am 251 has been researched along with Weight Gain in 8 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Weight Gain: Increase in BODY WEIGHT over existing weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our results indicate that the cannabinoid CB1 inverse agonist AM 251 represents a promising therapeutic strategy for the treatment of obesity and metabolic syndrome." | 7.79 | Novel effects of the cannabinoid inverse agonist AM 251 on parameters related to metabolic syndrome in obese Zucker rats. ( Aranda, P; Errami, M; Galisteo, M; Llopis, J; López-Chaves, C; López-Jurado, M; Martínez, R; Merroun, I; Porres, JM; Sánchez-González, C; Zarzuelo, A, 2013) |
| "Our results indicate that the cannabinoid CB1 inverse agonist AM 251 represents a promising therapeutic strategy for the treatment of obesity and metabolic syndrome." | 3.79 | Novel effects of the cannabinoid inverse agonist AM 251 on parameters related to metabolic syndrome in obese Zucker rats. ( Aranda, P; Errami, M; Galisteo, M; Llopis, J; López-Chaves, C; López-Jurado, M; Martínez, R; Merroun, I; Porres, JM; Sánchez-González, C; Zarzuelo, A, 2013) |
| " rimonabant, AM 251) on food intake and weight gain in rodents, surprisingly little is known about the behavioural selectivity of such effects." | 3.74 | Acute anorectic response to cannabinoid CB1 receptor antagonist/inverse agonist AM 251 in rats: indirect behavioural mediation. ( Blundell, JE; Rodgers, JR; Tallett, AJ, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Merroun, I | 1 |
| Sánchez-González, C | 1 |
| Martínez, R | 1 |
| López-Chaves, C | 1 |
| Porres, JM | 1 |
| Aranda, P | 1 |
| Llopis, J | 1 |
| Galisteo, M | 1 |
| Zarzuelo, A | 1 |
| Errami, M | 1 |
| López-Jurado, M | 1 |
| Wierucka-Rybak, M | 1 |
| Wolak, M | 1 |
| Juszczak, M | 1 |
| Drobnik, J | 1 |
| Bojanowska, E | 1 |
| Tallett, AJ | 2 |
| Blundell, JE | 2 |
| Rodgers, RJ | 1 |
| Riedel, G | 1 |
| Fadda, P | 1 |
| McKillop-Smith, S | 1 |
| Pertwee, RG | 1 |
| Platt, B | 1 |
| Robinson, L | 1 |
| Judge, MK | 1 |
| Zhang, Y | 1 |
| Scarpace, PJ | 1 |
| Crespillo, A | 2 |
| Suárez, J | 2 |
| Bermúdez-Silva, FJ | 2 |
| Rivera, P | 2 |
| Vida, M | 2 |
| Alonso, M | 1 |
| Palomino, A | 1 |
| Lucena, MA | 1 |
| Serrano, A | 2 |
| Pérez-Martín, M | 1 |
| Macias, M | 1 |
| Fernández-Llébrez, P | 1 |
| Rodríguez de Fonseca, F | 1 |
| Luque-Rojas, MJ | 1 |
| Pastor, A | 1 |
| Blanco, E | 1 |
| Pavón, FJ | 1 |
| Grondona, JM | 1 |
| Cifuentes, M | 1 |
| de la Torre, R | 1 |
| de Fonseca, FR | 1 |
| Rodgers, JR | 1 |
8 other studies available for am 251 and Weight Gain
| Article | Year |
|---|---|
Novel effects of the cannabinoid inverse agonist AM 251 on parameters related to metabolic syndrome in obese Zucker rats.
Topics: Animals; Biomarkers; Cannabinoid Receptor Antagonists; Eating; Energy Metabolism; Fatty Liver; Insul | 2013 |
The inhibitory effect of combination treatment with leptin and cannabinoid CB1 receptor agonist on food intake and body weight gain is mediated by serotonin 1B and 2C receptors.
Topics: Aminopyridines; Animals; Cannabinoid Receptor Agonists; Drug Synergism; Eating; Indoles; Leptin; Mal | 2016 |
Effects of acute low-dose combined treatment with naloxone and AM 251 on food intake, feeding behaviour and weight gain in rats.
Topics: Animals; Drug Interactions; Eating; Feeding Behavior; Grooming; Male; Motor Activity; Naloxone; Narc | 2009 |
Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice.
Topics: Animals; Appetite Depressants; Cannabinoid Receptor Antagonists; Dronabinol; Eating; Fasting; Feedin | 2009 |
Responses to the cannabinoid receptor-1 antagonist, AM251, are more robust with age and with high-fat feeding.
Topics: Age Factors; Animals; Appetite Depressants; Body Composition; Dietary Fats; Energy Intake; Hyperphag | 2009 |
Expression of the cannabinoid system in muscle: effects of a high-fat diet and CB1 receptor blockade.
Topics: Animals; Cannabinoids; Dietary Fats; Energy Intake; Gene Expression Regulation; Lipid Metabolism; Mu | 2011 |
Diet-dependent modulation of hippocampal expression of endocannabinoid signaling-related proteins in cannabinoid antagonist-treated obese rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Ant | 2013 |
Acute anorectic response to cannabinoid CB1 receptor antagonist/inverse agonist AM 251 in rats: indirect behavioural mediation.
Topics: Animals; Appetite Depressants; Dose-Response Relationship, Drug; Drug Inverse Agonism; Eating; Feedi | 2007 |