am 251 has been researched along with Co-infection in 1 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "2-AG regulates vascular response to NA and increased aortic expression of CB1R is responsible for vascular hyporeactivity to NA in sepsis, and in vitro inhibition of this receptor by AM 251 restored the vascular reactivity." | 3.88 | Endocannabinoid-mediated modulation of Gq protein-coupled receptor mediates vascular hyporeactivity to nor-adrenaline during polymicrobial sepsis. ( Choudhury, S; Garg, SK; Gari, M; Nakade, UP; Sharma, A; Sharma, P; Shukla, A; Singh, P, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, P | 1 |
| Sharma, P | 1 |
| Nakade, UP | 1 |
| Sharma, A | 1 |
| Gari, M | 1 |
| Choudhury, S | 1 |
| Shukla, A | 1 |
| Garg, SK | 1 |
1 other study available for am 251 and Co-infection
| Article | Year |
|---|---|
Endocannabinoid-mediated modulation of Gq protein-coupled receptor mediates vascular hyporeactivity to nor-adrenaline during polymicrobial sepsis.
Topics: Animals; Aorta; Coinfection; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascul | 2018 |