am-404 and Respiratory-Insufficiency

Endocannabinoids (ECs) are bioactive lipid mediators acting on two distinct cannabinoid receptors (CB1 and CB2), which are ubiquitously expressed in many tissues including the respiratory system. Despite numerous experimental data showing that cannabinomimetics influence respiration, the role of endogenously produced ECs in respiratory control has not been verified yet. Pulse oximetry was used in the present study to directly measure changes in respiratory parameters during elevation of EC levels. The cannabinoid reuptake inhibitor AM-404 (10mgkg

Topics: Animals; Arachidonic Acids; Endocannabinoids; Heart Rate; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oximetry; Oxygen Consumption; Receptor, Cannabinoid, CB1; Respiration; Respiratory Insufficiency; Time Factors