am 251 has been researched along with Brain Edema in 2 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The results showed that JZL lowered brain infarction, neurological disorders, TNF-α and MMP9 more effectively than JZL plus AM251." | 1.48 | JZL184, as a monoacylglycerol lipase inhibitor, down-regulates inflammation in a cannabinoid pathway dependent manner. ( Allahtavakoli, M; Bazmandegan, G; Moghadam-Ahmadi, A; Rahmani, MR; Shamsizadeh, A, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rahmani, MR | 1 |
| Shamsizadeh, A | 1 |
| Moghadam-Ahmadi, A | 1 |
| Bazmandegan, G | 1 |
| Allahtavakoli, M | 1 |
| Lopez-Rodriguez, AB | 1 |
| Siopi, E | 1 |
| Finn, DP | 1 |
| Marchand-Leroux, C | 1 |
| Garcia-Segura, LM | 1 |
| Jafarian-Tehrani, M | 1 |
| Viveros, MP | 1 |
2 other studies available for am 251 and Brain Edema
| Article | Year |
|---|---|
JZL184, as a monoacylglycerol lipase inhibitor, down-regulates inflammation in a cannabinoid pathway dependent manner.
Topics: Animals; Benzodioxoles; Brain Edema; Brain Infarction; Cannabinoids; Down-Regulation; Enzyme Inhibit | 2018 |
CB1 and CB2 cannabinoid receptor antagonists prevent minocycline-induced neuroprotection following traumatic brain injury in mice.
Topics: Animals; Axons; Brain; Brain Edema; Brain Injuries; Cannabinoid Receptor Antagonists; Indoles; Male; | 2015 |