am 251 has been researched along with Blood Poisoning in 3 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A therapeutic option to treat sepsis is to promote intestinal propulsion preventing bacterial stasis, overgrowth and translocation." | 5.35 | Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase. ( d'amico, A; de Filippis, D; de Man, JG; de Winter, BY; Esposito, G; Herman, AG; Iuvone, T; Pelckmans, PA; Steardo, L, 2008) |
| "2-AG regulates vascular response to NA and increased aortic expression of CB1R is responsible for vascular hyporeactivity to NA in sepsis, and in vitro inhibition of this receptor by AM 251 restored the vascular reactivity." | 3.88 | Endocannabinoid-mediated modulation of Gq protein-coupled receptor mediates vascular hyporeactivity to nor-adrenaline during polymicrobial sepsis. ( Choudhury, S; Garg, SK; Gari, M; Nakade, UP; Sharma, A; Sharma, P; Shukla, A; Singh, P, 2018) |
| "A therapeutic option to treat sepsis is to promote intestinal propulsion preventing bacterial stasis, overgrowth and translocation." | 1.35 | Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase. ( d'amico, A; de Filippis, D; de Man, JG; de Winter, BY; Esposito, G; Herman, AG; Iuvone, T; Pelckmans, PA; Steardo, L, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, P | 1 |
| Sharma, P | 1 |
| Nakade, UP | 1 |
| Sharma, A | 1 |
| Gari, M | 1 |
| Choudhury, S | 1 |
| Shukla, A | 1 |
| Garg, SK | 1 |
| Li, YY | 1 |
| Li, YN | 1 |
| Ni, JB | 1 |
| Chen, CJ | 1 |
| Lv, S | 1 |
| Chai, SY | 1 |
| Wu, RH | 1 |
| Yüce, B | 1 |
| Storr, M | 1 |
| de Filippis, D | 1 |
| Iuvone, T | 1 |
| d'amico, A | 1 |
| Esposito, G | 1 |
| Steardo, L | 1 |
| Herman, AG | 1 |
| Pelckmans, PA | 1 |
| de Winter, BY | 1 |
| de Man, JG | 1 |
3 other studies available for am 251 and Blood Poisoning
| Article | Year |
|---|---|
Endocannabinoid-mediated modulation of Gq protein-coupled receptor mediates vascular hyporeactivity to nor-adrenaline during polymicrobial sepsis.
Topics: Animals; Aorta; Coinfection; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascul | 2018 |
Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus.
Topics: Analysis of Variance; Animals; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Electroph | 2010 |
Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase.
Topics: Amidohydrolases; Animals; Cannabidiol; Capsaicin; Gastric Emptying; Gastrointestinal Motility; Intes | 2008 |