am-630 and Facial-Pain

This study was conducted with the aim of evaluating whether electroacupuncture (EA) at acupoint St36 could produce antinociception through the activation of an endocannabinoid mechanism.. Male Wistar rats were divided into experimental groups. Heat was applied to the faces of rats, and the latency to withdraw the face was measured. Furthermore, the influence of electrical stimulation (100HzP) of acupoint St36, at a 0.5mA intensity, was investigated in the facial withdrawal threshold.. The EA produced antinociception, which lasted for 180min. This effect was antagonized by the pre-injection of AM 251, a CB. This study demonstrated for the first time that the CB1 cannabinoid receptor participates in the antinociceptive effect induced by EA.

Topics: Acupuncture Points; Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Electroacupuncture; Endocannabinoids; Facial Pain; Indoles; Male; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar