am 251 has been researched along with Bile Duct Obstruction in 3 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both opioid and cannabinoid CB(1) receptors may be involved in the dramatic increase in pentylenetetrazole-induced seizure threshold in cholestasis." | 3.74 | Elevation of pentylenetetrazole-induced seizure threshold in cholestatic mice: interaction between opioid and cannabinoid systems. ( Dehpour, AR; Ghasemi, M; Shafaroodi, H, 2008) |
| "Cholestasis is associated with increased activity of the endogenous opioid system that results in analgesia." | 1.35 | The endocannabinoid transport inhibitor AM404 modulates nociception in cholestasis. ( Hasanein, P, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hasanein, P | 1 |
| Yang, YY | 1 |
| Liu, H | 1 |
| Nam, SW | 1 |
| Kunos, G | 1 |
| Lee, SS | 1 |
| Shafaroodi, H | 1 |
| Ghasemi, M | 1 |
| Dehpour, AR | 1 |
3 other studies available for am 251 and Bile Duct Obstruction
| Article | Year |
|---|---|
The endocannabinoid transport inhibitor AM404 modulates nociception in cholestasis.
Topics: Animals; Arachidonic Acids; Biological Transport; Camphanes; Cannabinoid Receptor Modulators; Choles | 2009 |
Mechanisms of TNFalpha-induced cardiac dysfunction in cholestatic bile duct-ligated mice: interaction between TNFalpha and endocannabinoids.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cells, Cultured; Cholestasis; Disease M | 2010 |
Elevation of pentylenetetrazole-induced seizure threshold in cholestatic mice: interaction between opioid and cannabinoid systems.
Topics: Animals; Anticonvulsants; Bile Ducts; Cannabinoid Receptor Modulators; Cholestasis; Disease Models, | 2008 |