am 251 has been researched along with Hypothermia in 6 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The general aims of this study were to: 1) examine whether the limited antagonist activity of SR 141716A generalizes to the cannabinoid CB(1) antagonist N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM 251); and 2) examine mechanisms by which cannabinoids produce hypothermia, catalepsy, and hypoactivity in C57BL/6J mice." | 3.74 | Differences in the relative potency of SR 141716A and AM 251 as antagonists of various in vivo effects of cannabinoid agonists in C57BL/6J mice. ( Koek, W; McMahon, LR, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pryce, G | 2 |
| Baker, D | 2 |
| Vigolo, A | 1 |
| Ossato, A | 1 |
| Trapella, C | 1 |
| Vincenzi, F | 1 |
| Rimondo, C | 1 |
| Seri, C | 1 |
| Varani, K | 1 |
| Serpelloni, G | 1 |
| Marti, M | 1 |
| Ayoub, SS | 1 |
| Seed, MP | 1 |
| Bolton, C | 1 |
| Flower, RJ | 1 |
| Järbe, TU | 1 |
| Tai, S | 1 |
| LeMay, BJ | 1 |
| Nikas, SP | 1 |
| Shukla, VG | 1 |
| Zvonok, A | 1 |
| Makriyannis, A | 1 |
| Suzuki, N | 1 |
| Suzuki, M | 1 |
| Hamajo, K | 1 |
| Murakami, K | 1 |
| Tsukamoto, T | 1 |
| Shimojo, M | 1 |
| McMahon, LR | 1 |
| Koek, W | 1 |
6 other studies available for am 251 and Hypothermia
| Article | Year |
|---|---|
Antidote to cannabinoid intoxication: the CB
Topics: Animals; Antidotes; Cannabinoid Receptor Agonists; Drug Inverse Agonism; Female; Hypothermia; Mice; | 2017 |
Novel halogenated derivates of JWH-018: Behavioral and binding studies in mice.
Topics: Animals; Binding, Competitive; Cannabinoid Receptor Agonists; Cannabinoids; Catalepsy; CHO Cells; Cr | 2015 |
Paracetamol-induced hypothermia is independent of cannabinoids and transient receptor potential vanilloid-1 and is not mediated by AM404.
Topics: Acetaminophen; Amidohydrolases; Anilides; Animals; Arachidonic Acids; Cannabinoids; Cinnamates; Hypo | 2011 |
AM2389, a high-affinity, in vivo potent CB1-receptor-selective cannabinergic ligand as evidenced by drug discrimination in rats and hypothermia testing in mice.
Topics: Animals; Benzopyrans; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationsh | 2012 |
Contribution of hypothermia and CB1 receptor activation to protective effects of TAK-937, a cannabinoid receptor agonist, in rat transient MCAO model.
Topics: Amides; Animals; Benzofurans; Body Temperature; Disease Models, Animal; Hypothermia; Infarction, Mid | 2012 |
Differences in the relative potency of SR 141716A and AM 251 as antagonists of various in vivo effects of cannabinoid agonists in C57BL/6J mice.
Topics: Animals; Benzoxazines; Cannabinoids; Catalepsy; Dose-Response Relationship, Drug; Dronabinol; Hypoth | 2007 |