am 251 has been researched along with Encephalopathy, Toxic in 5 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| " These toxic effects were attenuated by CB1R knockout or CB1R antagonists." | 1.46 | Genetic or pharmacological depletion of cannabinoid CB1 receptor protects against dopaminergic neurotoxicity induced by methamphetamine in mice. ( Dang, DK; Jang, CG; Jeong, JH; Kim, HC; Ledent, C; Mai, AT; Nabeshima, T; Nah, SY; Onaivi, ES; Shin, EJ; Yamamoto, T, 2017) |
| " Lethality was increased by AM251 with the higher dosage of PO, but no lethality was noted with either dosage of CPO, with or without AM251." | 1.42 | The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats. ( Liu, J; Pope, C, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, D | 1 |
| Liu, X | 1 |
| Dong, X | 1 |
| Zhu, R | 1 |
| Jiang, J | 1 |
| Ye, Y | 1 |
| Jiang, Y | 1 |
| Dang, DK | 1 |
| Shin, EJ | 1 |
| Mai, AT | 1 |
| Jang, CG | 1 |
| Nah, SY | 1 |
| Jeong, JH | 1 |
| Ledent, C | 1 |
| Yamamoto, T | 1 |
| Nabeshima, T | 1 |
| Onaivi, ES | 1 |
| Kim, HC | 1 |
| Liu, J | 1 |
| Pope, C | 1 |
| Touriño, C | 1 |
| Zimmer, A | 1 |
| Valverde, O | 1 |
| Gutierrez-Lopez, MD | 1 |
| Llopis, N | 1 |
| Feng, S | 1 |
| Barrett, DA | 1 |
| O'Shea, E | 1 |
| Colado, MI | 1 |
5 other studies available for am 251 and Encephalopathy, Toxic
| Article | Year |
|---|---|
Cannabinoid 1 Receptor Antagonists Play a Neuroprotective Role in Chronic Alcoholic Hippocampal Injury Related to Pyroptosis Pathway.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Cannabinoid Receptor Agonists; Cannabinoid Recep | 2020 |
Genetic or pharmacological depletion of cannabinoid CB1 receptor protects against dopaminergic neurotoxicity induced by methamphetamine in mice.
Topics: Animals; Apoptosis; Butadienes; Cells, Cultured; Corpus Striatum; Dopamine; Extracellular Signal-Reg | 2017 |
The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Ca | 2015 |
THC Prevents MDMA Neurotoxicity in Mice.
Topics: Animals; Astrocytes; Body Temperature; Dronabinol; Fever; Hallucinogens; Indoles; Mice; Mice, Inbred | 2010 |
Involvement of 2-arachidonoyl glycerol in the increased consumption of and preference for ethanol of mice treated with neurotoxic doses of methamphetamine.
Topics: Alcohol Drinking; Amidohydrolases; Animals; Arachidonic Acids; Central Nervous System Stimulants; Ch | 2010 |