Page last updated: 2024-10-22

am 251 and Sepsis

am 251 has been researched along with Sepsis in 3 studies

AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.

Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

Research Excerpts

ExcerptRelevanceReference
"A therapeutic option to treat sepsis is to promote intestinal propulsion preventing bacterial stasis, overgrowth and translocation."5.35Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase. ( d'amico, A; de Filippis, D; de Man, JG; de Winter, BY; Esposito, G; Herman, AG; Iuvone, T; Pelckmans, PA; Steardo, L, 2008)
"2-AG regulates vascular response to NA and increased aortic expression of CB1R is responsible for vascular hyporeactivity to NA in sepsis, and in vitro inhibition of this receptor by AM 251 restored the vascular reactivity."3.88Endocannabinoid-mediated modulation of Gq protein-coupled receptor mediates vascular hyporeactivity to nor-adrenaline during polymicrobial sepsis. ( Choudhury, S; Garg, SK; Gari, M; Nakade, UP; Sharma, A; Sharma, P; Shukla, A; Singh, P, 2018)
"A therapeutic option to treat sepsis is to promote intestinal propulsion preventing bacterial stasis, overgrowth and translocation."1.35Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase. ( d'amico, A; de Filippis, D; de Man, JG; de Winter, BY; Esposito, G; Herman, AG; Iuvone, T; Pelckmans, PA; Steardo, L, 2008)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Singh, P1
Sharma, P1
Nakade, UP1
Sharma, A1
Gari, M1
Choudhury, S1
Shukla, A1
Garg, SK1
Li, YY1
Li, YN1
Ni, JB1
Chen, CJ1
Lv, S1
Chai, SY1
Wu, RH1
YĆ¼ce, B1
Storr, M1
de Filippis, D1
Iuvone, T1
d'amico, A1
Esposito, G1
Steardo, L1
Herman, AG1
Pelckmans, PA1
de Winter, BY1
de Man, JG1

Other Studies

3 other studies available for am 251 and Sepsis

ArticleYear
Endocannabinoid-mediated modulation of Gq protein-coupled receptor mediates vascular hyporeactivity to nor-adrenaline during polymicrobial sepsis.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:6

    Topics: Animals; Aorta; Coinfection; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascul

2018
Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus.
    Neurogastroenterology and motility, 2010, Volume: 22, Issue:3

    Topics: Analysis of Variance; Animals; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Electroph

2010
Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase.
    Neurogastroenterology and motility, 2008, Volume: 20, Issue:8

    Topics: Amidohydrolases; Animals; Cannabidiol; Capsaicin; Gastric Emptying; Gastrointestinal Motility; Intes

2008