Page last updated: 2024-10-22

am 251 and Hyperphagia

am 251 has been researched along with Hyperphagia in 7 studies

AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.

Hyperphagia: Ingestion of a greater than optimal quantity of food.

Research Excerpts

ExcerptRelevanceReference
"3, 1, and 3 mg/kg) enhanced cumulative food intake during the first 12 h with a dome-shaped dose-response relationship in freely fed rats, with the most effective dose being 1 mg/kg."1.42Differential modulation of endogenous cannabinoid CB1 and CB2 receptors in spontaneous and splice variants of ghrelin-induced food intake in conscious rats. ( Chen, CY; Chi, CW; Li, CP; Ting, CH, 2015)
"Hemopressin is a short, nine amino acid peptide (H-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH) isolated from rat brain that behaves as an inverse agonist at the cannabinoid receptor CB(1), and is shown here to inhibit agonist-induced receptor internalization in a heterologous cell model."1.36The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice. ( Dodd, GT; Luckman, SM; Lutz, B; Mancini, G, 2010)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's5 (71.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Soria-Gómez, E2
Massa, F1
Bellocchio, L1
Rueda-Orozco, PE1
Ciofi, P1
Cota, D1
Oliet, SH1
Prospéro-García, O2
Marsicano, G1
Ting, CH1
Chi, CW1
Li, CP1
Chen, CY1
Judge, MK1
Zhang, Y1
Scarpace, PJ1
Dodd, GT1
Mancini, G1
Lutz, B1
Luckman, SM1
Márquez-Diosdado, MI1
Montes-Rodríguez, CJ1
Estrada-González, V1
Deshmukh, RR1
Sharma, PL1
Ho, J1
Cox, JM1
Wagner, EJ1

Other Studies

7 other studies available for am 251 and Hyperphagia

ArticleYear
Cannabinoid type-1 receptors in the paraventricular nucleus of the hypothalamus inhibit stimulated food intake.
    Neuroscience, 2014, Mar-28, Volume: 263

    Topics: Animals; Cannabinoid Receptor Antagonists; Ghrelin; Hyperphagia; Male; Membrane Potentials; Neurons;

2014
Differential modulation of endogenous cannabinoid CB1 and CB2 receptors in spontaneous and splice variants of ghrelin-induced food intake in conscious rats.
    Nutrition (Burbank, Los Angeles County, Calif.), 2015, Volume: 31, Issue:1

    Topics: Animals; Eating; Endocannabinoids; Fasting; Ghrelin; Hyperphagia; Indoles; Male; Piperidines; Pyrazo

2015
Responses to the cannabinoid receptor-1 antagonist, AM251, are more robust with age and with high-fat feeding.
    The Journal of endocrinology, 2009, Volume: 203, Issue:2

    Topics: Age Factors; Animals; Appetite Depressants; Body Composition; Dietary Fats; Energy Intake; Hyperphag

2009
The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, May-26, Volume: 30, Issue:21

    Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Chlorocebus aethiops; Circadian Rhyth

2010
Oleamide administered into the nucleus accumbens shell regulates feeding behaviour via CB1 and 5-HT2C receptors.
    The international journal of neuropsychopharmacology, 2010, Volume: 13, Issue:9

    Topics: Aminopyridines; Animals; Eating; Feeding Behavior; Hyperphagia; Hypothalamus; Indoles; Ketanserin; M

2010
Stimulation of accumbens shell cannabinoid CB(1) receptors by noladin ether, a putative endocannabinoid, modulates food intake and dietary selection in rats.
    Pharmacological research, 2012, Volume: 66, Issue:3

    Topics: Animals; Appetite; Arachidonic Acids; Cannabinoid Receptor Modulators; Diet; Diet, High-Fat; Dietary

2012
Cannabinoid-induced hyperphagia: correlation with inhibition of proopiomelanocortin neurons?
    Physiology & behavior, 2007, Oct-22, Volume: 92, Issue:3

    Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Body Weight; Cannabinoids

2007