am 580 has been researched along with Abnormalities, Drug-Induced in 5 studies
Am 580: a selctive retinoic acid receptor (alpha) agonist; structure given in first source
4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid : An amidobenzoic acid obtained by formal condensation of the carboxy group of (5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzoic acid with the anilino group of 4-aminobenzoic acid. A selective RARalpha agonist.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Elmazar, MM | 4 |
| Nau, H | 4 |
| Eckhardt, K | 1 |
| Schmitt, G | 1 |
| Reichert, U | 2 |
| Shroot, B | 2 |
| Arafa, HM | 1 |
| Hamada, FM | 1 |
| Rühl, R | 1 |
5 other studies available for am 580 and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Potentiation of the teratogenic effects induced by coadministration of retinoic acid or phytanic acid/phytol with synthetic retinoid receptor ligands.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Benzoates; Bexarotene; Dose-Response Rel | 2004 |
A retinoic acid receptor alpha antagonist counteracts retinoid teratogenicity in vitro and reduced incidence and/or severity of malformations in vivo.
Topics: Abnormalities, Drug-Induced; Animals; Benzoates; Cell Differentiation; Cells, Cultured; Chromans; Cl | 1994 |
Pattern of retinoid-induced teratogenic effects: possible relationship with relative selectivity for nuclear retinoid receptors RAR alpha, RAR beta, and RAR gamma.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Administration, Oral; Animals; Benzoates; Bone | 1996 |
Selective agonists of retinoic acid receptors: comparative toxicokinetics and embryonic exposure.
Topics: Abnormalities, Drug-Induced; Animals; Area Under Curve; Benzoates; Embryo, Mammalian; Female; Matern | 2000 |
Synergistic teratogenic effects induced by retinoids in mice by coadministration of a RARalpha- or RARgamma-selective agonist with a RXR-selective agonist.
Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Benzoates; Drug Synergism; Fetus; Male; | 2001 |