am 251 has been researched along with Hyperphagia in 7 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Hyperphagia: Ingestion of a greater than optimal quantity of food.
| Excerpt | Relevance | Reference |
|---|---|---|
| "3, 1, and 3 mg/kg) enhanced cumulative food intake during the first 12 h with a dome-shaped dose-response relationship in freely fed rats, with the most effective dose being 1 mg/kg." | 1.42 | Differential modulation of endogenous cannabinoid CB1 and CB2 receptors in spontaneous and splice variants of ghrelin-induced food intake in conscious rats. ( Chen, CY; Chi, CW; Li, CP; Ting, CH, 2015) |
| "Hemopressin is a short, nine amino acid peptide (H-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH) isolated from rat brain that behaves as an inverse agonist at the cannabinoid receptor CB(1), and is shown here to inhibit agonist-induced receptor internalization in a heterologous cell model." | 1.36 | The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice. ( Dodd, GT; Luckman, SM; Lutz, B; Mancini, G, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Soria-Gómez, E | 2 |
| Massa, F | 1 |
| Bellocchio, L | 1 |
| Rueda-Orozco, PE | 1 |
| Ciofi, P | 1 |
| Cota, D | 1 |
| Oliet, SH | 1 |
| Prospéro-García, O | 2 |
| Marsicano, G | 1 |
| Ting, CH | 1 |
| Chi, CW | 1 |
| Li, CP | 1 |
| Chen, CY | 1 |
| Judge, MK | 1 |
| Zhang, Y | 1 |
| Scarpace, PJ | 1 |
| Dodd, GT | 1 |
| Mancini, G | 1 |
| Lutz, B | 1 |
| Luckman, SM | 1 |
| Márquez-Diosdado, MI | 1 |
| Montes-Rodríguez, CJ | 1 |
| Estrada-González, V | 1 |
| Deshmukh, RR | 1 |
| Sharma, PL | 1 |
| Ho, J | 1 |
| Cox, JM | 1 |
| Wagner, EJ | 1 |
7 other studies available for am 251 and Hyperphagia
| Article | Year |
|---|---|
Cannabinoid type-1 receptors in the paraventricular nucleus of the hypothalamus inhibit stimulated food intake.
Topics: Animals; Cannabinoid Receptor Antagonists; Ghrelin; Hyperphagia; Male; Membrane Potentials; Neurons; | 2014 |
Differential modulation of endogenous cannabinoid CB1 and CB2 receptors in spontaneous and splice variants of ghrelin-induced food intake in conscious rats.
Topics: Animals; Eating; Endocannabinoids; Fasting; Ghrelin; Hyperphagia; Indoles; Male; Piperidines; Pyrazo | 2015 |
Responses to the cannabinoid receptor-1 antagonist, AM251, are more robust with age and with high-fat feeding.
Topics: Age Factors; Animals; Appetite Depressants; Body Composition; Dietary Fats; Energy Intake; Hyperphag | 2009 |
The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Chlorocebus aethiops; Circadian Rhyth | 2010 |
Oleamide administered into the nucleus accumbens shell regulates feeding behaviour via CB1 and 5-HT2C receptors.
Topics: Aminopyridines; Animals; Eating; Feeding Behavior; Hyperphagia; Hypothalamus; Indoles; Ketanserin; M | 2010 |
Stimulation of accumbens shell cannabinoid CB(1) receptors by noladin ether, a putative endocannabinoid, modulates food intake and dietary selection in rats.
Topics: Animals; Appetite; Arachidonic Acids; Cannabinoid Receptor Modulators; Diet; Diet, High-Fat; Dietary | 2012 |
Cannabinoid-induced hyperphagia: correlation with inhibition of proopiomelanocortin neurons?
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Body Weight; Cannabinoids | 2007 |