Page last updated: 2024-10-22

am 251 and Pregnancy

am 251 has been researched along with Pregnancy in 11 studies

AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"In agreement with the neurodevelopmental hypothesis of schizophrenia, prenatal exposure of rats to the antimitotic agent methylazoxymethanol acetate (MAM) at gestational day 17 produced long-lasting behavioral alterations such as social withdrawal and cognitive impairment in the social interaction test and in the novel object recognition test, respectively."7.91Peripubertal cannabidiol treatment rescues behavioral and neurochemical abnormalities in the MAM model of schizophrenia. ( Babinska, Z; Bari, M; D'Addario, C; Di Bartolomeo, M; Di Marco, R; Di Marzo, V; Drago, F; Drazanova, E; Giurdanella, G; Iannotti, FA; Maccarrone, M; Mechoulam, R; Micale, V; Pekarik, V; Piscitelli, F; Ruda-Kucerova, J; Salomone, S; Starcuk, Z; Stark, T; Sulcova, A; Wotjak, CT, 2019)
"In agreement with the neurodevelopmental hypothesis of schizophrenia, prenatal exposure of rats to the antimitotic agent methylazoxymethanol acetate (MAM) at gestational day 17 produced long-lasting behavioral alterations such as social withdrawal and cognitive impairment in the social interaction test and in the novel object recognition test, respectively."3.91Peripubertal cannabidiol treatment rescues behavioral and neurochemical abnormalities in the MAM model of schizophrenia. ( Babinska, Z; Bari, M; D'Addario, C; Di Bartolomeo, M; Di Marco, R; Di Marzo, V; Drago, F; Drazanova, E; Giurdanella, G; Iannotti, FA; Maccarrone, M; Mechoulam, R; Micale, V; Pekarik, V; Piscitelli, F; Ruda-Kucerova, J; Salomone, S; Starcuk, Z; Stark, T; Sulcova, A; Wotjak, CT, 2019)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's4 (36.36)29.6817
2010's6 (54.55)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Stark, T1
Ruda-Kucerova, J1
Iannotti, FA1
D'Addario, C1
Di Marco, R1
Pekarik, V1
Drazanova, E1
Piscitelli, F1
Bari, M1
Babinska, Z1
Giurdanella, G1
Di Bartolomeo, M1
Salomone, S1
Sulcova, A1
Maccarrone, M1
Wotjak, CT1
Starcuk, Z1
Drago, F1
Mechoulam, R1
Di Marzo, V2
Micale, V1
Kotlar, I1
Rangel-López, E1
Colonnello, A1
Aguilera-Portillo, G1
Serratos, IN1
Galván-Arzate, S1
Pedraza-Chaverri, J1
Túnez, I1
Wajner, M1
Santamaría, A1
Tree, KC1
Scotto di Perretolo, M1
Peyronnet, J1
Cayetanot, F1
Ramírez-López, MT1
Arco, R1
Decara, J1
Vázquez, M1
Noemí Blanco, R1
Alén, F1
Suárez, J1
Gómez de Heras, R1
Rodríguez de Fonseca, F1
Amico, JA1
Miedlar, JA1
Cai, HM1
Vollmer, RR1
Fonseca, BM1
Correia-da-Silva, G1
Teixeira, NA1
Tebano, MT1
Martire, A1
Chiodi, V1
Pepponi, R1
Ferrante, A1
Domenici, MR1
Frank, C1
Chen, JF1
Ledent, C1
Popoli, P1
Weems, YS1
Lewis, AW1
Neuendorff, DA1
Randel, RD1
Weems, CW1
D'Asti, E1
Long, H2
Tremblay-Mercier, J1
Grajzer, M1
Cunnane, SC1
Walker, CD2
Buwembo, A1
Paria, BC1
Ma, W1
Andrenyak, DM1
Schmid, PC1
Schmid, HH1
Moody, DE1
Deng, H1
Makriyannis, A1
Dey, SK1

Other Studies

11 other studies available for am 251 and Pregnancy

ArticleYear
Peripubertal cannabidiol treatment rescues behavioral and neurochemical abnormalities in the MAM model of schizophrenia.
    Neuropharmacology, 2019, 03-01, Volume: 146

    Topics: Amides; Animals; Arachidonic Acids; Cannabidiol; Disease Models, Animal; Endocannabinoids; Ethanolam

2019
Anandamide Reduces the Toxic Synergism Exerted by Quinolinic Acid and Glutaric Acid in Rat Brain Neuronal Cells.
    Neuroscience, 2019, 03-01, Volume: 401

    Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Cell Survival; Ce

2019
In utero cannabinoid exposure alters breathing and the response to hypoxia in newborn mice.
    The European journal of neuroscience, 2014, Volume: 40, Issue:1

    Topics: Animals; Animals, Newborn; Apnea; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor

2014
Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring.
    PloS one, 2016, Volume: 11, Issue:11

    Topics: Adipose Tissue; Animals; Animals, Newborn; Brain; Diet, High-Fat; Endocannabinoids; Female; Gene Exp

2016
Oxytocin knockout mice: a model for studying stress-related and ingestive behaviours.
    Progress in brain research, 2008, Volume: 170

    Topics: Animals; Body Temperature; Corticosterone; Crosses, Genetic; Environment; Feeding Behavior; Female;

2008
Anandamide-induced cell death: dual effects in primary rat decidual cell cultures.
    Placenta, 2009, Volume: 30, Issue:8

    Topics: Animals; Apoptosis; Arachidonic Acids; beta-Cyclodextrins; Cannabinoid Receptor Modulators; Cell Dea

2009
Adenosine A2A receptors enable the synaptic effects of cannabinoid CB1 receptors in the rodent striatum.
    Journal of neurochemistry, 2009, Volume: 110, Issue:6

    Topics: Action Potentials; Animals; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Cerebral Co

2009
Endocannabinoid 1 and 2 (CB(1); CB(2)) receptor agonists affect negatively cow luteal function in vitro.
    Prostaglandins & other lipid mediators, 2009, Volume: 90, Issue:3-4

    Topics: Adenine; Adenosine; Animals; Arachidonic Acids; Cattle; Corpus Luteum; Dinoprost; Dinoprostone; Fema

2009
Maternal dietary fat determines metabolic profile and the magnitude of endocannabinoid inhibition of the stress response in neonatal rat offspring.
    Endocrinology, 2010, Volume: 151, Issue:4

    Topics: Adipose Tissue; Adrenocorticotropic Hormone; Analysis of Variance; Animals; Animals, Suckling; Body

2010
Participation of endocannabinoids in rapid suppression of stress responses by glucocorticoids in neonates.
    Neuroscience, 2013, Sep-26, Volume: 249

    Topics: Animals; Animals, Newborn; Endocannabinoids; Female; Glucocorticoids; Male; Piperidines; Pregnancy;

2013
Effects of cannabinoids on preimplantation mouse embryo development and implantation are mediated by brain-type cannabinoid receptors.
    Biology of reproduction, 1998, Volume: 58, Issue:6

    Topics: Animals; Arachidonic Acids; Brain; Cannabinoids; Cytochrome P-450 Enzyme Inhibitors; Dronabinol; Emb

1998