am 251 has been researched along with Glucose Intolerance in 2 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Glucose Intolerance: A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above approximately 200 mg/100 ml plasma at 30-, 60-, or 90-minute during a GLUCOSE TOLERANCE TEST. This condition is seen frequently in DIABETES MELLITUS, but also occurs with other diseases and MALNUTRITION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here we show that administration of the endogenous cannabinoid anandamide or the selective cannabinoid CB1 receptor agonist Arachidonyl-2'-chloroethylamide (ACEA) results in glucose intolerance after a glucose load." | 3.73 | Activation of cannabinoid CB1 receptors induces glucose intolerance in rats. ( Bermúdez-Siva, FJ; Diaz-Molina, FJ; Fuentes, E; Juan-Pico, P; Nadal, A; Rodríguez de Fonseca, F; Sánchez Vera, I; Serrano, A, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bermúdez-Siva, FJ | 1 |
| Serrano, A | 1 |
| Diaz-Molina, FJ | 1 |
| Sánchez Vera, I | 1 |
| Juan-Pico, P | 1 |
| Nadal, A | 1 |
| Fuentes, E | 1 |
| Rodríguez de Fonseca, F | 1 |
| Irwin, N | 1 |
| Hunter, K | 1 |
| Flatt, PR | 1 |
2 other studies available for am 251 and Glucose Intolerance
| Article | Year |
|---|---|
Activation of cannabinoid CB1 receptors induces glucose intolerance in rats.
Topics: Animals; Arachidonic Acids; Blood Glucose; Cannabinoid Receptor Modulators; Endocannabinoids; Glucos | 2006 |
Comparison of independent and combined chronic metabolic effects of GIP and CB1 receptor blockade in high-fat fed mice.
Topics: Animals; Appetite; Area Under Curve; Blood Glucose; Body Weight; Dietary Fats; Drug Evaluation, Prec | 2008 |