am 251 has been researched along with Aura in 7 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study provides electrophysiological evidence that the proconvulsant activity of leptin is mediated, at least in part, by inhibition of cannabinoids in the experimental model of epilepsy." | 3.79 | The role of CB1-receptors in the proconvulsant effect of leptin on penicillin-induced epileptiform activity in rats. ( Agar, E; Alici, SK; Arslan, G; Ayyildiz, M, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arslan, G | 2 |
| Alici, SK | 1 |
| Ayyildiz, M | 4 |
| Agar, E | 4 |
| Kozan, R | 1 |
| Micale, V | 1 |
| Cristino, L | 1 |
| Tamburella, A | 1 |
| Petrosino, S | 1 |
| Leggio, GM | 1 |
| Drago, F | 1 |
| Di Marzo, V | 1 |
| Karr, L | 1 |
| Pan, YZ | 1 |
| Rutecki, PA | 1 |
| Cakil, D | 1 |
| Yildirim, M | 1 |
| Deshpande, LS | 1 |
| Sombati, S | 1 |
| Blair, RE | 1 |
| Carter, DS | 1 |
| Martin, BR | 1 |
| DeLorenzo, RJ | 1 |
7 other studies available for am 251 and Aura
| Article | Year |
|---|---|
The role of CB1-receptors in the proconvulsant effect of leptin on penicillin-induced epileptiform activity in rats.
Topics: Animals; Convulsants; Epilepsy; Infusions, Intraventricular; Leptin; Male; Penicillins; Piperidines; | 2013 |
The interaction between ghrelin and cannabinoid systems in penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Ant | 2014 |
The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Brain; Cannabinoids; Cerebral Cortex; Disease Models, A | 2009 |
Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Anxiety | 2009 |
CB1 receptor antagonism impairs the induction of epileptiform activity by group I metabotropic glutamate receptor activation.
Topics: Animals; Dose-Response Relationship, Drug; Epilepsy; Excitatory Postsynaptic Potentials; Methoxyhydr | 2010 |
The effect of co-administration of the NMDA blocker with agonist and antagonist of CB1-receptor on penicillin-induced epileptiform activity in rats.
Topics: Animals; Arachidonic Acids; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug | 2011 |
Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy.
Topics: Action Potentials; Animals; Animals, Newborn; Benzoxazines; Cells, Cultured; Disease Models, Animal; | 2007 |