am 251 has been researched along with Alloxan Diabetes in 2 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In experimental type 1 diabetes, the CB1 receptor is overexpressed by glomerular podocytes, and blockade of the CB1 receptor ameliorates albuminuria possibly via prevention of nephrin, podocin, and ZO-1 loss." | 3.76 | Cannabinoid receptor 1 blockade ameliorates albuminuria in experimental diabetic nephropathy. ( Barutta, F; Corbelli, A; Di Marzo, V; Gambino, R; Gruden, G; Mastrocola, R; Perin, PC; Pinach, S; Rastaldi, MP, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Morais, H | 1 |
| de Souza, CP | 1 |
| da Silva, LM | 1 |
| Ferreira, DM | 1 |
| Baggio, CH | 1 |
| Vanvossen, AC | 1 |
| Cristina de Carvalho, M | 1 |
| da Silva-Santos, JE | 1 |
| Bertoglio, LJ | 1 |
| Cunha, JM | 1 |
| Zanoveli, JM | 1 |
| Barutta, F | 1 |
| Corbelli, A | 1 |
| Mastrocola, R | 1 |
| Gambino, R | 1 |
| Di Marzo, V | 1 |
| Pinach, S | 1 |
| Rastaldi, MP | 1 |
| Perin, PC | 1 |
| Gruden, G | 1 |
2 other studies available for am 251 and Alloxan Diabetes
| Article | Year |
|---|---|
Anandamide reverses depressive-like behavior, neurochemical abnormalities and oxidative-stress parameters in streptozotocin-diabetic rats: Role of CB1 receptors.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Brain Chemistry; Calcium Channel Blockers; Depression; | 2016 |
Cannabinoid receptor 1 blockade ameliorates albuminuria in experimental diabetic nephropathy.
Topics: Albuminuria; Animals; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diabetic Nep | 2010 |