Page last updated: 2024-10-22

amantadine and Avian Flu

amantadine has been researched along with Avian Flu in 36 studies

amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source

Research Excerpts

ExcerptRelevanceReference
"Vaccines have been used in avian influenza (AI) control programs to prevent, manage or eradicate AI from poultry and other birds."2.45Avian influenza vaccines and therapies for poultry. ( Swayne, DE, 2009)
"In the advent of an influenza virus pandemic it is likely that the administration of antiviral drugs will be an important first line of defence against the virus."2.44Antiviral drugs for the control of pandemic influenza virus. ( Sugrue, RJ; Sutejo, R; Tan, BH; Yeo, DS, 2008)
"The widespread epidemic of avian influenza in domestic birds increases the likelihood for mutational events and genetic reassortment."2.42Avian influenza: a new pandemic threat? ( Baddour, LM; Prabhu, RM; Smith, TF; Trampuz, A, 2004)
"However, several highly pathogenic avian influenza viruses show amantadine-resistance mutations in the viral matrix 2 (M2) protein."1.72Abuse of amantadine in poultry may be associated with higher fatality rate of H5N1 infections in humans. ( Fu, YF; Hu, J; Jiang, SC; Li, ZL; Yuan, S; Zhang, ZW; Zhu, F, 2022)
"Antiviral susceptibility screening of avian influenza (AI) H9N2 viruses is crucial considering their role at the animal-human interface and potential to cause human infections."1.51Amantadine resistance markers among low pathogenic avian influenza H9N2 viruses isolated from poultry in India, during 2009-2017. ( Keng, SS; Kode, SS; Mullick, J; Pawar, SD; Tare, DS, 2019)
" Two groups received either 20 or 40 µl/kg body weight/day Zataria multiflora essential oils (ZM) seven days before the challenge while two other groups received the essential oil at the same dosage but after H9N2 challenge."1.48Zataria multiflora essential oil reduces replication rate of avian influenza virus (H9N2 subtype) in challenged broiler chicks. ( Barin, A; Ghalyanchilangeroudi, A; Karimi, V; Shayeganmehr, A; Vasfi Marandi, M, 2018)
"Highly pathogenic avian influenza (HPAI) H5N1 virus continues to undergo substantial evolution."1.43Re-emergence of amantadine-resistant variants among highly pathogenic avian influenza H5N1 viruses in Egypt. ( Ali, MA; Bagato, O; El-Shesheny, R; Hassanneen, HM; Kandeil, A; Kayali, G; Mahmoud, SH; Mostafa, A; Webby, RJ, 2016)
"Low pathogenic avian influenza virus of subtype H9N2 is panzootic in multiple avian species causing respiratory manifestations and severe economic losses."1.42Isolation and full genome characterization of avian influenza subtype H9N2 from poultry respiratory disease outbreak in Egypt. ( Abd Elrazek, A; Halami, MY; Heenemann, K; Ibrahim, M; Parvin, R; Shehata, AA; Sultan, H; Talaat, S; Vahlenkamp, T, 2015)
"Highly pathogenic H5N1 avian influenza viruses have spread in poultry and wild birds in Asia, Europe, and Africa since 2003."1.40Characterization of the amantadine-resistant H5N1 highly pathogenic avian influenza variants isolated from quails in Southern China. ( Dong, G; He, H; Ji, G; Luo, J; Peng, C; Wu, B; Zhou, K, 2014)
"Our results showed that most of avian influenza viruses were amantadine resistant, Mutations V27I and S31N were founded in these isolates."1.36[Detection of molecular markers of amantadine resistance in avian influenza viruses by pyrosequencing]. ( Li, JM; Liu, HL; Lv, Y; Sun, CY; Wang, ZL; Zhang, W; Zhao, YL; Zheng, DX, 2010)
"Resistance of influenza viruses to antiviral drugs can emerge following medication or may result from natural variation."1.35Detection of molecular markers of antiviral resistance in influenza A (H5N1) viruses using a pyrosequencing method. ( Balish, A; Bright, RA; Deyde, VM; Gubareva, LV; Klimov, AI; Lindstrom, S; Nguyen, T; Shu, B, 2009)
"Matrix (M) protein genes of 17 H9N2 avian influenza viruses (AIVs) isolated from chickens in northern China during the last 10 years were completely sequenced and phylogenetically analyzed."1.35Evolution analysis of the matrix (M) protein genes of 17 H9N2 chicken influenza viruses isolated in northern China during 1998-2008. ( Cao, S; Hu, B; Huang, Y; Khan, MI; Wen, X; Xu, D; Zhang, X, 2009)
"Since 2003, highly pathogenic A(H5N1) influenza viruses have been the cause of large-scale death in poultry and the subsequent infection and death of over 140 humans."1.34Susceptibility of highly pathogenic A(H5N1) avian influenza viruses to the neuraminidase inhibitors and adamantanes. ( Barr, IG; Brown, L; Hurt, AC; Komadina, N; Selleck, P; Shaw, R, 2007)
"These six influenza isolates were obtained from four different provinces of Thailand during the avian influenza outbreak in Asia from late 2003 to May 2004."1.33Molecular characterization of the complete genome of human influenza H5N1 virus isolates from Thailand. ( Auewarakul, P; Boonnak, K; Charoenying, PC; Khanyok, R; Kijphati, R; Pooruk, P; Puthavathana, P; Sangsiriwut, K; Sawanpanyalert, P; Thawachsupa, P, 2005)
"To analyze the compatibility of avian influenza A virus hemagglutinins (HAs) and human influenza A virus matrix (M) proteins M1 and M2, we doubly infected Madin-Darby canine kidney cells with amantadine (1-aminoadamantane hydrochloride)-resistant human viruses and amantadine-sensitive avian strains."1.31Cooperation between the hemagglutinin of avian viruses and the matrix protein of human influenza A viruses. ( Krauss, S; Scholtissek, C; Stech, J; Webster, RG, 2002)
"Amantadine has been accepted for both the treatment and prophylaxis of influenza A virus infections."1.28Biologic potential of amantadine-resistant influenza A virus in an avian model. ( Bean, WJ; Threlkeld, SC; Webster, RG, 1989)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19902 (5.56)18.7374
1990's0 (0.00)18.2507
2000's21 (58.33)29.6817
2010's12 (33.33)24.3611
2020's1 (2.78)2.80

Authors

AuthorsStudies
Yuan, S1
Jiang, SC1
Zhang, ZW1
Fu, YF1
Zhu, F1
Li, ZL1
Hu, J1
Kode, SS1
Pawar, SD1
Tare, DS1
Keng, SS1
Mullick, J1
Shayeganmehr, A1
Vasfi Marandi, M1
Karimi, V1
Barin, A1
Ghalyanchilangeroudi, A1
Xie, S1
Wen, K1
Xie, J1
Zheng, Y1
Peng, T1
Wang, J1
Yao, K1
Ding, S1
Jiang, H1
Dong, G1
Luo, J1
Zhou, K1
Wu, B1
Peng, C1
Ji, G1
He, H1
Tosh, C2
Nagarajan, S2
Murugkar, HV2
Kumar, M1
Pandey, M1
Jolhe, DK1
Tripathi, S2
Shukla, S1
Ved, N1
Mishra, A1
Ghosh, RC1
Kulkarni, DD2
Shehata, AA1
Parvin, R1
Sultan, H1
Halami, MY1
Talaat, S1
Abd Elrazek, A1
Ibrahim, M1
Heenemann, K1
Vahlenkamp, T1
Naguib, MM1
Hagag, N1
El-Sanousi, AA1
Hussein, HA1
Arafa, AS1
El-Shesheny, R1
Bagato, O1
Kandeil, A1
Mostafa, A1
Mahmoud, SH1
Hassanneen, HM1
Webby, RJ1
Ali, MA1
Kayali, G1
Abdelwhab, EM1
Veits, J1
Mettenleiter, TC1
Sugrue, RJ1
Tan, BH1
Yeo, DS1
Sutejo, R1
Lee, J1
Song, YJ1
Park, JH1
Lee, JH1
Baek, YH1
Song, MS1
Oh, TK1
Han, HS1
Pascua, PN1
Choi, YK1
Deyde, VM1
Nguyen, T1
Bright, RA1
Balish, A1
Shu, B1
Lindstrom, S1
Klimov, AI1
Gubareva, LV1
Huang, Y1
Hu, B1
Wen, X1
Cao, S1
Xu, D1
Zhang, X1
Khan, MI1
Kwon, YK1
Kwon, KY1
Joh, SJ1
Kim, MC1
Kang, MS1
Lee, YJ1
Kwon, JH1
Kim, JH1
Katare, M1
Jain, R1
Khandia, R1
Syed, Z1
Behera, P1
Patil, S1
Dubey, SC1
Liu, HL1
Lv, Y1
Zheng, DX1
Zhao, YL1
Sun, CY1
Zhang, W1
Li, JM1
Wang, ZL1
Trampuz, A1
Prabhu, RM1
Smith, TF1
Baddour, LM1
Suzuki, H1
Puthavathana, P1
Auewarakul, P1
Charoenying, PC1
Sangsiriwut, K1
Pooruk, P1
Boonnak, K1
Khanyok, R1
Thawachsupa, P1
Kijphati, R1
Sawanpanyalert, P1
Normile, D1
Enserink, M1
Sauerbrei, A1
Haertl, A1
Brandstaedt, A1
Schmidtke, M1
Wutzler, P1
Ilyushina, NA1
Govorkova, EA1
Webster, RG6
Cheung, CL1
Rayner, JM1
Smith, GJ1
Wang, P1
Naipospos, TS1
Zhang, J1
Yuen, KY1
Peiris, JS1
Guan, Y1
Chen, H1
Luo, RP1
Zhu, YM1
Xu, ZY1
Gao, JP1
Yu, SJ1
Hurt, AC1
Selleck, P1
Komadina, N1
Shaw, R1
Brown, L1
Barr, IG1
Aamir, UB1
Wernery, U1
Ilyushina, N1
Chutinimitkul, S1
Songserm, T1
Amonsin, A1
Payungporn, S1
Suwannakarn, K1
Damrongwatanapokin, S1
Chaisingh, A1
Nuansrichay, B1
Chieochansin, T1
Theamboonlers, A1
Poovorawan, Y1
He, G1
Qiao, J1
Dong, C1
He, C1
Zhao, L1
Tian, Y1
Swayne, DE1
Scholtissek, C1
Stech, J1
Krauss, S1
Bean, WJ2
Threlkeld, SC1
Kawaoka, Y1
Beard, CW1
Brugh, M1

Reviews

4 reviews available for amantadine and Avian Flu

ArticleYear
Antiviral drugs for the control of pandemic influenza virus.
    Annals of the Academy of Medicine, Singapore, 2008, Volume: 37, Issue:6

    Topics: Amantadine; Animals; Antiviral Agents; Birds; Disease Outbreaks; Global Health; Humans; Influenza A

2008
Avian influenza: a new pandemic threat?
    Mayo Clinic proceedings, 2004, Volume: 79, Issue:4

    Topics: Amantadine; Animals; Antiviral Agents; Asia; Communicable Diseases, Emerging; Disease Outbreaks; Dru

2004
[Super pathogenic avian influenza].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2004, Nov-10, Volume: 93, Issue:11

    Topics: Acetamides; Amantadine; Animals; Antiviral Agents; Chickens; Disease Outbreaks; Guanidines; Humans;

2004
Avian influenza vaccines and therapies for poultry.
    Comparative immunology, microbiology and infectious diseases, 2009, Volume: 32, Issue:4

    Topics: Amantadine; Animals; Antiviral Agents; Birds; Cloning, Molecular; Genetic Vectors; Hemagglutinin Gly

2009

Other Studies

32 other studies available for amantadine and Avian Flu

ArticleYear
Abuse of amantadine in poultry may be associated with higher fatality rate of H5N1 infections in humans.
    Journal of medical virology, 2022, Volume: 94, Issue:6

    Topics: Amantadine; Animals; Antiviral Agents; Birds; Drug Resistance, Viral; Humans; Influenza A Virus, H5N

2022
Amantadine resistance markers among low pathogenic avian influenza H9N2 viruses isolated from poultry in India, during 2009-2017.
    Microbial pathogenesis, 2019, Volume: 137

    Topics: Amantadine; Animals; Antiviral Agents; Birds; Chickens; Drug Resistance, Viral; Genetic Markers; Ind

2019
Zataria multiflora essential oil reduces replication rate of avian influenza virus (H9N2 subtype) in challenged broiler chicks.
    British poultry science, 2018, Volume: 59, Issue:4

    Topics: Amantadine; Animal Feed; Animals; Antiviral Agents; Chickens; Diet; Dietary Supplements; Dose-Respon

2018
Magnetic-assisted biotinylated single-chain variable fragment antibody-based immunoassay for amantadine detection in chicken.
    Analytical and bioanalytical chemistry, 2018, Volume: 410, Issue:24

    Topics: Amantadine; Animals; Antiviral Agents; Biotin; Chickens; Chromatography, High Pressure Liquid; Cross

2018
Characterization of the amantadine-resistant H5N1 highly pathogenic avian influenza variants isolated from quails in Southern China.
    Virus genes, 2014, Volume: 49, Issue:2

    Topics: Amantadine; Animals; Antiviral Agents; China; Cluster Analysis; Drug Resistance, Viral; Evolution, M

2014
Emergence of Val27Ala mutation in M2 protein associated with amantadine resistance in highly pathogenic avian influenza H5N1 viruses in India.
    Acta virologica, 2014, Volume: 58, Issue:4

    Topics: Amantadine; Animals; Antiviral Agents; Birds; Drug Resistance, Viral; India; Influenza A Virus, H5N1

2014
Isolation and full genome characterization of avian influenza subtype H9N2 from poultry respiratory disease outbreak in Egypt.
    Virus genes, 2015, Volume: 50, Issue:3

    Topics: Amantadine; Animals; Antiviral Agents; Chickens; Cluster Analysis; Disease Outbreaks; Drug Resistanc

2015
The matrix gene of influenza A H5N1 in Egypt, 2006-2016: molecular insights and distribution of amantadine-resistant variants.
    Virus genes, 2016, Volume: 52, Issue:6

    Topics: Amantadine; Animals; Antiviral Agents; Chickens; Drug Resistance, Viral; Egypt; Genotype; History, 2

2016
Re-emergence of amantadine-resistant variants among highly pathogenic avian influenza H5N1 viruses in Egypt.
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2016, Volume: 46

    Topics: Amantadine; Animals; Antiviral Agents; Drug Resistance, Viral; Egypt; Genetic Variation; Influenza A

2016
Biological fitness and natural selection of amantadine resistant variants of avian influenza H5N1 viruses.
    Virus research, 2017, 01-15, Volume: 228

    Topics: Amantadine; Animals; Antiviral Agents; Cell Line; Chickens; Drug Resistance, Viral; Egypt; Genetic F

2017
Emergence of amantadine-resistant H3N2 avian influenza A virus in South Korea.
    Journal of clinical microbiology, 2008, Volume: 46, Issue:11

    Topics: Amantadine; Amino Acid Substitution; Animals; Antiviral Agents; Drug Resistance, Viral; Influenza A

2008
Detection of molecular markers of antiviral resistance in influenza A (H5N1) viruses using a pyrosequencing method.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:3

    Topics: Amantadine; Animals; Antiviral Agents; Birds; Drug Resistance, Viral; Genetic Markers; Humans; Influ

2009
Evolution analysis of the matrix (M) protein genes of 17 H9N2 chicken influenza viruses isolated in northern China during 1998-2008.
    Virus genes, 2009, Volume: 38, Issue:3

    Topics: Amantadine; Amino Acid Substitution; Animals; Antiviral Agents; Chickens; China; Cluster Analysis; D

2009
The susceptibility of magpies to a highly pathogenic avian influenza virus subtype H5N1.
    Poultry science, 2010, Volume: 89, Issue:6

    Topics: Amantadine; Animals; Disease Susceptibility; Influenza A Virus, H5N1 Subtype; Influenza in Birds; Pa

2010
Emergence of amantadine-resistant avian influenza H5N1 virus in India.
    Virus genes, 2011, Volume: 42, Issue:1

    Topics: Amantadine; Amino Acid Substitution; Animals; Asparagine; Chickens; Disease Outbreaks; Drug Resistan

2011
[Detection of molecular markers of amantadine resistance in avian influenza viruses by pyrosequencing].
    Bing du xue bao = Chinese journal of virology, 2010, Volume: 26, Issue:5

    Topics: Amantadine; Animals; Antiviral Agents; Chickens; Drug Resistance, Viral; Influenza A virus; Influenz

2010
Avian influenza should be ruffling our feathers.
    The Lancet. Infectious diseases, 2004, Volume: 4, Issue:10

    Topics: Acetamides; Amantadine; Animals; Antiviral Agents; Asia, Eastern; Asia, Southeastern; Birds; Disease

2004
Molecular characterization of the complete genome of human influenza H5N1 virus isolates from Thailand.
    The Journal of general virology, 2005, Volume: 86, Issue:Pt 2

    Topics: Amantadine; Animals; Antiviral Agents; Chickens; Disease Outbreaks; Drug Resistance, Viral; Hemagglu

2005
Statement on influenza vaccination for the 2005-2006 season. An advisory committee statement.
    Canada communicable disease report = Releve des maladies transmissibles au Canada, 2005, Jun-15, Volume: 31, Issue:ACS-6

    Topics: Acetamides; Adolescent; Age Factors; Amantadine; Animals; Antiviral Agents; Canada; Child; Child, Pr

2005
Infectious diseases. Lapses worry bird flu experts.
    Science (New York, N.Y.), 2005, Jun-24, Volume: 308, Issue:5730

    Topics: Amantadine; Animals; Antiviral Agents; Asia; Chickens; Disease Outbreaks; Drug Resistance, Viral; Hu

2005
Utilization of the embryonated egg for in vivo evaluation of the anti-influenza virus activity of neuraminidase inhibitors.
    Medical microbiology and immunology, 2006, Volume: 195, Issue:2

    Topics: Acetamides; Amantadine; Animals; Antiviral Agents; Chick Embryo; Chickens; Enzyme Inhibitors; Guanid

2006
Detection of amantadine-resistant variants among avian influenza viruses isolated in North America and Asia.
    Virology, 2005, Oct-10, Volume: 341, Issue:1

    Topics: Amantadine; Animals; Antiviral Agents; Asia, Southeastern; Cell Line; Dogs; Drug Resistance, Viral;

2005
Distribution of amantadine-resistant H5N1 avian influenza variants in Asia.
    The Journal of infectious diseases, 2006, Jun-15, Volume: 193, Issue:12

    Topics: Amantadine; Amino Acid Substitution; Animals; Antiviral Agents; Asia; Birds; Drug Resistance, Viral;

2006
[Report of the first human case of H5N1 avian influenza pneumonia in Hunan, China].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2006, Volume: 44, Issue:5

    Topics: Amantadine; Animals; Antibodies, Viral; Antiviral Agents; Birds; Child; China; Glucocorticoids; Huma

2006
Statement on influenza vaccination for the 2006-2007 season. An Advisory Committee Statement (ACS).
    Canada communicable disease report = Releve des maladies transmissibles au Canada, 2006, Jun-15, Volume: 32, Issue:ACS-7

    Topics: Acetamides; Adolescent; Adult; Aged; Amantadine; Animals; Antiviral Agents; Canada; Child; Child, Pr

2006
Susceptibility of highly pathogenic A(H5N1) avian influenza viruses to the neuraminidase inhibitors and adamantanes.
    Antiviral research, 2007, Volume: 73, Issue:3

    Topics: Acids, Carbocyclic; Amantadine; Animals; Antiviral Agents; Base Sequence; Birds; Cyclopentanes; Drug

2007
Characterization of avian H9N2 influenza viruses from United Arab Emirates 2000 to 2003.
    Virology, 2007, Apr-25, Volume: 361, Issue:1

    Topics: Amantadine; Amino Acid Substitution; Animals; Antigens, Viral; Antiviral Agents; Chickens; Disease O

2007
New strain of influenza A virus (H5N1), Thailand.
    Emerging infectious diseases, 2007, Volume: 13, Issue:3

    Topics: Amantadine; Animals; Antigens, Viral; Antiviral Agents; Chickens; Disease Outbreaks; Genes, Viral; G

2007
Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern China.
    Antiviral research, 2008, Volume: 77, Issue:1

    Topics: Amantadine; Animals; Antiviral Agents; Base Sequence; Cell Line; Chickens; China; Drug Resistance, V

2008
Cooperation between the hemagglutinin of avian viruses and the matrix protein of human influenza A viruses.
    Journal of virology, 2002, Volume: 76, Issue:4

    Topics: Amantadine; Animals; Antiviral Agents; Cell Line; Dogs; Drug Resistance, Viral; Hemagglutinin Glycop

2002
Biologic potential of amantadine-resistant influenza A virus in an avian model.
    The Journal of infectious diseases, 1989, Volume: 159, Issue:6

    Topics: Amantadine; Animals; Chickens; Drug Resistance, Microbial; Female; Influenza A virus; Influenza in B

1989
Chemotherapy and vaccination: a possible strategy for the control of highly virulent influenza virus.
    Journal of virology, 1985, Volume: 55, Issue:1

    Topics: Adamantane; Amantadine; Animals; Chickens; Drug Resistance, Microbial; Influenza A virus; Influenza

1985