am 251 has been researched along with Melanoma in 2 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human cutaneous melanoma is an aggressive and chemotherapy-resistant type of cancer." | 1.42 | AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells. ( Adinolfi, B; Breschi, MC; Carpi, S; Costa, B; Da Pozzo, E; Fogli, S; Martini, C; Nieri, P; Pellegrino, M; Podestà, A; Romanini, A, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carpi, S | 1 |
| Fogli, S | 1 |
| Romanini, A | 1 |
| Pellegrino, M | 1 |
| Adinolfi, B | 1 |
| Podestà, A | 1 |
| Costa, B | 1 |
| Da Pozzo, E | 1 |
| Martini, C | 1 |
| Breschi, MC | 1 |
| Nieri, P | 1 |
| Kenessey, I | 1 |
| Bánki, B | 1 |
| Márk, A | 1 |
| Varga, N | 1 |
| Tóvári, J | 1 |
| Ladányi, A | 1 |
| Rásó, E | 1 |
| Tímár, J | 1 |
2 other studies available for am 251 and Melanoma
| Article | Year |
|---|---|
AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells.
Topics: Antineoplastic Agents; Apoptosis; Calcium Channels; Celecoxib; Cell Line, Tumor; Cell Survival; Cycl | 2015 |
Revisiting CB1 receptor as drug target in human melanoma.
Topics: Animals; Apoptosis; Arachidonic Acids; Base Sequence; Cannabinoids; Cell Line, Tumor; Cell Movement; | 2012 |