am 251 has been researched along with Inflammation in 20 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spinal glial activation has been implicated in sustained morphine-mediated paradoxical pain sensitization." | 7.78 | Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist. ( Keresztes, A; Largent-Milnes, TM; Ren, J; Roeske, WR; Tumati, S; Vanderah, TW; Varga, EV, 2012) |
| "The pharmacological inhibition of anandamide (AEA) hydrolysis by fatty acid amide hydrolase (FAAH) attenuates pain in animal models of osteoarthritis (OA) but has failed in clinical trials." | 3.81 | A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis. ( Binkowski, M; Czaja, M; Di Marzo, V; Kolosowska, N; Makuch, W; Malek, N; Morera, E; Mrugala, M; Przewlocka, B; Starowicz, K, 2015) |
| "Spinal glial activation has been implicated in sustained morphine-mediated paradoxical pain sensitization." | 3.78 | Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist. ( Keresztes, A; Largent-Milnes, TM; Ren, J; Roeske, WR; Tumati, S; Vanderah, TW; Varga, EV, 2012) |
| "In this study we analyzed the mechanisms underlying celecoxib-induced analgesia in a model of inflammatory pain in rats, using the intracerebroventricular (i." | 3.78 | Endogenous opioid and cannabinoid mechanisms are involved in the analgesic effects of celecoxib in the central nervous system. ( Bakhle, YS; Camêlo, VM; Dos Reis, WG; Faraco, A; Francischi, JN; Paiva-Lima, P; Rezende, RM, 2012) |
| "Cannabinoids, such as anandamide, are involved in pain transmission." | 3.74 | AM404 decreases Fos-immunoreactivity in the spinal cord in a model of inflammatory pain. ( Bianchi, R; Borsani, E; Labanca, M; Rodella, LF, 2007) |
| "Obesity is characterized by chronic low-grade inflammation that contributes to development of cardiometabolic disorders." | 1.51 | Cannabinoid Receptor 1 Blockade Attenuates Obesity and Adipose Tissue Type 1 Inflammation Through miR-30e-5p Regulation of Delta-Like-4 in Macrophages and Consequently Downregulation of Th1 Cells. ( Mehrpouya-Bahrami, P; Miranda, K; Nagarkatti, M; Nagarkatti, PS, 2019) |
| "The results showed that JZL lowered brain infarction, neurological disorders, TNF-α and MMP9 more effectively than JZL plus AM251." | 1.48 | JZL184, as a monoacylglycerol lipase inhibitor, down-regulates inflammation in a cannabinoid pathway dependent manner. ( Allahtavakoli, M; Bazmandegan, G; Moghadam-Ahmadi, A; Rahmani, MR; Shamsizadeh, A, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 13 (65.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rodrigues, FF | 1 |
| Morais, MI | 1 |
| Melo, ISF | 1 |
| Augusto, PSA | 1 |
| Dutra, MMGB | 1 |
| Costa, SOAM | 1 |
| Costa, FC | 1 |
| Goulart, FA | 1 |
| Braga, AV | 1 |
| Coelho, MM | 1 |
| Machado, RR | 1 |
| Zhang, D | 1 |
| Liu, X | 1 |
| Dong, X | 1 |
| Zhu, R | 1 |
| Jiang, J | 1 |
| Ye, Y | 1 |
| Jiang, Y | 1 |
| Rahmani, MR | 1 |
| Shamsizadeh, A | 1 |
| Moghadam-Ahmadi, A | 1 |
| Bazmandegan, G | 1 |
| Allahtavakoli, M | 1 |
| Miranda, K | 1 |
| Mehrpouya-Bahrami, P | 1 |
| Nagarkatti, PS | 1 |
| Nagarkatti, M | 1 |
| Prestifilippo, JP | 1 |
| Medina, VA | 1 |
| Mohn, CE | 1 |
| Rodriguez, PA | 1 |
| Elverdin, JC | 1 |
| Fernandez-Solari, J | 1 |
| Petrenko, AB | 1 |
| Yamazaki, M | 1 |
| Sakimura, K | 1 |
| Kano, M | 1 |
| Baba, H | 1 |
| Krustev, E | 1 |
| Reid, A | 1 |
| McDougall, JJ | 1 |
| Malek, N | 1 |
| Mrugala, M | 1 |
| Makuch, W | 1 |
| Kolosowska, N | 1 |
| Przewlocka, B | 1 |
| Binkowski, M | 1 |
| Czaja, M | 1 |
| Morera, E | 1 |
| Di Marzo, V | 1 |
| Starowicz, K | 1 |
| Carey, LM | 1 |
| Slivicki, RA | 1 |
| Leishman, E | 1 |
| Cornett, B | 1 |
| Mackie, K | 1 |
| Bradshaw, H | 1 |
| Hohmann, AG | 1 |
| Sagar, DR | 1 |
| Kendall, DA | 1 |
| Chapman, V | 1 |
| Potenzieri, C | 1 |
| Brink, TS | 1 |
| Pacharinsak, C | 1 |
| Simone, DA | 1 |
| Lin, XH | 1 |
| Yuece, B | 1 |
| Li, YY | 1 |
| Feng, YJ | 1 |
| Feng, JY | 1 |
| Yu, LY | 1 |
| Li, K | 1 |
| Li, YN | 1 |
| Storr, M | 1 |
| Alhamoruni, A | 1 |
| Wright, KL | 1 |
| Larvin, M | 1 |
| O'Sullivan, SE | 1 |
| Ebrahimzadeh, M | 1 |
| Haghparast, A | 1 |
| Tumati, S | 1 |
| Largent-Milnes, TM | 1 |
| Keresztes, A | 1 |
| Ren, J | 1 |
| Roeske, WR | 1 |
| Vanderah, TW | 1 |
| Varga, EV | 1 |
| Escobar, W | 1 |
| Ramirez, K | 1 |
| Avila, C | 1 |
| Limongi, R | 1 |
| Vanegas, H | 1 |
| Vazquez, E | 1 |
| Rezende, RM | 1 |
| Paiva-Lima, P | 1 |
| Dos Reis, WG | 1 |
| Camêlo, VM | 1 |
| Faraco, A | 1 |
| Bakhle, YS | 1 |
| Francischi, JN | 1 |
| Guindon, J | 1 |
| De Léan, A | 1 |
| Beaulieu, P | 1 |
| Borsani, E | 1 |
| Labanca, M | 1 |
| Bianchi, R | 1 |
| Rodella, LF | 1 |
| Mitchell, VA | 1 |
| Greenwood, R | 1 |
| Jayamanne, A | 1 |
| Vaughan, CW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Osteoarthritis of the Knee Pain Study Using CBD and THC in Rapidly Dissolvable Sublingual Tablet[NCT04195269] | Phase 2 | 30 participants (Anticipated) | Interventional | 2020-04-20 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
20 other studies available for am 251 and Inflammation
| Article | Year |
|---|---|
Clindamycin inhibits nociceptive response by reducing tumor necrosis factor-α and CXCL-1 production and activating opioidergic mechanisms.
Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; | 2020 |
Cannabinoid 1 Receptor Antagonists Play a Neuroprotective Role in Chronic Alcoholic Hippocampal Injury Related to Pyroptosis Pathway.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Cannabinoid Receptor Agonists; Cannabinoid Recep | 2020 |
JZL184, as a monoacylglycerol lipase inhibitor, down-regulates inflammation in a cannabinoid pathway dependent manner.
Topics: Animals; Benzodioxoles; Brain Edema; Brain Infarction; Cannabinoids; Down-Regulation; Enzyme Inhibit | 2018 |
Cannabinoid Receptor 1 Blockade Attenuates Obesity and Adipose Tissue Type 1 Inflammation Through miR-30e-5p Regulation of Delta-Like-4 in Macrophages and Consequently Downregulation of Th1 Cells.
Topics: Adaptor Proteins, Signal Transducing; Adipose Tissue; Animals; Calcium-Binding Proteins; Diet, High- | 2019 |
Endocannabinoids mediate hyposalivation induced by inflammogens in the submandibular glands and hypothalamus.
Topics: Analysis of Variance; Animals; Cannabinoid Receptor Agonists; Dinoprostone; Endocannabinoids; Hypoth | 2013 |
Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol.
Topics: Animals; Arachidonic Acids; Benzodioxoles; Cannabinoid Receptor Modulators; Endocannabinoids; Glycer | 2014 |
Tapping into the endocannabinoid system to ameliorate acute inflammatory flares and associated pain in mouse knee joints.
Topics: Acute Disease; Amidohydrolases; Animals; Arthralgia; Benzamides; Carbamates; Carrageenan; Endocannab | 2014 |
A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis.
Topics: Activating Transcription Factor 3; Amidohydrolases; Anilides; Animals; Arachidonic Acids; Benzamides | 2015 |
A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.
Topics: Acrylamides; Amidohydrolases; Analgesia; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heter | 2016 |
Inhibition of fatty acid amide hydrolase produces PPAR-alpha-mediated analgesia in a rat model of inflammatory pain.
Topics: Amidohydrolases; Analgesia; Animals; Benzamides; Carbamates; Carrageenan; Disease Models, Animal; In | 2008 |
Cannabinoid modulation of cutaneous Adelta nociceptors during inflammation.
Topics: Action Potentials; Analysis of Variance; Animals; Arachidonic Acids; Cannabinoids; Dose-Response Rel | 2008 |
A novel CB receptor GPR55 and its ligands are involved in regulation of gut movement in rodents.
Topics: Animals; Cannabidiol; Electromyography; Gastrointestinal Motility; Gastrointestinal Transit; Indoles | 2011 |
Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability.
Topics: Amidohydrolases; Benzamides; Benzodioxoles; Caco-2 Cells; Cannabinoids; Carbamates; Cell Survival; E | 2012 |
Analgesic effects of cannabinoid receptor agonist WIN55,212-2 in the nucleus cuneiformis in animal models of acute and inflammatory pain in rats.
Topics: Analgesics; Analysis of Variance; Animals; Area Under Curve; Benzoxazines; Cannabinoid Receptor Agon | 2011 |
Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist.
Topics: Analgesics; Analgesics, Opioid; Animals; Cannabinoids; Hyperalgesia; Indoles; Inflammation; Interleu | 2012 |
Metamizol, a non-opioid analgesic, acts via endocannabinoids in the PAG-RVM axis during inflammation in rats.
Topics: Action Potentials; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cannabinoid Receptor Modulators | 2012 |
Endogenous opioid and cannabinoid mechanisms are involved in the analgesic effects of celecoxib in the central nervous system.
Topics: Analgesics; Animals; Carrageenan; Celecoxib; Central Nervous System; Cyclooxygenase 2; Cyclooxygenas | 2012 |
Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain.
Topics: Acute Disease; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic A | 2006 |
AM404 decreases Fos-immunoreactivity in the spinal cord in a model of inflammatory pain.
Topics: Animals; Arachidonic Acids; Capsaicin; Endocannabinoids; Immunohistochemistry; Indoles; Inflammation | 2007 |
Actions of the endocannabinoid transport inhibitor AM404 in neuropathic and inflammatory pain models.
Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Carrier Proteins; Disease M | 2007 |