am 251 has been researched along with Body Weight in 26 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To further investigate whether simultaneous pharmacological intervention in the leptin and cannabinoid system might change food and water intake, preferences for palatable foods, and body weight, we have examined the effects of concomitant intraperitoneal administration of leptin and AM 251, a cannabinoid 1 (CB1) receptor antagonist, or cannabidiol (CBD), a plant cannabinoid, in rats maintained on either a high-fat (HF) diet (45% energy from fat) or free-choice (FC) diet consisting of high-sucrose and normal rat chow (83% and 61% energy from carbohydrates, respectively)." | 7.80 | The effects of leptin in combination with a cannabinoid receptor 1 antagonist, AM 251, or cannabidiol on food intake and body weight in rats fed a high-fat or a free-choice high sugar diet. ( Bojanowska, E; Wierucka-Rybak, M; Wolak, M, 2014) |
| "Corticosterone plasma levels, locomotor activity, adrenal gland weight and bone loss were increased in periodontitis and stress groups, and there was also less weight gain." | 7.78 | Anti-inflammatory effect of the endocannabinoid anandamide in experimental periodontitis and stress in the rat. ( De Laurentiis, A; Elverdin, JC; Rettori, E; Rettori, V; Zorrilla Zubilete, M, 2012) |
| " Here, we examine the effect of the CB(1) receptor antagonist AM 251 on food intake and body weight over a prolonged period." | 7.73 | AM 251 produces sustained reductions in food intake and body weight that are resistant to tolerance and conditioned taste aversion. ( Chambers, AP; Koopmans, HS; Pittman, QJ; Sharkey, KA, 2006) |
| "AM6545 is a neutral antagonist, having no effect on cAMP levels in transfected cells and was less centrally penetrant than AM4113, a comparable CB(1) receptor antagonist." | 5.36 | A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents. ( Bedard, H; Chambers, AP; Cluny, NL; Limebeer, CL; Lutz, B; Makriyannis, A; Parker, LA; Sharkey, KA; Vemuri, VK; Wood, JT; Zimmer, A, 2010) |
| " To further investigate whether simultaneous pharmacological intervention in the leptin and cannabinoid system might change food and water intake, preferences for palatable foods, and body weight, we have examined the effects of concomitant intraperitoneal administration of leptin and AM 251, a cannabinoid 1 (CB1) receptor antagonist, or cannabidiol (CBD), a plant cannabinoid, in rats maintained on either a high-fat (HF) diet (45% energy from fat) or free-choice (FC) diet consisting of high-sucrose and normal rat chow (83% and 61% energy from carbohydrates, respectively)." | 3.80 | The effects of leptin in combination with a cannabinoid receptor 1 antagonist, AM 251, or cannabidiol on food intake and body weight in rats fed a high-fat or a free-choice high sugar diet. ( Bojanowska, E; Wierucka-Rybak, M; Wolak, M, 2014) |
| "Corticosterone plasma levels, locomotor activity, adrenal gland weight and bone loss were increased in periodontitis and stress groups, and there was also less weight gain." | 3.78 | Anti-inflammatory effect of the endocannabinoid anandamide in experimental periodontitis and stress in the rat. ( De Laurentiis, A; Elverdin, JC; Rettori, E; Rettori, V; Zorrilla Zubilete, M, 2012) |
| " Here, we examine the effect of the CB(1) receptor antagonist AM 251 on food intake and body weight over a prolonged period." | 3.73 | AM 251 produces sustained reductions in food intake and body weight that are resistant to tolerance and conditioned taste aversion. ( Chambers, AP; Koopmans, HS; Pittman, QJ; Sharkey, KA, 2006) |
| " In a dose-response study, male Wistar rats were injected intraperitoneally with either 1." | 1.37 | Combined stimulation of glucagon-like peptide-1 receptor and inhibition of cannabinoid CB1 receptor act synergistically to reduce food intake and body weight in the rat. ( Bojanowska, E; Radziszewska, E, 2011) |
| "AM6545 is a neutral antagonist, having no effect on cAMP levels in transfected cells and was less centrally penetrant than AM4113, a comparable CB(1) receptor antagonist." | 1.36 | A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents. ( Bedard, H; Chambers, AP; Cluny, NL; Limebeer, CL; Lutz, B; Makriyannis, A; Parker, LA; Sharkey, KA; Vemuri, VK; Wood, JT; Zimmer, A, 2010) |
| " Blood pressure and heart rate remained unchanged after acute or chronic administration of WIN." | 1.35 | Selective lack of tolerance to delayed gastric emptying after daily administration of WIN 55,212-2 in the rat. ( Abalo, R; Cabezos, PA; Castillo, M; Fernández-Pujol, R; González, C; López-Miranda, V; Martín, MI; Vera, G, 2009) |
| "We determined the effect of a cannabinoid CB1 receptor antagonist (AM-251; N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide) on food intake, body weight and adipose tissue mass in Western diet-induced obese (DIO) mice using a chronic, interrupted, oral dosing paradigm." | 1.32 | Antiobesity effects of chronic cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice. ( Black, SC; Hildebrandt, AL; Kelly-Sullivan, DM, 2003) |
| " However, combined oral dosing of nalmefene and subthreshold doses of AM251, a cannabinoid CB1 receptor inverse agonist, led to a significant reduction in food intake in both lean and diet-induced obese (DIO) mice." | 1.32 | Synergistic effects of cannabinoid inverse agonist AM251 and opioid antagonist nalmefene on food intake in mice. ( Chen, RZ; Fong, TM; Huang, RR; MacNeil, DJ; Shen, CP, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (42.31) | 29.6817 |
| 2010's | 15 (57.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Simone, JJ | 1 |
| Baumbach, JL | 1 |
| McCormick, CM | 1 |
| Segev, A | 1 |
| Rubin, AS | 1 |
| Abush, H | 1 |
| Richter-Levin, G | 1 |
| Akirav, I | 1 |
| Radziszewska, E | 2 |
| Wolak, M | 2 |
| Bojanowska, E | 3 |
| Ravussin, Y | 1 |
| Xiao, C | 1 |
| Gavrilova, O | 1 |
| Reitman, ML | 1 |
| Vida, M | 1 |
| Rivera, P | 3 |
| Gavito, AL | 1 |
| Suárez, J | 3 |
| Pavón, FJ | 3 |
| Arrabal, S | 2 |
| Romero-Cuevas, M | 1 |
| Bautista, D | 1 |
| Martínez, A | 1 |
| de Fonseca, FR | 2 |
| Serrano, A | 3 |
| Baixeras, E | 2 |
| Wierucka-Rybak, M | 1 |
| Merroun, I | 1 |
| El Mlili, N | 1 |
| Martinez, R | 1 |
| Porres, JM | 1 |
| Llopis, J | 1 |
| Ahabrach, H | 1 |
| Aranda, P | 1 |
| Sanchez Gonzalez, C | 1 |
| Errami, M | 1 |
| Lopez-Jurado, M | 1 |
| Rabasa, C | 1 |
| Pastor-Ciurana, J | 1 |
| Delgado-Morales, R | 1 |
| Gómez-Román, A | 1 |
| Carrasco, J | 1 |
| Gagliano, H | 1 |
| García-Gutiérrez, MS | 1 |
| Manzanares, J | 1 |
| Armario, A | 1 |
| Lucena, MA | 1 |
| Canduela, MJ | 1 |
| Ramos-Uriarte, A | 1 |
| Decara, J | 1 |
| Vargas, A | 1 |
| Martín-Rufián, M | 1 |
| Márquez, J | 1 |
| Fernández-Llébrez, P | 2 |
| De Roos, B | 1 |
| Grandes, P | 1 |
| Rodríguez de Fonseca, F | 1 |
| Abalo, R | 1 |
| Cabezos, PA | 1 |
| López-Miranda, V | 1 |
| Vera, G | 1 |
| González, C | 1 |
| Castillo, M | 1 |
| Fernández-Pujol, R | 1 |
| Martín, MI | 1 |
| Mathes, CM | 2 |
| Ferrara, M | 2 |
| Rowland, NE | 2 |
| D'Asti, E | 1 |
| Long, H | 1 |
| Tremblay-Mercier, J | 1 |
| Grajzer, M | 1 |
| Cunnane, SC | 1 |
| Di Marzo, V | 1 |
| Walker, CD | 1 |
| Cluny, NL | 1 |
| Vemuri, VK | 1 |
| Chambers, AP | 2 |
| Limebeer, CL | 1 |
| Bedard, H | 1 |
| Wood, JT | 1 |
| Lutz, B | 1 |
| Zimmer, A | 1 |
| Parker, LA | 1 |
| Makriyannis, A | 1 |
| Sharkey, KA | 2 |
| Romero-Zerbo, Y | 1 |
| López-Ávalos, MD | 1 |
| Cifuentes, M | 1 |
| Grondona, JM | 1 |
| Bermúdez-Silva, FJ | 1 |
| Pérez-Martín, M | 1 |
| Cota, D | 1 |
| Marsicano, G | 1 |
| Rettori, E | 1 |
| De Laurentiis, A | 1 |
| Zorrilla Zubilete, M | 1 |
| Rettori, V | 1 |
| Elverdin, JC | 1 |
| Hildebrandt, AL | 1 |
| Kelly-Sullivan, DM | 1 |
| Black, SC | 1 |
| Zhou, D | 1 |
| Shearman, LP | 1 |
| Chen, RZ | 2 |
| Huang, RR | 1 |
| Shen, CP | 1 |
| MacNeil, DJ | 1 |
| Fong, TM | 2 |
| Koopmans, HS | 1 |
| Pittman, QJ | 1 |
| Frassetto, A | 1 |
| Ho, J | 1 |
| Cox, JM | 1 |
| Wagner, EJ | 1 |
| Irwin, N | 2 |
| Hunter, K | 2 |
| Frizzell, N | 1 |
| Flatt, PR | 2 |
1 trial available for am 251 and Body Weight
| Article | Year |
|---|---|
Voluntary exercise augments acute effects of CB1-receptor inverse agonist on body weight loss in obese and lean mice.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Eating; Female; Mice; Mice, Inbred C57BL; Mi | 2004 |
25 other studies available for am 251 and Body Weight
| Article | Year |
|---|---|
Sex-specific effects of CB1 receptor antagonism and stress in adolescence on anxiety, corticosterone concentrations, and contextual fear in adulthood in rats.
Topics: Aging; Animals; Anxiety; Body Weight; Brain Chemistry; Corticosterone; Emotions; Endocannabinoids; E | 2018 |
Cannabinoid receptor activation prevents the effects of chronic mild stress on emotional learning and LTP in a rat model of depression.
Topics: Animals; Avoidance Learning; Benzoxazines; Body Weight; Cannabinoid Receptor Agonists; Cannabinoid R | 2014 |
Concurrent pharmacological modification of cannabinoid-1 and glucagon-like peptide-1 receptor activity affects feeding behavior and body weight in rats fed a free-choice, high-carbohydrate diet.
Topics: Analysis of Variance; Animals; Benzoxazines; Body Weight; Dietary Carbohydrates; Drug Interactions; | 2014 |
Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice.
Topics: Adipose Tissue, Brown; Animals; Biomarkers; Body Composition; Body Weight; Cold Temperature; Deoxygl | 2014 |
CB1 blockade potentiates down-regulation of lipogenic gene expression in perirenal adipose tissue in high carbohydrate diet-induced obesity.
Topics: Adipose Tissue, White; Animals; Body Weight; Diet, High-Fat; Dietary Carbohydrates; Down-Regulation; | 2014 |
The effects of leptin in combination with a cannabinoid receptor 1 antagonist, AM 251, or cannabidiol on food intake and body weight in rats fed a high-fat or a free-choice high sugar diet.
Topics: Animals; Body Weight; Cannabidiol; Cannabinoid Receptor Antagonists; Diet, High-Fat; Dietary Sucrose | 2014 |
Interaction between orexin A and cannabinoid system in the lateral hypothalamus of rats and effects of subchronic intraperitoneal administration of cannabinoid receptor inverse agonist on food intake and the nutritive utilization of protein.
Topics: Animals; Body Weight; Cannabinoid Receptor Agonists; Cannabinoids; Eating; Hypothalamic Area, Latera | 2015 |
Evidence against a critical role of CB1 receptors in adaptation of the hypothalamic-pituitary-adrenal axis and other consequences of daily repeated stress.
Topics: Adaptation, Psychological; Adrenocorticotropic Hormone; Animals; Body Weight; Cannabinoid Receptor A | 2015 |
Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle.
Topics: Animals; Body Weight; Cell Line; Diet; Dietary Carbohydrates; Dihydrolipoamide Dehydrogenase; Electr | 2015 |
Selective lack of tolerance to delayed gastric emptying after daily administration of WIN 55,212-2 in the rat.
Topics: Animals; Benzoxazines; Body Weight; Cannabinoids; Dose-Response Relationship, Drug; Eating; Gastric | 2009 |
Selection of a palatable dietary option is not preferentially reduced by cannabinoid CB1 receptor antagonist AM251 in female C57Bl/6J mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Weight; Choice Behavior; Diet; Dietary Fats; D | 2009 |
Maternal dietary fat determines metabolic profile and the magnitude of endocannabinoid inhibition of the stress response in neonatal rat offspring.
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Analysis of Variance; Animals; Animals, Suckling; Body | 2010 |
A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents.
Topics: Animals; Avoidance Learning; Benzoxazines; Body Weight; Brain; Conditioning, Classical; Cyclic AMP; | 2010 |
Obesity-dependent cannabinoid modulation of proliferation in adult neurogenic regions.
Topics: Adiponectin; Animals; Blood Glucose; Body Weight; Cannabinoid Receptor Modulators; Cell Proliferatio | 2011 |
New fat and new neurons: endocannabinoids control neurogenesis in obesity (Commentary on Rivera et al.).
Topics: Adipose Tissue; Body Weight; Cannabinoid Receptor Modulators; Dietary Fats; Eating; Endocannabinoids | 2011 |
Combined stimulation of glucagon-like peptide-1 receptor and inhibition of cannabinoid CB1 receptor act synergistically to reduce food intake and body weight in the rat.
Topics: Animals; Appetite Depressants; Body Weight; Dose-Response Relationship, Drug; Drug Synergism; Eating | 2011 |
Anti-inflammatory effect of the endocannabinoid anandamide in experimental periodontitis and stress in the rat.
Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents; Arachidonic Acids; Body Weight; Cannabinoid R | 2012 |
Antiobesity effects of chronic cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice.
Topics: Animals; Blood Glucose; Body Weight; Cholesterol; Dietary Fats; Dose-Response Relationship, Drug; Ea | 2003 |
Synergistic effects of cannabinoid inverse agonist AM251 and opioid antagonist nalmefene on food intake in mice.
Topics: Animals; Appetite Regulation; Body Weight; Brain; Cannabinoid Receptor Modulators; Cannabinoids; Dos | 2004 |
AM 251 produces sustained reductions in food intake and body weight that are resistant to tolerance and conditioned taste aversion.
Topics: Animals; Body Weight; Central Nervous System; Drug Tolerance; Eating; Male; Piperidines; Pyrazoles; | 2006 |
Effects of the CB1 cannabinoid receptor inverse agonist AM251 on food intake and body weight in mice lacking mu-opioid receptors.
Topics: Animals; Appetite Regulation; Body Weight; Brain; Brain Chemistry; Cannabinoid Receptor Modulators; | 2006 |
Cannabinoid-induced hyperphagia: correlation with inhibition of proopiomelanocortin neurons?
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Body Weight; Cannabinoids | 2007 |
Antidiabetic effects of sub-chronic administration of the cannabinoid receptor (CB1) antagonist, AM251, in obese diabetic (ob/ob) mice.
Topics: Animals; Blood Glucose; Body Weight; Eating; Female; Hypoglycemic Agents; Insulin; Insulin Resistanc | 2008 |
Comparison of independent and combined chronic metabolic effects of GIP and CB1 receptor blockade in high-fat fed mice.
Topics: Animals; Appetite; Area Under Curve; Blood Glucose; Body Weight; Dietary Fats; Drug Evaluation, Prec | 2008 |
Cannabinoid-1 receptor antagonists reduce caloric intake by decreasing palatable diet selection in a novel dessert protocol in female rats.
Topics: Animals; Appetite Depressants; Body Weight; Diet; Drug Administration Schedule; Eating; Energy Intak | 2008 |