am-404 and Morphine-Dependence

am-404 has been researched along with Morphine-Dependence* in 1 studies

Other Studies

1 other study(ies) available for am-404 and Morphine-Dependence

Article	Year
Attenuation of spontaneous opiate withdrawal in mice by the anandamide transport inhibitor AM404. European journal of pharmacology, 2002, Nov-01, Volume: 454, Issue:1 The endogenous cannabinoid, anandamide, has been shown to attenuate naloxone-precipitated opiate withdrawal in rodents. Here we show that the spontaneous, but not the naloxone-precipitated withdrawal syndrome in morphine-dependent mice is attenuated by the inhibitor of carrier-mediated anandamide transport N-(4-hydroxyphenyl) arachidonylethanolamide (AM404) (2 and 10 mg/kg, i.p.). These results suggest that spontaneous but not opioid antagonist-precipitated withdrawal is associated with dynamic changes in endogenous cannabinoid signaling. Topics: Animals; Arachidonic Acids; Biological Transport; Depression, Chemical; Dose-Response Relationship, Drug; Endocannabinoids; Mice; Morphine Dependence; Naloxone; Narcotic Antagonists; Polyunsaturated Alkamides; Substance Withdrawal Syndrome	2002

Article

Year

Attenuation of spontaneous opiate withdrawal in mice by the anandamide transport inhibitor AM404.

European journal of pharmacology, 2002, Nov-01, Volume: 454, Issue:1

The endogenous cannabinoid, anandamide, has been shown to attenuate naloxone-precipitated opiate withdrawal in rodents. Here we show that the spontaneous, but not the naloxone-precipitated withdrawal syndrome in morphine-dependent mice is attenuated by the inhibitor of carrier-mediated anandamide transport N-(4-hydroxyphenyl) arachidonylethanolamide (AM404) (2 and 10 mg/kg, i.p.). These results suggest that spontaneous but not opioid antagonist-precipitated withdrawal is associated with dynamic changes in endogenous cannabinoid signaling.

Topics: Animals; Arachidonic Acids; Biological Transport; Depression, Chemical; Dose-Response Relationship, Drug; Endocannabinoids; Mice; Morphine Dependence; Naloxone; Narcotic Antagonists; Polyunsaturated Alkamides; Substance Withdrawal Syndrome

2002