am 251 has been researched along with Weight Loss in 3 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Weight Loss: Decrease in existing BODY WEIGHT.
| Excerpt | Relevance | Reference |
|---|---|---|
| " rimonabant, AM 251) on food intake and weight gain in rodents, surprisingly little is known about the behavioural selectivity of such effects." | 3.74 | Acute anorectic response to cannabinoid CB1 receptor antagonist/inverse agonist AM 251 in rats: indirect behavioural mediation. ( Blundell, JE; Rodgers, JR; Tallett, AJ, 2007) |
| "Weight loss was greater with AM251 than could be accounted for by food restriction (∼25%), an effect likely mediated by the EE response to CB1R inhibition." | 1.38 | Cannabinoid-1 receptor inhibition prevents the reduction of 24-hour energy expenditure with weight loss. ( Achanfuo-Yeboah, J; Cunningham, PK; Faidley, T; Fong, TM; Heymsfield, SB; Hickey, G; Hora, D; Johnson-Levonas, AO; Nicolich, S; Strack, AM; Thompson, D, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Strack, AM | 1 |
| Nicolich, S | 1 |
| Faidley, T | 1 |
| Achanfuo-Yeboah, J | 1 |
| Cunningham, PK | 1 |
| Hora, D | 1 |
| Thompson, D | 1 |
| Hickey, G | 1 |
| Johnson-Levonas, AO | 1 |
| Fong, TM | 1 |
| Heymsfield, SB | 1 |
| Zhou, D | 1 |
| Shearman, LP | 1 |
| Tallett, AJ | 1 |
| Blundell, JE | 1 |
| Rodgers, JR | 1 |
1 trial available for am 251 and Weight Loss
| Article | Year |
|---|---|
Voluntary exercise augments acute effects of CB1-receptor inverse agonist on body weight loss in obese and lean mice.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Eating; Female; Mice; Mice, Inbred C57BL; Mi | 2004 |
2 other studies available for am 251 and Weight Loss
| Article | Year |
|---|---|
Cannabinoid-1 receptor inhibition prevents the reduction of 24-hour energy expenditure with weight loss.
Topics: Absorptiometry, Photon; Animals; Disease Models, Animal; Dogs; Eating; Energy Metabolism; Female; Gl | 2012 |
Acute anorectic response to cannabinoid CB1 receptor antagonist/inverse agonist AM 251 in rats: indirect behavioural mediation.
Topics: Animals; Appetite Depressants; Dose-Response Relationship, Drug; Drug Inverse Agonism; Eating; Feedi | 2007 |