amantadine has been researched along with Altered Level of Consciousness in 15 studies
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "We observed the changes of seven patients with UWS of intracerebral hemorrhage after taking amantadine." | 7.96 | The use of amantadine in patients with unresponsive wakefulness syndrome after severe cerebral hemorrhage. ( Gao, Y; Liang, F; Liu, X; Ma, L; Yang, J; Yang, L; Zhang, Y, 2020) |
| "A paranoid schizophrenic patient developed the neuroleptic malignant syndrome after receiving three doses of fluphenazine HCl and two doses of thioridazine while he was recovering from major trauma." | 7.66 | A case of neuroleptic malignant syndrome successfully treated with amantadine. ( Boettger, ML; McCarron, MM; Peck, JJ, 1982) |
| "We observed the changes of seven patients with UWS of intracerebral hemorrhage after taking amantadine." | 3.96 | The use of amantadine in patients with unresponsive wakefulness syndrome after severe cerebral hemorrhage. ( Gao, Y; Liang, F; Liu, X; Ma, L; Yang, J; Yang, L; Zhang, Y, 2020) |
| "A paranoid schizophrenic patient developed the neuroleptic malignant syndrome after receiving three doses of fluphenazine HCl and two doses of thioridazine while he was recovering from major trauma." | 3.66 | A case of neuroleptic malignant syndrome successfully treated with amantadine. ( Boettger, ML; McCarron, MM; Peck, JJ, 1982) |
| "Amantadine has been shown to promote the rate of neurologic recovery for patients with traumatic disorders of consciousness when administered between 4 and 16 weeks, as demonstrated by a well-designed randomized control trial." | 3.54 | Pharmacology in Treatment of Patients with Disorders of Consciousness. ( Marino, MH, 2024) |
| "Amantadine was well-tolerated in children with acquired brain injury and demonstrates pharmacokinetics similar to those reported for healthy young adults." | 2.75 | Pharmacokinetics of amantadine in children with impaired consciousness due to acquired brain injury: preliminary findings using a sparse-sampling technique. ( Bean, J; McMahon, MA; Michaud, LJ; Vargus-Adams, JN; Vinks, AA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (13.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 7 (46.67) | 2.80 |
| Authors | Studies |
|---|---|
| Barra, ME | 1 |
| Edlow, BL | 1 |
| Brophy, GM | 1 |
| Carlson, JM | 1 |
| Lin, DJ | 1 |
| Marino, MH | 1 |
| Lee, S | 1 |
| Lee, HH | 1 |
| Lee, Y | 1 |
| Lee, J | 1 |
| Alkhachroum, A | 1 |
| Eliseyev, A | 1 |
| Der-Nigoghossian, CA | 1 |
| Rubinos, C | 1 |
| Kromm, JA | 1 |
| Mathews, E | 1 |
| Bauerschmidt, A | 1 |
| Doyle, K | 1 |
| Velasquez, A | 1 |
| Egbebike, JA | 1 |
| Calderon, AR | 1 |
| Roh, DJ | 1 |
| Park, S | 1 |
| Agarwal, S | 1 |
| Connolly, ES | 1 |
| Claassen, J | 1 |
| Gao, Y | 1 |
| Ma, L | 1 |
| Liang, F | 1 |
| Zhang, Y | 1 |
| Yang, L | 1 |
| Liu, X | 1 |
| Yang, J | 1 |
| Kondratieva, EA | 1 |
| Kondratev, SA | 1 |
| Denisova, AA | 1 |
| Ivanova, NE | 1 |
| Kondratiev, AN | 1 |
| Whyte, J | 1 |
| Nordenbo, AM | 1 |
| Kalmar, K | 1 |
| Merges, B | 1 |
| Bagiella, E | 1 |
| Chang, H | 1 |
| Yablon, S | 1 |
| Cho, S | 1 |
| Hammond, F | 1 |
| Khademi, A | 1 |
| Giacino, J | 1 |
| Gosseries, O | 1 |
| Charland-Verville, V | 1 |
| Thonnard, M | 1 |
| Bodart, O | 1 |
| Laureys, S | 1 |
| Demertzi, A | 1 |
| Estraneo, A | 1 |
| Pascarella, A | 1 |
| Moretta, P | 1 |
| Loreto, V | 1 |
| Trojano, L | 1 |
| McMahon, MA | 2 |
| Vargus-Adams, JN | 2 |
| Michaud, LJ | 2 |
| Bean, J | 2 |
| Vinks, AA | 1 |
| Cheliapina, MV | 1 |
| Sharova, EV | 1 |
| Zaĭtsev, OS | 1 |
| Neppe, VM | 1 |
| McCarron, MM | 1 |
| Boettger, ML | 1 |
| Peck, JJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Cerebrolysin on Prolonged Disorders of Consciousness in Patients With Hemorrhagic Stroke: A Pilot Study[NCT04427241] | Phase 4 | 12 participants (Anticipated) | Interventional | 2023-06-01 | Not yet recruiting | ||
| The Impact and Outcomes of Combined Cerebrolysin and Amantadine Sulfate Administration on Management of Patients With Traumatic Brain Injury in the ICU[NCT06052787] | Phase 3 | 150 participants (Anticipated) | Interventional | 2023-09-01 | Recruiting | ||
| Randomized Controlled Trial of Apomorphine in Severe Brain-injured Patients: a Double-blind Behavioral and Neuroimaging Study[NCT05213169] | Phase 2/Phase 3 | 48 participants (Anticipated) | Interventional | 2021-06-18 | Recruiting | ||
| Treating Severe Brain-injured Patients With Apomorphine: a Behavioral and Neuroimaging Study[NCT03623828] | Phase 2 | 8 participants (Actual) | Interventional | 2018-10-03 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for amantadine and Altered Level of Consciousness
| Article | Year |
|---|---|
Pharmacology in Treatment of Patients with Disorders of Consciousness.
Topics: Amantadine; Brain Injuries; Consciousness; Consciousness Disorders; Humans; Randomized Controlled Tr | 2024 |
Amantadine, apomorphine and zolpidem in the treatment of disorders of consciousness.
Topics: Amantadine; Apomorphine; Consciousness Disorders; Humans; Pyridines; Zolpidem | 2014 |
Amantadine, apomorphine and zolpidem in the treatment of disorders of consciousness.
Topics: Amantadine; Apomorphine; Consciousness Disorders; Humans; Pyridines; Zolpidem | 2014 |
Amantadine, apomorphine and zolpidem in the treatment of disorders of consciousness.
Topics: Amantadine; Apomorphine; Consciousness Disorders; Humans; Pyridines; Zolpidem | 2014 |
Amantadine, apomorphine and zolpidem in the treatment of disorders of consciousness.
Topics: Amantadine; Apomorphine; Consciousness Disorders; Humans; Pyridines; Zolpidem | 2014 |
3 trials available for amantadine and Altered Level of Consciousness
| Article | Year |
|---|---|
Medical complications during inpatient rehabilitation among patients with traumatic disorders of consciousness.
Topics: Adolescent; Adult; Aged; Amantadine; Brain Injuries; Consciousness Disorders; Dopamine Agents; Dose- | 2013 |
Effects of amantadine in children with impaired consciousness caused by acquired brain injury: a pilot study.
Topics: Adolescent; Age Factors; Amantadine; Brain Injuries; Child; Child, Preschool; Consciousness Disorder | 2009 |
Pharmacokinetics of amantadine in children with impaired consciousness due to acquired brain injury: preliminary findings using a sparse-sampling technique.
Topics: Adolescent; Amantadine; Brain Injuries; Child; Consciousness; Consciousness Disorders; Cross-Over St | 2010 |
10 other studies available for amantadine and Altered Level of Consciousness
| Article | Year |
|---|---|
Pharmacologic Therapies to Promote Recovery of Consciousness.
Topics: Adult; Amantadine; Consciousness; Consciousness Disorders; Humans; Recovery of Function | 2022 |
Prognostication in Prolonged and Chronic Disorders of Consciousness.
Topics: Amantadine; Chronic Disease; Consciousness; Consciousness Disorders; Electroencephalography; Humans; | 2023 |
Additive effect of cerebrolysin and amantadine on disorders of consciousness secondary to acquired brain injury: A retrospective case-control study.
Topics: Amantadine; Amino Acids; Brain Injuries; Case-Control Studies; Consciousness Disorders; Female; Huma | 2020 |
Additive effect of cerebrolysin and amantadine on disorders of consciousness secondary to acquired brain injury: A retrospective case-control study.
Topics: Amantadine; Amino Acids; Brain Injuries; Case-Control Studies; Consciousness Disorders; Female; Huma | 2020 |
Additive effect of cerebrolysin and amantadine on disorders of consciousness secondary to acquired brain injury: A retrospective case-control study.
Topics: Amantadine; Amino Acids; Brain Injuries; Case-Control Studies; Consciousness Disorders; Female; Huma | 2020 |
Additive effect of cerebrolysin and amantadine on disorders of consciousness secondary to acquired brain injury: A retrospective case-control study.
Topics: Amantadine; Amino Acids; Brain Injuries; Case-Control Studies; Consciousness Disorders; Female; Huma | 2020 |
EEG to detect early recovery of consciousness in amantadine-treated acute brain injury patients.
Topics: Amantadine; Brain; Brain Injuries, Traumatic; Consciousness Disorders; Dopamine Agents; Electroencep | 2020 |
The use of amantadine in patients with unresponsive wakefulness syndrome after severe cerebral hemorrhage.
Topics: Amantadine; Cerebral Hemorrhage; Consciousness Disorders; Humans; Persistent Vegetative State; Wakef | 2020 |
[Results of treatment with intravenous amantadine sulfate (PK-Merz) patients with chronic disorders of consciousness].
Topics: Amantadine; Consciousness; Consciousness Disorders; Humans; Persistent Vegetative State; Wakefulness | 2020 |
Clinical and electroencephalographic on-off effect of amantadine in chronic non-traumatic minimally conscious state.
Topics: Amantadine; Analgesics, Non-Narcotic; Brain Waves; Consciousness Disorders; Dose-Response Relationsh | 2015 |
[Clinical and electroencephalographic effects of amantadine sulfate (PK-Merz) on consciousness disorders due to the severe traumatic brain injury].
Topics: Adolescent; Adult; Amantadine; Brain Injuries; Consciousness Disorders; Electroencephalography; Huma | 2011 |
The neuroleptic malignant syndrome. A priority system.
Topics: Amantadine; Antipsychotic Agents; Basal Ganglia Diseases; Bromocriptine; Consciousness Disorders; Da | 1984 |
A case of neuroleptic malignant syndrome successfully treated with amantadine.
Topics: Adult; Amantadine; Consciousness Disorders; Fluphenazine; Humans; Male; Malignant Hyperthermia; Musc | 1982 |