Page last updated: 2024-10-22

am 251 and Aging

am 251 has been researched along with Aging in 7 studies

AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Mechanical allodynia and thermal hyperalgesia were tested on ventral paw for 14 days."1.40Cannabinoid receptor type 1 antagonist, AM251, attenuates mechanical allodynia and thermal hyperalgesia after burn injury. ( Iwasaki, H; Mao, J; Martyn, JA; Murata, E; Poon, KY; Ueda, M; Wang, S, 2014)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (42.86)29.6817
2010's4 (57.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Covey, DP1
Dantrassy, HM1
Yohn, SE1
Castro, A1
Conn, PJ1
Mateo, Y1
Cheer, JF1
Simone, JJ1
Baumbach, JL1
McCormick, CM1
Ueda, M1
Iwasaki, H1
Wang, S1
Murata, E1
Poon, KY1
Mao, J1
Martyn, JA1
Werling, LL1
Reed, SC1
Wade, D1
Izenwasser, S1
Tanimura, A1
Kawata, S1
Hashimoto, K1
Kano, M1
Aydin, C1
Oztan, O1
Isgor, C1
Pandolfo, P1
Pamplona, FA1
Prediger, RD1
Takahashi, RN1

Other Studies

7 other studies available for am 251 and Aging

ArticleYear
Inhibition of endocannabinoid degradation rectifies motivational and dopaminergic deficits in the Q175 mouse model of Huntington's disease.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:10

    Topics: Aging; Animals; Apathy; Arachidonic Acids; Benzodioxoles; Conditioning, Operant; Disease Progression

2018
Sex-specific effects of CB1 receptor antagonism and stress in adolescence on anxiety, corticosterone concentrations, and contextual fear in adulthood in rats.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2018, Volume: 69

    Topics: Aging; Animals; Anxiety; Body Weight; Brain Chemistry; Corticosterone; Emotions; Endocannabinoids; E

2018
Cannabinoid receptor type 1 antagonist, AM251, attenuates mechanical allodynia and thermal hyperalgesia after burn injury.
    Anesthesiology, 2014, Volume: 121, Issue:6

    Topics: Aging; Analgesics, Non-Narcotic; Animals; Burns; Hyperalgesia; Injections, Spinal; Male; Neuroglia;

2014
Chronic nicotine alters cannabinoid-mediated locomotor activity and receptor density in periadolescent but not adult male rats.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2009, Volume: 27, Issue:3

    Topics: Adolescent; Aging; Analgesics; Animals; Cannabinoids; Cyclohexanols; Dronabinol; Female; Humans; Mal

2009
Not glutamate but endocannabinoids mediate retrograde suppression of cerebellar parallel fiber to Purkinje cell synaptic transmission in young adult rodents.
    Neuropharmacology, 2009, Volume: 57, Issue:2

    Topics: Aging; Animals; Calcium; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Cerebell

2009
Nicotine-induced anxiety-like behavior in a rat model of the novelty-seeking phenotype is associated with long-lasting neuropeptidergic and neuroplastic adaptations in the amygdala: effects of the cannabinoid receptor 1 antagonist AM251.
    Neuropharmacology, 2012, Volume: 63, Issue:8

    Topics: Aging; Amygdala; Animals; Anxiety; Brain-Derived Neurotrophic Factor; Corticotropin-Releasing Hormon

2012
Increased sensitivity of adolescent spontaneously hypertensive rats, an animal model of attention deficit hyperactivity disorder, to the locomotor stimulation induced by the cannabinoid receptor agonist WIN 55,212-2.
    European journal of pharmacology, 2007, Jun-01, Volume: 563, Issue:1-3

    Topics: Aging; Animals; Anxiety; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Benzoxazin

2007