amanitins and Hepatitis-B

Side effects of antiviral drugs might be circumvented by their selective delivery into infected cells. This targeting can be obtained by conjugation of the drugs to macromolecules which are taken up specifically by the infected cells. The experiments reviewed, on this approach to antiviral chemotherapy, are mainly directed at improving the chemotherapeutic index of adenine arabinoside (ara-A) in the treatment of chronic hepatitis B by its coupling to galactosyl terminating glycoproteins.

Topics: Albumins; alpha-Fetoproteins; Amanitins; Amino Sugars; Animals; Antiviral Agents; Asialoglycoproteins; Chemical Phenomena; Chemistry; Cytarabine; DNA Replication; Ectromelia virus; Fetuins; Floxuridine; Glycoproteins; Hepatitis B; Hepatitis B virus; Humans; Liver; Macrophages; Serum Albumin; Trifluridine; Vidarabine; Virus Replication