am 251 has been researched along with Tobacco Use Disorder in 5 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Tobacco Use Disorder: Tobacco used to the detriment of a person's health or social functioning. Tobacco dependence is included.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nicotine and the CS were only able to independently maintain responding to similar level under the [FI 10' (FR3: S)] schedule, which was subsequently employed to examine the effects of the selective CB1 receptor antagonist AM251." | 1.36 | Second-order schedules of nicotine reinforcement in rats: effect of AM251. ( Shoaib, M; Wing, VC, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wing, VC | 3 |
| Cagniard, B | 1 |
| Murphy, NP | 1 |
| Shoaib, M | 4 |
| Le Foll, B | 1 |
| Forget, B | 1 |
| Aubin, HJ | 1 |
| Goldberg, SR | 1 |
1 review available for am 251 and Tobacco Use Disorder
| Article | Year |
|---|---|
Blocking cannabinoid CB1 receptors for the treatment of nicotine dependence: insights from pre-clinical and clinical studies.
Topics: Animals; Brain; Cannabinoid Receptor Modulators; Clinical Trials as Topic; Drug Evaluation, Preclini | 2008 |
4 other studies available for am 251 and Tobacco Use Disorder
| Article | Year |
|---|---|
Measurement of affective state during chronic nicotine treatment and withdrawal by affective taste reactivity in mice: the role of endocannabinoids.
Topics: Affect; Animals; Avoidance Learning; Cannabinoid Receptor Modulators; Endocannabinoids; Male; Mice; | 2009 |
Second-order schedules of nicotine reinforcement in rats: effect of AM251.
Topics: Animals; Appetitive Behavior; Association Learning; Brain; Conditioning, Classical; Dopamine; Dose-R | 2010 |
A second-order schedule of food reinforcement in rats to examine the role of CB1 receptors in the reinforcement-enhancing effects of nicotine.
Topics: Animals; Appetitive Behavior; Association Learning; Brain; Conditioning, Classical; Dose-Response Re | 2010 |
The cannabinoid antagonist AM251 attenuates nicotine self-administration and nicotine-seeking behaviour in rats.
Topics: Animals; Cannabinoids; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Food; Male; Ni | 2008 |