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am 580 and Acute Promyelocytic Leukemia

am 580 has been researched along with Acute Promyelocytic Leukemia in 7 studies

Am 580: a selctive retinoic acid receptor (alpha) agonist; structure given in first source
4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid : An amidobenzoic acid obtained by formal condensation of the carboxy group of (5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzoic acid with the anilino group of 4-aminobenzoic acid. A selective RARalpha agonist.

Research Excerpts

ExcerptRelevanceReference
"In the NB4 model of acute promyelocytic leukemia (APL), ATRA, 9-cis retinoic acid (9-cis RA), the pan-RAR and RARalpha-selective agonists, TTNPB and AM580, induce growth inhibition, granulocytic differentiation and apoptosis."1.31Retinoid-dependent growth inhibition, differentiation and apoptosis in acute promyelocytic leukemia cells. Expression and activation of caspases. ( Garattini, E; Gianni, M; Mologni, L; Ponzanelli, I; Rambaldi, A; Reichert, U; Terao, M, 2000)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19902 (28.57)18.7374
1990's3 (42.86)18.2507
2000's1 (14.29)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kagechika, H2
Himi, T2
Kawachi, E2
Shudo, K2
Hashimoto, Y1
Perri, M1
Yap, JL1
Yu, J1
Cione, E1
Fletcher, S1
Kane, MA1
Gianní, M2
Li Calzi, M1
Terao, M2
Guiso, G1
Caccia, S1
Barbui, T1
Rambaldi, A2
Garattini, E2
Benedetti, L1
Grignani, F1
Scicchitano, BM1
Jetten, AM1
Diverio, D1
Lo Coco, F1
Avvisati, G1
Gambacorti-Passerini, C1
Adamo, S1
Levin, AA1
Pelicci, PG1
Nervi, C1
Shibakura, M1
Koyama, T1
Ohsawa, M1
Kamiyama, R1
Hirosawa, S1
Ponzanelli, I1
Mologni, L1
Reichert, U1

Other Studies

7 other studies available for am 580 and Acute Promyelocytic Leukemia

ArticleYear
Retinobenzoic acids. 4. Conformation of aromatic amides with retinoidal activity. Importance of trans-amide structure for the activity.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:10

    Topics: Amides; Benzoates; Cell Differentiation; Cell Line; Humans; Leukemia, Promyelocytic, Acute; Magnetic

1989
Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:11

    Topics: Amides; Binding Sites; Cell Differentiation; Humans; Leukemia, Promyelocytic, Acute; Methylation; Mo

1988
BCL-xL/MCL-1 inhibition and RARγ antagonism work cooperatively in human HL60 leukemia cells.
    Experimental cell research, 2014, Oct-01, Volume: 327, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-X Protein; Benzamides; Benzoates; Blo

2014
AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells.
    Blood, 1996, Feb-15, Volume: 87, Issue:4

    Topics: Alkaline Phosphatase; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antineoplastic Agents

1996
Retinoid-induced differentiation of acute promyelocytic leukemia involves PML-RARalpha-mediated increase of type II transglutaminase.
    Blood, 1996, Mar-01, Volume: 87, Issue:5

    Topics: Apoptosis; Benzoates; CD18 Antigens; Cell Differentiation; Chromosomes, Human, Pair 15; Chromosomes,

1996
A retinoic acid receptor-alpha (RAR alpha) selective agonist modulates procoagulant activity of acute promyelocytic cells and induces their differentiation into neutrophils.
    Blood, 1998, Jan-15, Volume: 91, Issue:2

    Topics: Antineoplastic Agents; Benzoates; Blood Coagulation; Cell Differentiation; Humans; Leukemia, Promyel

1998
Retinoid-dependent growth inhibition, differentiation and apoptosis in acute promyelocytic leukemia cells. Expression and activation of caspases.
    Cell death and differentiation, 2000, Volume: 7, Issue:5

    Topics: Alitretinoin; Antineoplastic Agents; Apoptosis; Benzoates; Caspases; Cell Differentiation; Cell Divi

2000