Page last updated: 2024-10-22

am 251 and Vomiting

am 251 has been researched along with Vomiting in 5 studies

AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.

Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.

Research Excerpts

ExcerptRelevanceReference
"The results suggest that prolonging the action of anandamide by pretreatment with the FAAH inhibitor, URB597, suppresses lithium-induced nausea in the rat."7.74Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat. ( Cross-Mellor, SK; Ossenkopp, KP; Parker, LA; Piomelli, D, 2007)
"Emesis was induced in ferrets with morphine-6-glucuronide (0."7.74A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient. ( Miller, MJ; Reuter, BK; Sharkey, KA; Wallace, JL, 2008)
"The results suggest that prolonging the action of anandamide by pretreatment with the FAAH inhibitor, URB597, suppresses lithium-induced nausea in the rat."3.74Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat. ( Cross-Mellor, SK; Ossenkopp, KP; Parker, LA; Piomelli, D, 2007)
"Emesis was induced in ferrets with morphine-6-glucuronide (0."3.74A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient. ( Miller, MJ; Reuter, BK; Sharkey, KA; Wallace, JL, 2008)
"Retching and vomiting responses increased with increasing morphine doses up to 1."3.71The cannabinoid agonist WIN55,212-2 suppresses opioid-induced emesis in ferrets. ( Hamza, MS; Makriyannis, A; Malan, TP; Mata, HP; Porreca, F; Siegel, EM; Simoneau, II; Vanderah, TW, 2001)
"Vomiting was assessed in shrews (Suncus murinus), pretreated with JZL184, a selective monoacylglycerol lipase (MAGL) inhibitor which elevates endogenous 2AG levels, 1 h before administering the emetogenic compound, LiCl."1.38Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats. ( Cravatt, BF; Limebeer, CL; Long, JZ; Mechoulam, R; Parker, LA; Rock, EM; Sticht, MA, 2012)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (80.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sticht, MA1
Long, JZ1
Rock, EM1
Limebeer, CL1
Mechoulam, R1
Cravatt, BF1
Parker, LA2
Cross-Mellor, SK1
Ossenkopp, KP1
Piomelli, D1
Sharkey, KA2
Cristino, L1
Oland, LD1
Van Sickle, MD1
Starowicz, K1
Pittman, QJ1
Guglielmotti, V1
Davison, JS1
Di Marzo, V1
Miller, MJ1
Reuter, BK1
Wallace, JL1
Simoneau, II1
Hamza, MS1
Mata, HP1
Siegel, EM1
Vanderah, TW1
Porreca, F1
Makriyannis, A1
Malan, TP1

Other Studies

5 other studies available for am 251 and Vomiting

ArticleYear
Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats.
    British journal of pharmacology, 2012, Volume: 165, Issue:8

    Topics: Animals; Arachidonic Acids; Behavior, Animal; Benzodioxoles; Brain; Endocannabinoids; Enzyme Inhibit

2012
Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat.
    Psychopharmacology, 2007, Volume: 190, Issue:2

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Association Learning; Avoidance Learning; Benzamides; C

2007
Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret.
    The European journal of neuroscience, 2007, Volume: 25, Issue:9

    Topics: Acrylamides; Animals; Antiemetics; Arachidonic Acids; Area Postrema; Autonomic Pathways; Brain Stem;

2007
A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient.
    Journal of translational medicine, 2008, Jan-18, Volume: 6

    Topics: Animals; Antiemetics; Antipruritics; Cell Line; Croton; Ferrets; Male; Mice; Mice, Inbred C57BL; Mor

2008
The cannabinoid agonist WIN55,212-2 suppresses opioid-induced emesis in ferrets.
    Anesthesiology, 2001, Volume: 94, Issue:5

    Topics: Analgesics, Opioid; Animals; Antiemetics; Benzoxazines; Ferrets; Male; Morphine; Morpholines; Naphth

2001