am-630 and Hypersensitivity

The generation of functional regulatory T cells (Tregs) is essential to keep tissue homeostasis and restore healthy immune responses in many biological and inflammatory contexts. Cannabinoids have been pointed out as potential therapeutic tools for several diseases. Dendritic cells (DCs) express the endocannabinoid system, including the cannabinoid receptors CB1 and CB2. However, how cannabinoids might regulate functional properties of DCs is not completely understood. We uncover that the triggering of cannabinoid receptors promote human tolerogenic DCs that are able to prime functional FOXP3

Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents; Autophagy; Cannabinoids; Cells, Cultured; Cellular Reprogramming; Coculture Techniques; Dendritic Cells; Humans; Hypersensitivity; Immune Tolerance; Indoles; Mice; Oxidative Phosphorylation; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction; T-Lymphocytes, Regulatory; Th1-Th2 Balance