am 251 has been researched along with Chronic Disease in 4 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
Excerpt | Relevance | Reference |
---|---|---|
"Stress contributes to major depressive disorder (MDD) and chronic pain, which affect a significant portion of the global population, but researchers have not clearly determined how these conditions are initiated or amplified by stress." | 1.62 | mGluR5-Mediated eCB Signaling in the Nucleus Accumbens Controls Vulnerability to Depressive-Like Behaviors and Pain After Chronic Social Defeat Stress. ( Han, J; Huang, M; Luo, L; Ma, X; Shi, H; Su, C; Wang, A; Wang, H; Wang, W; Wu, K; Xu, T; Xu, X; Yuan, T, 2021) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (25.00) | 29.6817 |
2010's | 1 (25.00) | 24.3611 |
2020's | 2 (50.00) | 2.80 |
Authors | Studies |
---|---|
Malvestio, RB | 1 |
Medeiros, P | 1 |
Negrini-Ferrari, SE | 1 |
Oliveira-Silva, M | 1 |
Medeiros, AC | 1 |
Padovan, CM | 1 |
Luongo, L | 1 |
Maione, S | 1 |
Coimbra, NC | 1 |
de Freitas, RL | 1 |
Xu, X | 1 |
Wu, K | 1 |
Ma, X | 1 |
Wang, W | 1 |
Wang, H | 1 |
Huang, M | 1 |
Luo, L | 1 |
Su, C | 1 |
Yuan, T | 1 |
Shi, H | 1 |
Han, J | 1 |
Wang, A | 1 |
Xu, T | 1 |
Reich, CG | 1 |
Mihalik, GR | 1 |
Iskander, AN | 1 |
Seckler, JC | 1 |
Weiss, MS | 1 |
Rossi, S | 1 |
De Chiara, V | 1 |
Musella, A | 1 |
Kusayanagi, H | 1 |
Mataluni, G | 1 |
Bernardi, G | 1 |
Usiello, A | 1 |
Centonze, D | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Double-Blind, Placebo-Controlled Study of Dronabinol in Trichotillomania and Other Body Focused Repetitive Behaviors[NCT03530800] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2018-10-01 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
The entire study lasts 10 weeks. Every two weeks subjects will take the NIMH-TSS. The change in scores from baseline to after 10 weeks will be assessed. The scale itself assesses severity of trichotillomania symptoms. The NIMH-TSS score ranges from 0 to 20, with 0 being no symptoms and 20 being the most severe. (NCT03530800)
Timeframe: Assessed every two weeks up to 10 weeks, baseline data reported
Intervention | score on a scale (Mean) |
---|---|
Dronabinol | 12.38 |
Placebo | 10.63 |
The entire study lasts 10 weeks. Every two weeks subjects will take the SP-SAS. The change in scores from baseline to after 10 weeks will be assessed. The scale itself assesses severity of skin-picking symptoms. The SP-SAS score ranges from 0 to 48, with 0 being no symptoms and 48 being the most severe. (NCT03530800)
Timeframe: Assessed every two weeks up to 10 weeks, baseline reported
Intervention | score on a scale (Mean) |
---|---|
Dronabinol | 24.44 |
Placebo | 28.5 |
4 other studies available for am 251 and Chronic Disease
Article | Year |
---|---|
Cannabidiol in the prelimbic cortex modulates the comorbid condition between the chronic neuropathic pain and depression-like behaviour in rats: The role of medial prefrontal cortex 5-HT
Topics: Animals; Cannabidiol; Chronic Disease; Cobalt; Depression; Limbic System; Microinjections; Neuralgia | 2021 |
mGluR5-Mediated eCB Signaling in the Nucleus Accumbens Controls Vulnerability to Depressive-Like Behaviors and Pain After Chronic Social Defeat Stress.
Topics: Animals; Cannabinoid Receptor Antagonists; Chronic Disease; Depressive Disorder, Major; Endocannabin | 2021 |
Adolescent chronic mild stress alters hippocampal CB1 receptor-mediated excitatory neurotransmission and plasticity.
Topics: Animals; Benzoxazines; Chronic Disease; Disease Models, Animal; Excitatory Postsynaptic Potentials; | 2013 |
Chronic psychoemotional stress impairs cannabinoid-receptor-mediated control of GABA transmission in the striatum.
Topics: Animals; Chronic Disease; Corpus Striatum; Dronabinol; Excitatory Amino Acid Antagonists; Excitatory | 2008 |