am 580 has been researched along with Hormone-Dependent Neoplasms in 2 studies
Am 580: a selctive retinoic acid receptor (alpha) agonist; structure given in first source
4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid : An amidobenzoic acid obtained by formal condensation of the carboxy group of (5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzoic acid with the anilino group of 4-aminobenzoic acid. A selective RARalpha agonist.
| Excerpt | Relevance | Reference |
|---|---|---|
| "RAR-agonists did not stimulate SOX9 in breast cancer cell lines which were not growth inhibited by retinoids." | 1.31 | RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition. ( Afonja, O; Das, S; Helmer, E; Huang, A; Juste, D; Raaka, BM; Samuels, HH; Zhao, X, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Afonja, O | 1 |
| Raaka, BM | 1 |
| Huang, A | 1 |
| Das, S | 1 |
| Zhao, X | 1 |
| Helmer, E | 1 |
| Juste, D | 1 |
| Samuels, HH | 1 |
| Cho, Y | 1 |
| Tighe, AP | 1 |
| Talmage, DA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Observational Study on the Carcinogenesis of SOX-9 in Oral Cancer, and Chemopreventive Possibility for the Treatment of Oral Cancer Using SOX-9 Inhibitor.[NCT01919567] | 255 participants (Anticipated) | Observational | 2011-11-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for am 580 and Hormone-Dependent Neoplasms
| Article | Year |
|---|---|
RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition.
Topics: Animals; Benzoates; Breast Neoplasms; Cell Cycle; Cell Division; Estradiol; Estrogens; Expressed Seq | 2002 |
Retinoic acid induced growth arrest of human breast carcinoma cells requires protein kinase C alpha expression and activity.
Topics: Benzoates; Blotting, Northern; Blotting, Western; Breast Neoplasms; Cell Division; Dose-Response Rel | 1997 |