am 251 has been researched along with Hypotension in 3 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When SR141716A or AM251 was administered, the MAP response to NE was (41." | 1.35 | CB1 cannabinoid receptor participates in the vascular hyporeactivity resulting from hemorrhagic shock in rats. ( Hou, LC; Ji, GL; Li, N; Lu, Y; Wang, YM; Xie, KL; Xiong, LZ; Zheng, LN, 2009) |
| "Anandamide was able to inhibit dural blood vessel dilation brought about by electrical stimulation by 50%, calcitonin gene-related peptide (CGRP) by 30%, capsaicin by 45%, and nitric oxide by 40%." | 1.32 | Anandamide is able to inhibit trigeminal neurons using an in vivo model of trigeminovascular-mediated nociception. ( Akerman, S; Goadsby, PJ; Kaube, H, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hou, LC | 1 |
| Li, N | 1 |
| Zheng, LN | 1 |
| Lu, Y | 1 |
| Xie, KL | 1 |
| Wang, YM | 1 |
| Ji, GL | 1 |
| Xiong, LZ | 1 |
| Akerman, S | 1 |
| Kaube, H | 1 |
| Goadsby, PJ | 1 |
| Bátkai, S | 1 |
| Pacher, P | 1 |
| Járai, Z | 1 |
| Wagner, JA | 1 |
| Kunos, G | 1 |
3 other studies available for am 251 and Hypotension
| Article | Year |
|---|---|
CB1 cannabinoid receptor participates in the vascular hyporeactivity resulting from hemorrhagic shock in rats.
Topics: Animals; Blotting, Western; Gene Expression Regulation; Hypotension; Male; Piperidines; Pyrazoles; R | 2009 |
Anandamide is able to inhibit trigeminal neurons using an in vivo model of trigeminovascular-mediated nociception.
Topics: Animals; Arachidonic Acids; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Electric Sti | 2004 |
Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors.
Topics: Animals; Cannabinoids; Endotoxins; Heart; Heart Rate; Hemodynamics; Hypotension; Male; Mice; Mice, K | 2004 |