am 251 has been researched along with Diabetes Mellitus, Type 2 in 3 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "CNR1 is upregulated in states of type 2 diabetes and insulin resistance." | 1.46 | Role of cannabinoid receptor 1 in human adipose tissue for lipolysis regulation and insulin resistance. ( Eriksson, JW; Kamble, PG; Katsogiannos, P; Lau Börjesson, J; Pereira, MJ; Sidibeh, CO; Skrtic, S; Sundbom, M; Svensson, MK, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McKillop, AM | 1 |
| Moran, BM | 1 |
| Abdel-Wahab, YH | 1 |
| Flatt, PR | 1 |
| Sidibeh, CO | 1 |
| Pereira, MJ | 1 |
| Lau Börjesson, J | 1 |
| Kamble, PG | 1 |
| Skrtic, S | 1 |
| Katsogiannos, P | 1 |
| Sundbom, M | 1 |
| Svensson, MK | 1 |
| Eriksson, JW | 1 |
| González, C | 1 |
| Herradón, E | 1 |
| Abalo, R | 1 |
| Vera, G | 1 |
| Pérez-Nievas, BG | 1 |
| Leza, JC | 1 |
| Martín, MI | 1 |
| López-Miranda, V | 1 |
3 other studies available for am 251 and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice.
Topics: Animals; Blood Glucose; Calcium; Cannabidiol; Cell Line; Clone Cells; Cyclic AMP; Diabetes Mellitus, | 2013 |
Role of cannabinoid receptor 1 in human adipose tissue for lipolysis regulation and insulin resistance.
Topics: Adipose Tissue; Aged; Dexamethasone; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Fe | 2017 |
Cannabinoid/agonist WIN 55,212-2 reduces cardiac ischaemia–reperfusion injury in Zucker diabetic fatty rats: role of CB2 receptors and iNOS/eNOS.
Topics: Animals; Benzoxazines; Cannabinoids; Cardiotonic Agents; Coronary Vessels; Diabetes Mellitus, Type 2 | 2011 |