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amantadine and Aggression

amantadine has been researched along with Aggression in 20 studies

amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source

Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.

Research Excerpts

ExcerptRelevanceReference
"Amantadine was well tolerated."6.70Case series: amantadine open-label treatment of impulsive and aggressive behavior in hospitalized children with developmental disabilities. ( Dourish, CT; King, BH; Snape, M; Wright, DM, 2001)
" Following repeated administration of the higher dose of IMI together with AMA, we observed an increase in clonidine-induced aggression in mice, and significant enhancement of D-amphetamine-induced locomotor hyperactivity, as well as phenylephrine-induced exploratory behavior, in rats."3.72The effect of combined treatment with imipramine and amantadine on the behavioral reactivity of central alpha1-adrenergic system in rats. ( Dziedzicka-Wasylewska, M; Faron-Górecka, A; Rogóz, Z; Solich, J, 2004)
" The drug does not possess an antidepressant action proper but activates the aggressive-defensive behaviour in experimental reserpine depression and reduces the provocation-induced aggressive behaviour in experimental haloperidol depression."3.66[Psychopharmacologic spectrum of melanostatin]. ( Klusha, VE; Kozlovskaia, MM; Svirskis, ShV; Val'dman, AV, 1980)
" A retrospective review of electronic medical records was conducted by researchers and data were collected on the following measures: ordered psycho-pharmacological agents, frequency, dosing and duration of orders, whether each administered psycho-pharmacological agent was started before or after psychiatric consultation, and psycho-pharmacological agents prescribed upon discharge."2.82A descriptive analysis of pharmacological management of aggression and/or agitation in patients with traumatic brain injury in a Southwest Virginia inpatient population. ( Kablinger, A; Lemelle, T; Rahmani, E; Sharp, H; Smarbafzadeh, E, 2022)
"Amantadine was well tolerated."2.70Case series: amantadine open-label treatment of impulsive and aggressive behavior in hospitalized children with developmental disabilities. ( Dourish, CT; King, BH; Snape, M; Wright, DM, 2001)
"Nortriptyline was reported in one study as superior for men with alcohol dependency on mean number of drinking days and on alcohol dependence, but not for severity of alcohol misuse or on the patient's or clinician's rating of drinking."2.46Pharmacological interventions for antisocial personality disorder. ( Duggan, C; Ferriter, M; Huband, N; Khalifa, N; Lieb, K; Stoffers, J; Völlm, BA, 2010)
"Amantadine has a growing body of evidence for the treatment of aggressive behavior in patients with traumatic brain injury, autism spectrum disorder, and developmental disability."1.43Adjunctive Amantadine Treatment for Aggressive Behavior in Children: A Series of Eight Cases. ( Loveland, JG; McGrane, IR; Zaluski, HJ, 2016)
"Two patients with advanced Huntington's disease manifested a marked increase in irritability and aggressiveness when treated with amantadine during an epidemic of influenza."1.27Adverse behavioral effects of amantadine therapy in Huntington's disease. ( Stewart, JT, 1987)
"3) Amantadine was equipotent to imipramine in suppressing haloperidol-induced catalepsy in rats, but L-DOPA was without effect."1.27[Behavioral pharmacology of amantadine with special references to the effect on abnormal behavior in mice and rats]. ( Fujiwara, M; Kiyota, Y; Ohta, H; Sakurai, Y; Shibata, S; Shimazoe, T; Ueki, S, 1985)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19909 (45.00)18.7374
1990's0 (0.00)18.2507
2000's5 (25.00)29.6817
2010's4 (20.00)24.3611
2020's2 (10.00)2.80

Authors

AuthorsStudies
Rahmani, E1
Lemelle, T1
Sharp, H1
Smarbafzadeh, E1
Kablinger, A1
Khalifa, NR1
Gibbon, S1
Völlm, BA2
Cheung, NH1
McCarthy, L1
Gwynette, MF1
Beck, B1
VandenBerg, A1
Stocking, N1
Luauté, J1
Plantier, D1
Wiart, L1
Tell, L1
McGrane, IR1
Loveland, JG1
Zaluski, HJ1
Khalifa, N1
Duggan, C1
Stoffers, J1
Huband, N1
Ferriter, M1
Lieb, K1
Fleminger, S2
Greenwood, RJ2
Oliver, DL2
Dziedzicka-Wasylewska, M1
Faron-Górecka, A1
Rogóz, Z1
Solich, J1
Sugden, SG1
Kile, SJ1
Farrimond, DD1
Hilty, DM1
Bourgeois, JA1
Val'dman, AV1
Kozlovskaia, MM1
Klusha, VE1
Svirskis, ShV1
King, BH1
Wright, DM1
Snape, M1
Dourish, CT1
Pradhan, SN1
Anand, M1
Gupta, GP1
Bhargava, KP1
Senault, B1
Sulcová, A2
Gulda, O2
Krsiak, M1
Masek, K1
Stewart, JT1
Fujiwara, M1
Sakurai, Y1
Kiyota, Y1
Shimazoe, T1
Ohta, H1
Shibata, S1
Ueki, S1
Rizzo, M1
Morselli, PL1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Fluoxetine on Measures of Domestic Violence[NCT00011765]Phase 2104 participants (Actual)Interventional2001-02-22Completed
Medication Development for Cocaine Dependence[NCT00249691]Phase 3180 participants (Anticipated)Interventional2005-10-31Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for amantadine and Aggression

ArticleYear
A descriptive analysis of pharmacological management of aggression and/or agitation in patients with traumatic brain injury in a Southwest Virginia inpatient population.
    Journal of clinical pharmacy and therapeutics, 2022, Volume: 47, Issue:12

    Topics: Adrenergic beta-Antagonists; Adult; Aggression; Amantadine; Anticonvulsants; Antipsychotic Agents; B

2022
Pharmacological interventions for antisocial personality disorder.
    The Cochrane database of systematic reviews, 2020, 09-03, Volume: 9

    Topics: Adult; Aggression; Alcohol-Related Disorders; Amantadine; Antisocial Personality Disorder; Anxiety;

2020
Pharmacological interventions for antisocial personality disorder.
    The Cochrane database of systematic reviews, 2020, 09-03, Volume: 9

    Topics: Adult; Aggression; Alcohol-Related Disorders; Amantadine; Antisocial Personality Disorder; Anxiety;

2020
Pharmacological interventions for antisocial personality disorder.
    The Cochrane database of systematic reviews, 2020, 09-03, Volume: 9

    Topics: Adult; Aggression; Alcohol-Related Disorders; Amantadine; Antisocial Personality Disorder; Anxiety;

2020
Pharmacological interventions for antisocial personality disorder.
    The Cochrane database of systematic reviews, 2020, 09-03, Volume: 9

    Topics: Adult; Aggression; Alcohol-Related Disorders; Amantadine; Antisocial Personality Disorder; Anxiety;

2020
Care management of the agitation or aggressiveness crisis in patients with TBI. Systematic review of the literature and practice recommendations.
    Annals of physical and rehabilitation medicine, 2016, Volume: 59, Issue:1

    Topics: Adrenergic beta-Antagonists; Aggression; Amantadine; Anti-Anxiety Agents; Anticonvulsants; Antipsych

2016
Pharmacological interventions for antisocial personality disorder.
    The Cochrane database of systematic reviews, 2010, Aug-04, Issue:8

    Topics: Adult; Aggression; Alcohol-Related Disorders; Amantadine; Antisocial Personality Disorder; Anxiety;

2010
Pharmacological management for agitation and aggression in people with acquired brain injury.
    The Cochrane database of systematic reviews, 2003, Issue:1

    Topics: Adrenergic beta-Antagonists; Aggression; Amantadine; Anxiety; Brain Injuries; Humans; Methylphenidat

2003
Pharmacological management for agitation and aggression in people with acquired brain injury.
    The Cochrane database of systematic reviews, 2006, Oct-18, Issue:4

    Topics: Adrenergic beta-Antagonists; Aggression; Amantadine; Anxiety; Brain Injuries; Humans; Methylphenidat

2006
Aggression and central neurotransmitters.
    International review of neurobiology, 1975, Volume: 18

    Topics: Acetylcholinesterase; Aggression; Amantadine; Animals; Apomorphine; Brain; Carbachol; Choline O-Acet

1975

Trials

1 trial available for amantadine and Aggression

ArticleYear
Case series: amantadine open-label treatment of impulsive and aggressive behavior in hospitalized children with developmental disabilities.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2001, Volume: 40, Issue:6

    Topics: Aggression; Amantadine; Brain Diseases; Child; Child, Preschool; Developmental Disabilities; Disrupt

2001

Other Studies

12 other studies available for amantadine and Aggression

ArticleYear
Under arrest: the use of amantadine for treatment-refractory mood lability and aggression in a patient with traumatic brain injury.
    Journal of clinical psychopharmacology, 2015, Volume: 35, Issue:1

    Topics: Aggression; Amantadine; Brain Injuries; Criminals; Dopamine Agents; Humans; Male; Middle Aged; Mood

2015
Adjunctive Amantadine Treatment for Aggressive Behavior in Children: A Series of Eight Cases.
    Journal of child and adolescent psychopharmacology, 2016, Volume: 26, Issue:10

    Topics: Aggression; Amantadine; Child; Dopamine Agents; Dose-Response Relationship, Drug; Female; Humans; In

2016
The effect of combined treatment with imipramine and amantadine on the behavioral reactivity of central alpha1-adrenergic system in rats.
    Behavioural pharmacology, 2004, Volume: 15, Issue:2

    Topics: Administration, Oral; Adrenergic alpha-1 Receptor Agonists; Aggression; Amantadine; Amphetamine; Ani

2004
Pharmacological intervention for cognitive deficits and aggression in frontal lobe injury.
    NeuroRehabilitation, 2006, Volume: 21, Issue:1

    Topics: Adult; Aggression; Amantadine; Cognition Disorders; Conduct Disorder; Donepezil; Frontal Lobe; Human

2006
[Psychopharmacologic spectrum of melanostatin].
    Biulleten' eksperimental'noi biologii i meditsiny, 1980, Volume: 89, Issue:6

    Topics: Aggression; Amantadine; Animals; Behavior, Animal; Biogenic Amines; Brain Chemistry; Catalepsy; Cats

1980
Modification of electroshock fighting by drugs known to interact with dopaminergic and noradrenergic neurons in normal and brain lesioned rats.
    The Journal of pharmacy and pharmacology, 1977, Volume: 29, Issue:7

    Topics: Aggression; Amantadine; Animals; Apomorphine; Brain; Ditiocarb; Dopamine; Electroshock; Humans; Imip

1977
[Amantadine: aggressive effect; effect on apomorphine-induced aggressivity in the rat].
    Psychopharmacologia, 1976, Mar-16, Volume: 46, Issue:2

    Topics: Aggression; Amantadine; Animals; Apomorphine; Dose-Response Relationship, Drug; Humans; Rats

1976
The immunomodulators levamisole, muramyl dipeptide and adamantylamide dipeptide antagonize the antianxiety effect of diazepam.
    Activitas nervosa superior, 1989, Volume: 31, Issue:2

    Topics: Acetylmuramyl-Alanyl-Isoglutamine; Aggression; Agonistic Behavior; Amantadine; Animals; Anti-Anxiety

1989
Behavioural effects of muramyl dipeptide and adamantylamide dipeptide in mice.
    Activitas nervosa superior, 1989, Volume: 31, Issue:2

    Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Aggression; Agonistic Behavior; Amantadin

1989
Adverse behavioral effects of amantadine therapy in Huntington's disease.
    Southern medical journal, 1987, Volume: 80, Issue:10

    Topics: Adult; Aggression; Amantadine; Humans; Huntington Disease; Influenza, Human; Male

1987
[Behavioral pharmacology of amantadine with special references to the effect on abnormal behavior in mice and rats].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1985, Volume: 85, Issue:4

    Topics: Aggression; Amantadine; Animals; Behavior, Animal; Catalepsy; Central Nervous System; Dronabinol; Ha

1985
Amantadine-induced aggressiveness.
    British medical journal, 1972, Jul-01, Volume: 3, Issue:5817

    Topics: Aged; Aggression; Amantadine; Depression; Humans; Motor Activity

1972