shiraishi, T1
Sengoku, R1
Takanashi, S1
Shibukawa, M1
Kanemaru, K1
Murayama, S1
Park, H1
Jeon, BS1
Shin, JH1
Park, SH1
Armstrong, MJ1
Miyasaki, JM1
Verhagen Metman, L1
Morris, MJ1
Farmer, C1
Gillespie, M1
Mosby, K1
Wuu, J1
Chase, TN1
O'Suilleabhain, P1
Dewey, RB1
Furukawa, Y1
Filiano, JJ1
Kish, SJ1
Willoughby, RE1
Tieves, KS1
Hoffman, GM1
Ghanayem, NS1
Amlie-Lefond, CM1
Schwabe, MJ1
Chusid, MJ1
Rupprecht, CE1
Bonelli, RM1
Hofmann, P1
Tsuda, N1
Negoro, K1
Morimatsu, M1
Gray, MW1
Herzberg, L1
Lerman, JA1
Turnbull, MJ2
Victoratos, G1
Agnoli, A1
Ruggieri, S1
Casacchia, M1
Lenman, JA1
Reid, A1
Fleming, AM1
Mundinger, F1
Milios, E1
Godwin-Austen, RB1
Frears, CC1
Bergmann, S1
Parkes, JD1
Knill-Jones, RP1
Schergna, E1
Ferro-Milone, F1
Parisen-Toldin, P1
Borromei, A1
Lorizio, A1
Ecari, U1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Amantadine for the Treatment of Behavioral Disturbance in Frontotemporal Dementia (FTD)[NCT00127114]Phase 40 participants (Actual)Interventional2005-09-30Withdrawn (stopped due to No funding and exclusion criteria were to stringent.)
Combining a Dopamine Agonist and Selective Serotonin Reuptake Inhibitor for Treatment of Depression: A Double-Blind, Randomized Study[NCT00086307]Phase 239 participants (Actual)Interventional2004-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Montgomery Asberg Depression Rating Scale (MADRS)

The Montgomery Asberg Depression Rating Scale (MADRS) is a 10 item scale for assessing the severity of depression. Items are rated on a scale of 0 to 6, so the maximum score is 60 and the minimum is 0, where 60 is the most severe depression. Scores of 18 or greater are generally considered to indicate a moderate level of depression. (NCT00086307)
Timeframe: Weekly

InterventionScore on a scale (Least Squares Mean)
Pramipexole22.629
Escitalopram26.102
Escitalopram and Pramipexole29.455

Reviews

2 reviews available for amantadine and Chorea

ArticleYear
[Chorea due to chronic subdural hematoma].
    Rinsho shinkeigaku = Clinical neurology, 2018, Jun-27, Volume: 58, Issue:6

    Topics: Aged, 80 and over; Amantadine; Chorea; Female; Hematoma, Subdural, Chronic; Humans; Magnetic Resonan

2018
A systematic review of the treatment studies in Huntington's disease since 1990.
    Expert opinion on pharmacotherapy, 2007, Volume: 8, Issue:2

    Topics: Amantadine; Antipsychotic Agents; Chorea; Depression; Humans; Huntington Disease; Neuroprotective Ag

2007

Trials

4 trials available for amantadine and Chorea

ArticleYear
Huntington's disease: a randomized, controlled trial using the NMDA-antagonist amantadine.
    Neurology, 2002, Sep-10, Volume: 59, Issue:5

    Topics: Adult; Aged; Amantadine; Chorea; Cognition; Cross-Over Studies; Dopamine Agents; Double-Blind Method

2002
A randomized trial of amantadine in Huntington disease.
    Archives of neurology, 2003, Volume: 60, Issue:7

    Topics: Amantadine; Chorea; Cross-Over Studies; Elbow; Female; Humans; Huntington Disease; Male; Mental Proc

2003
Restatement and prospectives of ergot alkaloids in clinical neurology and psychiatry.
    Pharmacology, 1978, Volume: 16 Suppl 1

    Topics: Aged; Amantadine; Basal Ganglia Diseases; Bromocriptine; Chorea; Clinical Trials as Topic; Depressio

1978
Combined treatment of parkinsonism with L-dopa and amantadine.
    Lancet (London, England), 1970, Aug-22, Volume: 2, Issue:7669

    Topics: Aged; Amantadine; Chorea; Clinical Trials as Topic; Dihydroxyphenylalanine; Female; Humans; Hypotens

1970

Other Studies

15 other studies available for amantadine and Chorea

ArticleYear
Anti-CV2/CRMP5 Paraneoplastic Chorea Effectively Managed with Intravenous Amantadine.
    Tremor and other hyperkinetic movements (New York, N.Y.), 2019, Volume: 9

    Topics: Administration, Intravenous; Amantadine; Autoantibodies; Carrier Proteins; Chorea; Dopamine Agents;

2019
Paraneoplastic Chorea Managed with Intravenous Amantadine.
    Tremor and other hyperkinetic movements (New York, N.Y.), 2019, Volume: 9

    Topics: Amantadine; Chorea; Humans; Huntington Disease

2019
Author Response to Letter to the Editor.
    Tremor and other hyperkinetic movements (New York, N.Y.), 2019, Volume: 9

    Topics: Amantadine; Chorea; Humans

2019
A patient with 41 CAG repeats in SCA17 presenting with parkinsonism and chorea.
    Parkinsonism & related disorders, 2016, Volume: 22

    Topics: Amantadine; Antiparkinson Agents; Benzothiazoles; Brain; Chorea; Humans; Levodopa; Male; Middle Aged

2016
Evidence-based guideline: pharmacologic treatment of chorea in Huntington disease: report of the guideline development subcommittee of the American Academy of Neurology.
    Neurology, 2012, Aug-07, Volume: 79, Issue:6

    Topics: Adult; Amantadine; Anticonvulsants; Chorea; Evidence-Based Medicine; Humans; Huntington Disease; Ril

2012
Amantadine for levodopa-induced choreic dyskinesia in compound heterozygotes for GCH1 mutations.
    Movement disorders : official journal of the Movement Disorder Society, 2004, Volume: 19, Issue:10

    Topics: Amantadine; Antiparkinson Agents; Child; Chorea; Dopamine Agents; Dyskinesia, Drug-Induced; GTP Cycl

2004
Survival after treatment of rabies with induction of coma.
    The New England journal of medicine, 2005, Jun-16, Volume: 352, Issue:24

    Topics: Adolescent; Amantadine; Anesthetics; Animals; Antiviral Agents; Athetosis; Benzodiazepines; Bites an

2005
[A case of multiple cerebral infarctions associated with hemichorea induced by amantadine hydrochloride].
    Rinsho shinkeigaku = Clinical neurology, 1994, Volume: 34, Issue:4

    Topics: Aged; Aged, 80 and over; Amantadine; Cerebral Infarction; Chorea; Female; Humans; Tomography, Emissi

1994
Letter: Amantadine in chorea.
    Lancet (London, England), 1975, Jul-19, Volume: 2, Issue:7925

    Topics: Aged; Amantadine; Chorea; Drug Evaluation; Homovanillic Acid; Humans; Huntington Disease; Hydroxyind

1975
Urinary monoamine metabolite excretion in disorders of movement. Effects of amantadine and levodopa.
    Journal of the neurological sciences, 1977, Volume: 32, Issue:2

    Topics: Amantadine; Chorea; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; Methylhistamines;

1977
[Experiences with memantine in the treatment of severe spastic and extrapyramidal movement disorders in combination with stereotaxic surgery].
    Der Nervenarzt, 1985, Volume: 56, Issue:2

    Topics: Adolescent; Adult; Aged; Amantadine; Athetosis; Basal Ganglia Diseases; Cerebral Palsy; Child; Chore

1985
[Recent therapeutic conquests in extrapyramidal syndromes].
    Minerva medica, 1970, Dec-19, Volume: 61, Issue:101

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Amantadine; Athetosis; Brain Diseases; Central

1970
[Changes in the electroencephalogram during treatment with amantadine].
    Minerva medica, 1971, Oct-31, Volume: 62, Issue:82

    Topics: Amantadine; Brain; Chorea; Electroencephalography; Extrapyramidal Tracts; Humans; Movement Disorders

1971
[On the therapeutic use of amantadine hydrochloride in non-parkinsonian hyperkinetic syndromes].
    Minerva medica, 1971, Oct-31, Volume: 62, Issue:82

    Topics: Adult; Amantadine; Athetosis; Brain Diseases; Brain Injuries; Cerebrovascular Disorders; Child; Chor

1971
[Clinical and electroencephalographic observations on the action of amantadine in the dystonic-athetosic disorders of infentile cerebral paralysis].
    Minerva medica, 1971, Oct-31, Volume: 62, Issue:82

    Topics: Adolescent; Amantadine; Athetosis; Brain; Cerebral Palsy; Child; Child, Preschool; Chorea; Electroen

1971