am 251 has been researched along with Huntington Disease in 2 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Covey, DP | 1 |
| Dantrassy, HM | 1 |
| Yohn, SE | 1 |
| Castro, A | 1 |
| Conn, PJ | 1 |
| Mateo, Y | 1 |
| Cheer, JF | 1 |
| Chiodi, V | 1 |
| Uchigashima, M | 1 |
| Beggiato, S | 1 |
| Ferrante, A | 1 |
| Armida, M | 1 |
| Martire, A | 1 |
| Potenza, RL | 1 |
| Ferraro, L | 1 |
| Tanganelli, S | 1 |
| Watanabe, M | 1 |
| Domenici, MR | 1 |
| Popoli, P | 1 |
2 other studies available for am 251 and Huntington Disease
| Article | Year |
|---|---|
Inhibition of endocannabinoid degradation rectifies motivational and dopaminergic deficits in the Q175 mouse model of Huntington's disease.
Topics: Aging; Animals; Apathy; Arachidonic Acids; Benzodioxoles; Conditioning, Operant; Disease Progression | 2018 |
Unbalance of CB1 receptors expressed in GABAergic and glutamatergic neurons in a transgenic mouse model of Huntington's disease.
Topics: Action Potentials; Analysis of Variance; Animals; Benzoxazines; Brain; Disease Models, Animal; Drona | 2012 |