Page last updated: 2024-10-22
am 251 and Nausea
am 251 has been researched along with Nausea in 8 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The cannabinoid 1 (CB1 ) receptor inverse agonists/antagonists, rimonabant (SR141716, SR) and AM251, produce nausea and potentiate toxin-induced nausea by inverse agonism (rather than antagonism) of the CB1 receptor." | 7.79 | Evaluation of the potential of the phytocannabinoids, cannabidivarin (CBDV) and Δ(9) -tetrahydrocannabivarin (THCV), to produce CB1 receptor inverse agonism symptoms of nausea in rats. ( Duncan, M; Parker, LA; Rock, EM; Sticht, MA; Stott, C, 2013) |
| "The results suggest that prolonging the action of anandamide by pretreatment with the FAAH inhibitor, URB597, suppresses lithium-induced nausea in the rat." | 7.74 | Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat. ( Cross-Mellor, SK; Ossenkopp, KP; Parker, LA; Piomelli, D, 2007) |
| "Emesis was induced in ferrets with morphine-6-glucuronide (0." | 7.74 | A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient. ( Miller, MJ; Reuter, BK; Sharkey, KA; Wallace, JL, 2008) |
| "Considering the known antiemetic and motor-suppressive effects of CB1 agonists, the present studies were conducted to determine if the reductions in food intake induced by the CB1 antagonist AM 251 could result from nausea or impairments in intake-related motor control, rather than solely from appetite suppression." | 7.73 | The cannabinoid CB1 antagonist AM 251 produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats. ( Limebeer, CL; Makriyannis, A; McLaughlin, PJ; Parker, LA; Salamone, JD; Winston, KM, 2005) |
| "The cannabinoid 1 (CB1 ) receptor inverse agonists/antagonists, rimonabant (SR141716, SR) and AM251, produce nausea and potentiate toxin-induced nausea by inverse agonism (rather than antagonism) of the CB1 receptor." | 3.79 | Evaluation of the potential of the phytocannabinoids, cannabidivarin (CBDV) and Δ(9) -tetrahydrocannabivarin (THCV), to produce CB1 receptor inverse agonism symptoms of nausea in rats. ( Duncan, M; Parker, LA; Rock, EM; Sticht, MA; Stott, C, 2013) |
| "The conditioned gaping model of nausea in rats was used to compare the CB(1) receptor antagonist/inverse agonist, AM251, and the CB(1) receptor neutral antagonists, AM6527 (centrally and peripherally active) and AM6545 (peripherally active), in potentiating conditioned gaping produced by lithium chloride (LiCl) solution." | 3.76 | Inverse agonism of cannabinoid CB1 receptors potentiates LiCl-induced nausea in the conditioned gaping model in rats. ( Bedard, H; Lang, ST; Limebeer, CL; Makriyannis, A; Ossenkopp, KP; Parker, LA; Vemuri, VK, 2010) |
| "The results suggest that prolonging the action of anandamide by pretreatment with the FAAH inhibitor, URB597, suppresses lithium-induced nausea in the rat." | 3.74 | Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat. ( Cross-Mellor, SK; Ossenkopp, KP; Parker, LA; Piomelli, D, 2007) |
| "Emesis was induced in ferrets with morphine-6-glucuronide (0." | 3.74 | A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient. ( Miller, MJ; Reuter, BK; Sharkey, KA; Wallace, JL, 2008) |
| "Considering the known antiemetic and motor-suppressive effects of CB1 agonists, the present studies were conducted to determine if the reductions in food intake induced by the CB1 antagonist AM 251 could result from nausea or impairments in intake-related motor control, rather than solely from appetite suppression." | 3.73 | The cannabinoid CB1 antagonist AM 251 produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats. ( Limebeer, CL; Makriyannis, A; McLaughlin, PJ; Parker, LA; Salamone, JD; Winston, KM, 2005) |
| "Vomiting was assessed in shrews (Suncus murinus), pretreated with JZL184, a selective monoacylglycerol lipase (MAGL) inhibitor which elevates endogenous 2AG levels, 1 h before administering the emetogenic compound, LiCl." | 1.38 | Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats. ( Cravatt, BF; Limebeer, CL; Long, JZ; Mechoulam, R; Parker, LA; Rock, EM; Sticht, MA, 2012) |
Research
Studies (8)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Rock, EM | 3 |
| Sticht, MA | 2 |
| Duncan, M | 1 |
| Stott, C | 1 |
| Parker, LA | 7 |
| Limebeer, CL | 4 |
| Vemuri, VK | 2 |
| Bedard, H | 1 |
| Lang, ST | 1 |
| Ossenkopp, KP | 2 |
| Makriyannis, A | 3 |
| Long, JZ | 1 |
| Mechoulam, R | 2 |
| Cravatt, BF | 1 |
| McLaughlin, PJ | 2 |
| Winston, KM | 1 |
| Salamone, JD | 2 |
| Cross-Mellor, SK | 1 |
| Piomelli, D | 1 |
| Sink, KS | 1 |
| Wood, JA | 1 |
| Brown, C | 1 |
| Fan, P | 1 |
| Peng, Y | 1 |
| Pang, Y | 1 |
| Olszewska, T | 1 |
| Olzewska, T | 1 |
| Thakur, GA | 1 |
| Miller, MJ | 1 |
| Reuter, BK | 1 |
| Wallace, JL | 1 |
| Sharkey, KA | 1 |
Other Studies
8 other studies available for am 251 and Nausea
| Article | Year |
|---|---|
Evaluation of the potential of the phytocannabinoids, cannabidivarin (CBDV) and Δ(9) -tetrahydrocannabivarin (THCV), to produce CB1 receptor inverse agonism symptoms of nausea in rats.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Cannabinoids; Disease Models, Animal; Dron | 2013 |
Inverse agonism of cannabinoid CB1 receptors potentiates LiCl-induced nausea in the conditioned gaping model in rats.
Topics: Administration, Oral; Animals; Brain; Conditioning, Classical; Disease Models, Animal; Dose-Response | 2010 |
Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Benzodioxoles; Brain; Endocannabinoids; Enzyme Inhibit | 2012 |
The anti-nausea effects of CB1 agonists are mediated by an action at the visceral insular cortex.
Topics: Animals; Antiemetics; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cerebral Cort | 2012 |
The cannabinoid CB1 antagonist AM 251 produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats.
Topics: Animals; Appetite Depressants; Avoidance Learning; Conditioning, Psychological; Dose-Response Relati | 2005 |
Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Association Learning; Avoidance Learning; Benzamides; C | 2007 |
The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats.
Topics: Adamantane; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Cyclic AMP; Dose | 2008 |
A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient.
Topics: Animals; Antiemetics; Antipruritics; Cell Line; Croton; Ferrets; Male; Mice; Mice, Inbred C57BL; Mor | 2008 |