am 580 has been researched along with Acute Promyelocytic Leukemia in 7 studies
Am 580: a selctive retinoic acid receptor (alpha) agonist; structure given in first source
4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid : An amidobenzoic acid obtained by formal condensation of the carboxy group of (5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzoic acid with the anilino group of 4-aminobenzoic acid. A selective RARalpha agonist.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the NB4 model of acute promyelocytic leukemia (APL), ATRA, 9-cis retinoic acid (9-cis RA), the pan-RAR and RARalpha-selective agonists, TTNPB and AM580, induce growth inhibition, granulocytic differentiation and apoptosis." | 1.31 | Retinoid-dependent growth inhibition, differentiation and apoptosis in acute promyelocytic leukemia cells. Expression and activation of caspases. ( Garattini, E; Gianni, M; Mologni, L; Ponzanelli, I; Rambaldi, A; Reichert, U; Terao, M, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kagechika, H | 2 |
| Himi, T | 2 |
| Kawachi, E | 2 |
| Shudo, K | 2 |
| Hashimoto, Y | 1 |
| Perri, M | 1 |
| Yap, JL | 1 |
| Yu, J | 1 |
| Cione, E | 1 |
| Fletcher, S | 1 |
| Kane, MA | 1 |
| Gianní, M | 2 |
| Li Calzi, M | 1 |
| Terao, M | 2 |
| Guiso, G | 1 |
| Caccia, S | 1 |
| Barbui, T | 1 |
| Rambaldi, A | 2 |
| Garattini, E | 2 |
| Benedetti, L | 1 |
| Grignani, F | 1 |
| Scicchitano, BM | 1 |
| Jetten, AM | 1 |
| Diverio, D | 1 |
| Lo Coco, F | 1 |
| Avvisati, G | 1 |
| Gambacorti-Passerini, C | 1 |
| Adamo, S | 1 |
| Levin, AA | 1 |
| Pelicci, PG | 1 |
| Nervi, C | 1 |
| Shibakura, M | 1 |
| Koyama, T | 1 |
| Ohsawa, M | 1 |
| Kamiyama, R | 1 |
| Hirosawa, S | 1 |
| Ponzanelli, I | 1 |
| Mologni, L | 1 |
| Reichert, U | 1 |
7 other studies available for am 580 and Acute Promyelocytic Leukemia
| Article | Year |
|---|---|
Retinobenzoic acids. 4. Conformation of aromatic amides with retinoidal activity. Importance of trans-amide structure for the activity.
Topics: Amides; Benzoates; Cell Differentiation; Cell Line; Humans; Leukemia, Promyelocytic, Acute; Magnetic | 1989 |
Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity.
Topics: Amides; Binding Sites; Cell Differentiation; Humans; Leukemia, Promyelocytic, Acute; Methylation; Mo | 1988 |
BCL-xL/MCL-1 inhibition and RARγ antagonism work cooperatively in human HL60 leukemia cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-X Protein; Benzamides; Benzoates; Blo | 2014 |
AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells.
Topics: Alkaline Phosphatase; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antineoplastic Agents | 1996 |
Retinoid-induced differentiation of acute promyelocytic leukemia involves PML-RARalpha-mediated increase of type II transglutaminase.
Topics: Apoptosis; Benzoates; CD18 Antigens; Cell Differentiation; Chromosomes, Human, Pair 15; Chromosomes, | 1996 |
A retinoic acid receptor-alpha (RAR alpha) selective agonist modulates procoagulant activity of acute promyelocytic cells and induces their differentiation into neutrophils.
Topics: Antineoplastic Agents; Benzoates; Blood Coagulation; Cell Differentiation; Humans; Leukemia, Promyel | 1998 |
Retinoid-dependent growth inhibition, differentiation and apoptosis in acute promyelocytic leukemia cells. Expression and activation of caspases.
Topics: Alitretinoin; Antineoplastic Agents; Apoptosis; Benzoates; Caspases; Cell Differentiation; Cell Divi | 2000 |