am 251 has been researched along with Smoking Cessation in 3 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Smoking Cessation: Discontinuing the habit of SMOKING.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Data indicate the existence of a link between serotonergic and endocannabinoid systems in the mechanisms underlying mood disorders caused by nicotine abstinence and suggest that these interactions are potential targets for pharmacological aid in smoking cessation." | 7.77 | Interactions between endocannabinoid and serotonergic systems in mood disorders caused by nicotine withdrawal. ( Calapai, G; Caputi, AP; Mannucci, C; Navarra, M; Pieratti, A; Russo, GA, 2011) |
| "Data indicate the existence of a link between serotonergic and endocannabinoid systems in the mechanisms underlying mood disorders caused by nicotine abstinence and suggest that these interactions are potential targets for pharmacological aid in smoking cessation." | 3.77 | Interactions between endocannabinoid and serotonergic systems in mood disorders caused by nicotine withdrawal. ( Calapai, G; Caputi, AP; Mannucci, C; Navarra, M; Pieratti, A; Russo, GA, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bhatti, AS | 1 |
| Aydin, C | 1 |
| Oztan, O | 1 |
| Ma, Z | 1 |
| Hall, P | 1 |
| Tao, R | 1 |
| Isgor, C | 1 |
| Mannucci, C | 1 |
| Navarra, M | 1 |
| Pieratti, A | 1 |
| Russo, GA | 1 |
| Caputi, AP | 1 |
| Calapai, G | 1 |
| Le Foll, B | 1 |
| Forget, B | 1 |
| Aubin, HJ | 1 |
| Goldberg, SR | 1 |
1 review available for am 251 and Smoking Cessation
| Article | Year |
|---|---|
Blocking cannabinoid CB1 receptors for the treatment of nicotine dependence: insights from pre-clinical and clinical studies.
Topics: Animals; Brain; Cannabinoid Receptor Modulators; Clinical Trials as Topic; Drug Evaluation, Preclini | 2008 |
2 other studies available for am 251 and Smoking Cessation
| Article | Year |
|---|---|
Effects of a cannabinoid receptor (CB) 1 antagonist AM251 on behavioral sensitization to nicotine in a rat model of novelty-seeking behavior: correlation with hippocampal 5HT.
Topics: Animals; Behavior, Animal; Bupropion; Dose-Response Relationship, Drug; Exploratory Behavior; Hippoc | 2009 |
Interactions between endocannabinoid and serotonergic systems in mood disorders caused by nicotine withdrawal.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Modulators; Disease Models, Anima | 2011 |