am 251 has been researched along with Hypertension in 9 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results broadly support the literature showing that the cardiovascular effects of cannabinoids can be exaggerated in hypertension, but highlight the involvement of non-CB(1) receptor-mediated mechanisms in the actions of anandamide." | 3.75 | Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats. ( Gardiner, SM; Ho, WS, 2009) |
| "We conclude that endocannabinoids tonically suppress cardiac contractility in hypertension and that enhancing the CB1-mediated cardiodepressor and vasodilator effects of endogenous anandamide by blocking its hydrolysis can normalize blood pressure." | 3.72 | Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. ( Bátkai, S; Bukoski, RD; Harvey-White, J; Kunos, G; Liu, J; Mackie, K; Offertáler, L; Osei-Hyiaman, D; Pacher, P; Radaeva, S; Rudd, MA, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, GQ | 2 |
| Wang, Z | 1 |
| Zhao, T | 1 |
| Dai, SX | 1 |
| Liu, JM | 1 |
| Jia, BZ | 1 |
| Zhang, Y | 2 |
| Li, Q | 2 |
| Wang, T | 1 |
| Zhang, HP | 1 |
| Ho, WS | 1 |
| Gardiner, SM | 4 |
| Szekeres, M | 1 |
| Nádasy, GL | 1 |
| Turu, G | 1 |
| Soltész-Katona, E | 1 |
| Tóth, ZE | 1 |
| Balla, A | 1 |
| Catt, KJ | 1 |
| Hunyady, L | 1 |
| Iring, A | 1 |
| Ruisanchez, É | 1 |
| Leszl-Ishiguro, M | 1 |
| Horváth, B | 1 |
| Benkő, R | 1 |
| Lacza, Z | 1 |
| Járai, Z | 1 |
| Sándor, P | 1 |
| Di Marzo, V | 1 |
| Pacher, P | 2 |
| Benyó, Z | 1 |
| Bátkai, S | 1 |
| Osei-Hyiaman, D | 1 |
| Radaeva, S | 1 |
| Liu, J | 1 |
| Harvey-White, J | 1 |
| Offertáler, L | 1 |
| Mackie, K | 1 |
| Rudd, MA | 1 |
| Bukoski, RD | 1 |
| Kunos, G | 1 |
| Wheal, AJ | 2 |
| Bennett, T | 2 |
| Randall, MD | 3 |
| O'Sullivan, SE | 1 |
9 other studies available for am 251 and Hypertension
| Article | Year |
|---|---|
Role of cannabinoid receptor type 1 in rostral ventrolateral medulla in high-fat diet-induced hypertension in rats.
Topics: Animals; Blood Pressure; Diet, High-Fat; Endocannabinoids; Gene Silencing; Heart Rate; Hypertension; | 2018 |
Overactivation of cannabinoid receptor type 1 in rostral ventrolateral medulla promotes cardiovascular responses in spontaneously hypertensive rats.
Topics: Animals; Arachidonic Acids; beta-Arrestin 2; Blood Pressure; Essential Hypertension; Heart Rate; Hyp | 2017 |
Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats.
Topics: Acute Disease; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Blood Pressure | 2009 |
Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors.
Topics: Analgesics; Angiotensin II; Animals; Arteries; Benzoxazines; Endocannabinoids; Endothelium, Vascular | 2012 |
Role of endocannabinoids and cannabinoid-1 receptors in cerebrocortical blood flow regulation.
Topics: Animals; Arachidonic Acids; Arterial Pressure; Cerebrovascular Circulation; Endocannabinoids; Heart | 2013 |
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension.
Topics: Amidohydrolases; Angiotensin II; Animals; Arachidonic Acids; Benzamides; Benzyl Compounds; Blood Pre | 2004 |
Effects of chronic nitric oxide synthase inhibition on the cardiovascular responses to cannabinoids in vivo and in vitro.
Topics: Animals; Arachidonic Acids; Benzoxazines; Blood Pressure; Cannabinoids; Disease Models, Animal; Dose | 2007 |
The in vitro and in vivo cardiovascular effects of Delta9-tetrahydrocannabinol in rats made hypertensive by chronic inhibition of nitric-oxide synthase.
Topics: Animals; Blood Pressure; Dronabinol; Enzyme Inhibitors; Heart Rate; Hypertension; Male; NG-Nitroargi | 2007 |
Cardiovascular effects of cannabinoids in conscious spontaneously hypertensive rats.
Topics: Animals; Arachidonic Acids; Benzoxazines; Blood Pressure; Cannabinoids; Cardiovascular System; Consc | 2007 |