amanitins has been researched along with Hypothyroidism* in 4 studies
4 other study(ies) available for amanitins and Hypothyroidism
| Article | Year |
|---|---|
Effect of triiodothyronine on deoxyribonucleic acid-dependent ribonucleic acid polymerase function in rat liver nuclei.
Topics: Amanitins; Animals; Cell Nucleus; DNA-Directed DNA Polymerase; Hypothyroidism; Kinetics; Liver; Male; Rats; RNA Polymerase I; RNA Polymerase II; Templates, Genetic; Triiodothyronine | 1980 |
Triiodothyronine stimulates nuclear RNA synthesis.
Topics: Amanitins; Animals; Cell Nucleus; Cycloheximide; DNA-Directed RNA Polymerases; Hypothyroidism; Kinetics; Liver; Male; Poly A; Rats; RNA; Triiodothyronine | 1977 |
Alpha-amanitin administration results in a temporary inhibition of hepatic enzyme induction by triiodothyronine: further evidence favoring a long-lived mediator of thyroid hormone action.
Alpha-amanitin was shown to inhibit triiodothyronine (T3)-induced increases in mitochondrial alpha-glycerophosphate dehydrogenase (alpha-GPD) and cytoplasmic malic enzyme activity in the livers of male Sprague-Dawley rats. A 3-fold increase in alpha-GPD observed 24 h after the iv injection of 3 microngT3/100 g BW was completely inhibited by administration of alpha-amanitin at 0 and 8 h. Similarly, alpha-amanitin blocked a two- to four-fold increase in malic enzyme 24 h following iv injection of 3 mg T3/100 g BW into euthyroid rats. After the initial inhibition of enzyme induction by alpha-amanitin was dissipated, however, a delayed but striking increase in enzyme activity occurred. In hypothyroid animals, alpha-GPD activity rose after the initial 24 h inhibition and reached levels at 72 h equal to those observed in hypothyroid rats treated with T3 only. In euthyroid animals treated with T3 and alpha-amanitin, a delayed increase in malic enzyme activity was observed at 72 h and attained values at 96 h similar to those in euthyroid animals injected with T3 only. The delayed rise in enzyme response is most easily explained by the formation of a long-lived intermediate during the exposure of the nuclear sites to T3. Topics: Amanitins; Animals; Enzyme Induction; Glycerolphosphate Dehydrogenase; Hypothyroidism; Liver; Long-Acting Thyroid Stimulator; Malate Dehydrogenase; Male; Rats; Time Factors; Triiodothyronine | 1977 |
Influence of neonatal hypothyroidism upon transcription in isolated rat brain and liver nuclei.
Topics: Amanitins; Animals; Animals, Newborn; Body Weight; Brain; Cell Nucleus; Dactinomycin; DNA; DNA-Directed RNA Polymerases; Female; Hypothyroidism; Kinetics; Liver; Magnesium; Male; Manganese; Organ Size; Organ Specificity; Osmolar Concentration; Rats; Thyroidectomy; Transcription, Genetic | 1976 |