amanitins and Blood-Coagulation-Disorders

The authors describe frequency and importance of poisoning by Amanita phalloides. There are demonstrated the different toxins and their biochemical properties. The typical clinical symptoms of the intoxication by Amanita phalloides with vourse in two phases (1. gastrointestinal phase, 2. hepatonephrotic phase) are shown. The possibilities of diagnostic and differentialdiagnostic and the problems of therapy are discussed. It is pointed out, that in a modern treatment there must be given Penicillin-G-Natrium in high dosage as early as possible, also in cases of questionableness. Hemodialysis is only of effect till 40 hours after ingestion of Amanita.

Topics: Amanita; Amanitins; Blood Coagulation Disorders; Child; Diagnosis, Differential; Female; Hepatic Encephalopathy; Humans; Mushroom Poisoning; Penicillin G

Topics: Amanitins; Bile; Blood Coagulation Disorders; Charcoal; Enterohepatic Circulation; Filtration; Gastric Lavage; Hemoperfusion; Humans; Intestinal Secretions; Liver; Liver Regeneration; Mushroom Poisoning; Renal Dialysis; RNA Polymerase II; RNA Polymerase III; RNA, Messenger; Silymarin; Thioctic Acid; Time; Transcription, Genetic