Page last updated: 2024-10-22

am 251 and Brain Ischemia

am 251 has been researched along with Brain Ischemia in 4 studies

AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"Global cerebral ischemia in rodents, which mimics cardiac arrest in humans, is associated with a surge in endocannabinoids and increased transmission of dopamine and glutamate leading to excitotoxic cell death."1.43Endocannabinoid CB1 receptor activation upon global ischemia adversely impact recovery of reward and stress signaling molecules, neuronal survival and behavioral impulsivity. ( Azogu, I; de la Tremblaye, PB; Knowles, MD; Plamondon, H, 2016)
"At 24h after the end of the last EA pretreatment, focal cerebral ischemia was induced by middle cerebral artery occlusion for 120min in rats."1.36Involvement of ERK 1/2 activation in electroacupuncture pretreatment via cannabinoid CB1 receptor in rats. ( Chen, S; Du, J; Hu, B; Lu, Y; Ma, L; Peng, Z; Wang, Q; Xiong, L; Zhao, Y; Zhu, X, 2010)
"Two hours after the end of EA pretreatment, focal cerebral ischemia was induced by middle cerebral artery occlusion for 120 minutes in male Sprague-Dawley rats or male C57BL/6 mice."1.35Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid system. ( Chen, S; Du, J; Gou, X; Hu, B; Lu, Y; Peng, Y; Wang, Q; Xiong, L, 2009)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Knowles, MD1
de la Tremblaye, PB1
Azogu, I1
Plamondon, H1
Wang, Q2
Peng, Y1
Chen, S2
Gou, X1
Hu, B2
Du, J2
Lu, Y2
Xiong, L2
Peng, Z1
Zhao, Y1
Ma, L1
Zhu, X1
Rojo, ML1
Söderström, I1
Fowler, CJ1

Other Studies

4 other studies available for am 251 and Brain Ischemia

ArticleYear
Endocannabinoid CB1 receptor activation upon global ischemia adversely impact recovery of reward and stress signaling molecules, neuronal survival and behavioral impulsivity.
    Progress in neuro-psychopharmacology & biological psychiatry, 2016, Apr-03, Volume: 66

    Topics: Animals; Behavior, Animal; Brain Ischemia; Cell Survival; Corticotropin-Releasing Hormone; Impulsive

2016
Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid system.
    Stroke, 2009, Volume: 40, Issue:6

    Topics: Acupuncture Points; Animals; Behavior, Animal; Brain Chemistry; Brain Ischemia; Cannabinoid Receptor

2009
Involvement of ERK 1/2 activation in electroacupuncture pretreatment via cannabinoid CB1 receptor in rats.
    Brain research, 2010, Nov-11, Volume: 1360

    Topics: Animals; Behavior, Animal; Blotting, Western; Brain Ischemia; Butadienes; Electroacupuncture; Enzyme

2010
Residual effects of focal brain ischaemia upon cannabinoid CB(1) receptor density and functionality in female rats.
    Brain research, 2011, Feb-10, Volume: 1373

    Topics: Animals; Autoradiography; Brain; Brain Ischemia; Cyclohexanols; Disease Models, Animal; Estradiol; E

2011