am 251 has been researched along with Brain Ischemia in 4 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Global cerebral ischemia in rodents, which mimics cardiac arrest in humans, is associated with a surge in endocannabinoids and increased transmission of dopamine and glutamate leading to excitotoxic cell death." | 1.43 | Endocannabinoid CB1 receptor activation upon global ischemia adversely impact recovery of reward and stress signaling molecules, neuronal survival and behavioral impulsivity. ( Azogu, I; de la Tremblaye, PB; Knowles, MD; Plamondon, H, 2016) |
| "At 24h after the end of the last EA pretreatment, focal cerebral ischemia was induced by middle cerebral artery occlusion for 120min in rats." | 1.36 | Involvement of ERK 1/2 activation in electroacupuncture pretreatment via cannabinoid CB1 receptor in rats. ( Chen, S; Du, J; Hu, B; Lu, Y; Ma, L; Peng, Z; Wang, Q; Xiong, L; Zhao, Y; Zhu, X, 2010) |
| "Two hours after the end of EA pretreatment, focal cerebral ischemia was induced by middle cerebral artery occlusion for 120 minutes in male Sprague-Dawley rats or male C57BL/6 mice." | 1.35 | Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid system. ( Chen, S; Du, J; Gou, X; Hu, B; Lu, Y; Peng, Y; Wang, Q; Xiong, L, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Knowles, MD | 1 |
| de la Tremblaye, PB | 1 |
| Azogu, I | 1 |
| Plamondon, H | 1 |
| Wang, Q | 2 |
| Peng, Y | 1 |
| Chen, S | 2 |
| Gou, X | 1 |
| Hu, B | 2 |
| Du, J | 2 |
| Lu, Y | 2 |
| Xiong, L | 2 |
| Peng, Z | 1 |
| Zhao, Y | 1 |
| Ma, L | 1 |
| Zhu, X | 1 |
| Rojo, ML | 1 |
| Söderström, I | 1 |
| Fowler, CJ | 1 |
4 other studies available for am 251 and Brain Ischemia
| Article | Year |
|---|---|
Endocannabinoid CB1 receptor activation upon global ischemia adversely impact recovery of reward and stress signaling molecules, neuronal survival and behavioral impulsivity.
Topics: Animals; Behavior, Animal; Brain Ischemia; Cell Survival; Corticotropin-Releasing Hormone; Impulsive | 2016 |
Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid system.
Topics: Acupuncture Points; Animals; Behavior, Animal; Brain Chemistry; Brain Ischemia; Cannabinoid Receptor | 2009 |
Involvement of ERK 1/2 activation in electroacupuncture pretreatment via cannabinoid CB1 receptor in rats.
Topics: Animals; Behavior, Animal; Blotting, Western; Brain Ischemia; Butadienes; Electroacupuncture; Enzyme | 2010 |
Residual effects of focal brain ischaemia upon cannabinoid CB(1) receptor density and functionality in female rats.
Topics: Animals; Autoradiography; Brain; Brain Ischemia; Cyclohexanols; Disease Models, Animal; Estradiol; E | 2011 |