Page last updated: 2024-10-22

am 251 and Chronic Disease

am 251 has been researched along with Chronic Disease in 4 studies

AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.

Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).

Research Excerpts

ExcerptRelevanceReference
"Stress contributes to major depressive disorder (MDD) and chronic pain, which affect a significant portion of the global population, but researchers have not clearly determined how these conditions are initiated or amplified by stress."1.62mGluR5-Mediated eCB Signaling in the Nucleus Accumbens Controls Vulnerability to Depressive-Like Behaviors and Pain After Chronic Social Defeat Stress. ( Han, J; Huang, M; Luo, L; Ma, X; Shi, H; Su, C; Wang, A; Wang, H; Wang, W; Wu, K; Xu, T; Xu, X; Yuan, T, 2021)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's2 (50.00)2.80

Authors

AuthorsStudies
Malvestio, RB1
Medeiros, P1
Negrini-Ferrari, SE1
Oliveira-Silva, M1
Medeiros, AC1
Padovan, CM1
Luongo, L1
Maione, S1
Coimbra, NC1
de Freitas, RL1
Xu, X1
Wu, K1
Ma, X1
Wang, W1
Wang, H1
Huang, M1
Luo, L1
Su, C1
Yuan, T1
Shi, H1
Han, J1
Wang, A1
Xu, T1
Reich, CG1
Mihalik, GR1
Iskander, AN1
Seckler, JC1
Weiss, MS1
Rossi, S1
De Chiara, V1
Musella, A1
Kusayanagi, H1
Mataluni, G1
Bernardi, G1
Usiello, A1
Centonze, D1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Double-Blind, Placebo-Controlled Study of Dronabinol in Trichotillomania and Other Body Focused Repetitive Behaviors[NCT03530800]Phase 2/Phase 350 participants (Actual)Interventional2018-10-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

NIMH Trichotillomania Symptom Severity Scale (NIMH-TSS)

The entire study lasts 10 weeks. Every two weeks subjects will take the NIMH-TSS. The change in scores from baseline to after 10 weeks will be assessed. The scale itself assesses severity of trichotillomania symptoms. The NIMH-TSS score ranges from 0 to 20, with 0 being no symptoms and 20 being the most severe. (NCT03530800)
Timeframe: Assessed every two weeks up to 10 weeks, baseline data reported

Interventionscore on a scale (Mean)
Dronabinol12.38
Placebo10.63

Skin Picking Symptom Assessment Scale (SP-SAS)

The entire study lasts 10 weeks. Every two weeks subjects will take the SP-SAS. The change in scores from baseline to after 10 weeks will be assessed. The scale itself assesses severity of skin-picking symptoms. The SP-SAS score ranges from 0 to 48, with 0 being no symptoms and 48 being the most severe. (NCT03530800)
Timeframe: Assessed every two weeks up to 10 weeks, baseline reported

Interventionscore on a scale (Mean)
Dronabinol24.44
Placebo28.5

Other Studies

4 other studies available for am 251 and Chronic Disease

ArticleYear
Cannabidiol in the prelimbic cortex modulates the comorbid condition between the chronic neuropathic pain and depression-like behaviour in rats: The role of medial prefrontal cortex 5-HT
    Brain research bulletin, 2021, Volume: 174

    Topics: Animals; Cannabidiol; Chronic Disease; Cobalt; Depression; Limbic System; Microinjections; Neuralgia

2021
mGluR5-Mediated eCB Signaling in the Nucleus Accumbens Controls Vulnerability to Depressive-Like Behaviors and Pain After Chronic Social Defeat Stress.
    Molecular neurobiology, 2021, Volume: 58, Issue:10

    Topics: Animals; Cannabinoid Receptor Antagonists; Chronic Disease; Depressive Disorder, Major; Endocannabin

2021
Adolescent chronic mild stress alters hippocampal CB1 receptor-mediated excitatory neurotransmission and plasticity.
    Neuroscience, 2013, Dec-03, Volume: 253

    Topics: Animals; Benzoxazines; Chronic Disease; Disease Models, Animal; Excitatory Postsynaptic Potentials;

2013
Chronic psychoemotional stress impairs cannabinoid-receptor-mediated control of GABA transmission in the striatum.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Jul-16, Volume: 28, Issue:29

    Topics: Animals; Chronic Disease; Corpus Striatum; Dronabinol; Excitatory Amino Acid Antagonists; Excitatory

2008