am 251 has been researched along with Aging in 7 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mechanical allodynia and thermal hyperalgesia were tested on ventral paw for 14 days." | 1.40 | Cannabinoid receptor type 1 antagonist, AM251, attenuates mechanical allodynia and thermal hyperalgesia after burn injury. ( Iwasaki, H; Mao, J; Martyn, JA; Murata, E; Poon, KY; Ueda, M; Wang, S, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Covey, DP | 1 |
| Dantrassy, HM | 1 |
| Yohn, SE | 1 |
| Castro, A | 1 |
| Conn, PJ | 1 |
| Mateo, Y | 1 |
| Cheer, JF | 1 |
| Simone, JJ | 1 |
| Baumbach, JL | 1 |
| McCormick, CM | 1 |
| Ueda, M | 1 |
| Iwasaki, H | 1 |
| Wang, S | 1 |
| Murata, E | 1 |
| Poon, KY | 1 |
| Mao, J | 1 |
| Martyn, JA | 1 |
| Werling, LL | 1 |
| Reed, SC | 1 |
| Wade, D | 1 |
| Izenwasser, S | 1 |
| Tanimura, A | 1 |
| Kawata, S | 1 |
| Hashimoto, K | 1 |
| Kano, M | 1 |
| Aydin, C | 1 |
| Oztan, O | 1 |
| Isgor, C | 1 |
| Pandolfo, P | 1 |
| Pamplona, FA | 1 |
| Prediger, RD | 1 |
| Takahashi, RN | 1 |
7 other studies available for am 251 and Aging
| Article | Year |
|---|---|
Inhibition of endocannabinoid degradation rectifies motivational and dopaminergic deficits in the Q175 mouse model of Huntington's disease.
Topics: Aging; Animals; Apathy; Arachidonic Acids; Benzodioxoles; Conditioning, Operant; Disease Progression | 2018 |
Sex-specific effects of CB1 receptor antagonism and stress in adolescence on anxiety, corticosterone concentrations, and contextual fear in adulthood in rats.
Topics: Aging; Animals; Anxiety; Body Weight; Brain Chemistry; Corticosterone; Emotions; Endocannabinoids; E | 2018 |
Cannabinoid receptor type 1 antagonist, AM251, attenuates mechanical allodynia and thermal hyperalgesia after burn injury.
Topics: Aging; Analgesics, Non-Narcotic; Animals; Burns; Hyperalgesia; Injections, Spinal; Male; Neuroglia; | 2014 |
Chronic nicotine alters cannabinoid-mediated locomotor activity and receptor density in periadolescent but not adult male rats.
Topics: Adolescent; Aging; Analgesics; Animals; Cannabinoids; Cyclohexanols; Dronabinol; Female; Humans; Mal | 2009 |
Not glutamate but endocannabinoids mediate retrograde suppression of cerebellar parallel fiber to Purkinje cell synaptic transmission in young adult rodents.
Topics: Aging; Animals; Calcium; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Cerebell | 2009 |
Nicotine-induced anxiety-like behavior in a rat model of the novelty-seeking phenotype is associated with long-lasting neuropeptidergic and neuroplastic adaptations in the amygdala: effects of the cannabinoid receptor 1 antagonist AM251.
Topics: Aging; Amygdala; Animals; Anxiety; Brain-Derived Neurotrophic Factor; Corticotropin-Releasing Hormon | 2012 |
Increased sensitivity of adolescent spontaneously hypertensive rats, an animal model of attention deficit hyperactivity disorder, to the locomotor stimulation induced by the cannabinoid receptor agonist WIN 55,212-2.
Topics: Aging; Animals; Anxiety; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Benzoxazin | 2007 |