am 251 has been researched along with Blood Pressure, High in 9 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results broadly support the literature showing that the cardiovascular effects of cannabinoids can be exaggerated in hypertension, but highlight the involvement of non-CB(1) receptor-mediated mechanisms in the actions of anandamide." | 3.75 | Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats. ( Gardiner, SM; Ho, WS, 2009) |
| "We conclude that endocannabinoids tonically suppress cardiac contractility in hypertension and that enhancing the CB1-mediated cardiodepressor and vasodilator effects of endogenous anandamide by blocking its hydrolysis can normalize blood pressure." | 3.72 | Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. ( Bátkai, S; Bukoski, RD; Harvey-White, J; Kunos, G; Liu, J; Mackie, K; Offertáler, L; Osei-Hyiaman, D; Pacher, P; Radaeva, S; Rudd, MA, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, GQ | 2 |
| Wang, Z | 1 |
| Zhao, T | 1 |
| Dai, SX | 1 |
| Liu, JM | 1 |
| Jia, BZ | 1 |
| Zhang, Y | 2 |
| Li, Q | 2 |
| Wang, T | 1 |
| Zhang, HP | 1 |
| Ho, WS | 1 |
| Gardiner, SM | 4 |
| Szekeres, M | 1 |
| Nádasy, GL | 1 |
| Turu, G | 1 |
| Soltész-Katona, E | 1 |
| Tóth, ZE | 1 |
| Balla, A | 1 |
| Catt, KJ | 1 |
| Hunyady, L | 1 |
| Iring, A | 1 |
| Ruisanchez, É | 1 |
| Leszl-Ishiguro, M | 1 |
| Horváth, B | 1 |
| Benkő, R | 1 |
| Lacza, Z | 1 |
| Járai, Z | 1 |
| Sándor, P | 1 |
| Di Marzo, V | 1 |
| Pacher, P | 2 |
| Benyó, Z | 1 |
| Bátkai, S | 1 |
| Osei-Hyiaman, D | 1 |
| Radaeva, S | 1 |
| Liu, J | 1 |
| Harvey-White, J | 1 |
| Offertáler, L | 1 |
| Mackie, K | 1 |
| Rudd, MA | 1 |
| Bukoski, RD | 1 |
| Kunos, G | 1 |
| Wheal, AJ | 2 |
| Bennett, T | 2 |
| Randall, MD | 3 |
| O'Sullivan, SE | 1 |
9 other studies available for am 251 and Blood Pressure, High
| Article | Year |
|---|---|
Role of cannabinoid receptor type 1 in rostral ventrolateral medulla in high-fat diet-induced hypertension in rats.
Topics: Animals; Blood Pressure; Diet, High-Fat; Endocannabinoids; Gene Silencing; Heart Rate; Hypertension; | 2018 |
Overactivation of cannabinoid receptor type 1 in rostral ventrolateral medulla promotes cardiovascular responses in spontaneously hypertensive rats.
Topics: Animals; Arachidonic Acids; beta-Arrestin 2; Blood Pressure; Essential Hypertension; Heart Rate; Hyp | 2017 |
Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats.
Topics: Acute Disease; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Blood Pressure | 2009 |
Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors.
Topics: Analgesics; Angiotensin II; Animals; Arteries; Benzoxazines; Endocannabinoids; Endothelium, Vascular | 2012 |
Role of endocannabinoids and cannabinoid-1 receptors in cerebrocortical blood flow regulation.
Topics: Animals; Arachidonic Acids; Arterial Pressure; Cerebrovascular Circulation; Endocannabinoids; Heart | 2013 |
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension.
Topics: Amidohydrolases; Angiotensin II; Animals; Arachidonic Acids; Benzamides; Benzyl Compounds; Blood Pre | 2004 |
Effects of chronic nitric oxide synthase inhibition on the cardiovascular responses to cannabinoids in vivo and in vitro.
Topics: Animals; Arachidonic Acids; Benzoxazines; Blood Pressure; Cannabinoids; Disease Models, Animal; Dose | 2007 |
The in vitro and in vivo cardiovascular effects of Delta9-tetrahydrocannabinol in rats made hypertensive by chronic inhibition of nitric-oxide synthase.
Topics: Animals; Blood Pressure; Dronabinol; Enzyme Inhibitors; Heart Rate; Hypertension; Male; NG-Nitroargi | 2007 |
Cardiovascular effects of cannabinoids in conscious spontaneously hypertensive rats.
Topics: Animals; Arachidonic Acids; Benzoxazines; Blood Pressure; Cannabinoids; Cardiovascular System; Consc | 2007 |