am 251 has been researched along with Epilepsy in 7 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study provides electrophysiological evidence that the proconvulsant activity of leptin is mediated, at least in part, by inhibition of cannabinoids in the experimental model of epilepsy." | 3.79 | The role of CB1-receptors in the proconvulsant effect of leptin on penicillin-induced epileptiform activity in rats. ( Agar, E; Alici, SK; Arslan, G; Ayyildiz, M, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arslan, G | 2 |
| Alici, SK | 1 |
| Ayyildiz, M | 4 |
| Agar, E | 4 |
| Kozan, R | 1 |
| Micale, V | 1 |
| Cristino, L | 1 |
| Tamburella, A | 1 |
| Petrosino, S | 1 |
| Leggio, GM | 1 |
| Drago, F | 1 |
| Di Marzo, V | 1 |
| Karr, L | 1 |
| Pan, YZ | 1 |
| Rutecki, PA | 1 |
| Cakil, D | 1 |
| Yildirim, M | 1 |
| Deshpande, LS | 1 |
| Sombati, S | 1 |
| Blair, RE | 1 |
| Carter, DS | 1 |
| Martin, BR | 1 |
| DeLorenzo, RJ | 1 |
7 other studies available for am 251 and Epilepsy
| Article | Year |
|---|---|
The role of CB1-receptors in the proconvulsant effect of leptin on penicillin-induced epileptiform activity in rats.
Topics: Animals; Convulsants; Epilepsy; Infusions, Intraventricular; Leptin; Male; Penicillins; Piperidines; | 2013 |
The interaction between ghrelin and cannabinoid systems in penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Ant | 2014 |
The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Brain; Cannabinoids; Cerebral Cortex; Disease Models, A | 2009 |
Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Anxiety | 2009 |
CB1 receptor antagonism impairs the induction of epileptiform activity by group I metabotropic glutamate receptor activation.
Topics: Animals; Dose-Response Relationship, Drug; Epilepsy; Excitatory Postsynaptic Potentials; Methoxyhydr | 2010 |
The effect of co-administration of the NMDA blocker with agonist and antagonist of CB1-receptor on penicillin-induced epileptiform activity in rats.
Topics: Animals; Arachidonic Acids; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug | 2011 |
Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy.
Topics: Action Potentials; Animals; Animals, Newborn; Benzoxazines; Cells, Cultured; Disease Models, Animal; | 2007 |