am-356 and Periodontitis

am-356 has been researched along with Periodontitis* in 1 studies

Other Studies

1 other study(ies) available for am-356 and Periodontitis

ArticleYear
Long-term treatment with methanandamide attenuates LPS-induced periodontitis in rats.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012, Volume: 61, Issue:9

    Evidence exists of the anti-inflammatory and immunological properties of endocannabinoids in various tissues; the aim of the present study was therefore to assess the effect of long-term treatment with the synthetic cannabinoid methanandamide (Meth-AEA) on the progression of periodontitis in rats.. Periodontitis was induced by injecting LPS (1 mg/ml) into the gingiva around the neck of the first upper and lower molars, and into the inter-dental space between the first and second molars. This protocol was repeated for 6 weeks on days 1, 3, and 5 of each week.. Long-term treatment with topical Meth-AEA (500 ng/ml), applied daily to gingival tissue of rats induced with periodontitis, significantly diminished the alveolar bone loss, measured as the distance between the cemento-enamel junction and the alveolar crest, in both maxillary and mandibular first molars, compared to rats without treatment (P < 0.05). The treatment also reduced the production of some biological mediators of periodontal disease augmented by LPS, such as tumor necrosis factor alpha (from 119.4 ± 9.9 pg/mg protein to 75.1 ± 10.8, P < 0.05) and nitric oxide produced by inducible nitric oxide synthase (from 507.7 ± 107.1 pmol/min/mg protein to 163.1 ± 53.9, P < 0.01).. These results demonstrate the beneficial effects of treatment with Meth-AEA on gingival tissue of rats with periodontitis.

    Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents; Arachidonic Acids; Dinoprostone; Disease Models, Animal; In Vitro Techniques; Lipopolysaccharides; Male; Nitric Oxide Synthase Type II; Periodontitis; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Tumor Necrosis Factor-alpha

2012