am 251 has been researched along with Acute Post-Traumatic Stress Disorder in 4 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Similar to clinical PTSD, approximately 25-30% of rats that undergo cued fear conditioning exhibit impaired extinction learning." | 1.56 | Endocannabinoid modulating drugs improve anxiety but not the expression of conditioned fear in a rodent model of post-traumatic stress disorder. ( Diwan, M; Giacobbe, P; Gidyk, DC; Gouveia, FV; Hamani, C; Lipsman, N; Nobrega, JN; Vimalanathan, A, 2020) |
| "It was suggested that in PTSD, hippocampal-dependent memory is compromised while amygdala-dependent memory is strengthened." | 1.46 | Cannabinoids prevent the differential long-term effects of exposure to severe stress on hippocampal- and amygdala-dependent memory and plasticity. ( Abush, H; Akirav, I; Mizrachi Zer-Aviv, T; Segev, A; Shoshan, N, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vimalanathan, A | 1 |
| Gidyk, DC | 1 |
| Diwan, M | 1 |
| Gouveia, FV | 1 |
| Lipsman, N | 1 |
| Giacobbe, P | 1 |
| Nobrega, JN | 1 |
| Hamani, C | 1 |
| Shoshan, N | 1 |
| Segev, A | 1 |
| Abush, H | 1 |
| Mizrachi Zer-Aviv, T | 2 |
| Akirav, I | 3 |
| Fidelman, S | 1 |
| Lange, R | 1 |
| Hillard, CJ | 1 |
| Ganon-Elazar, E | 1 |
4 other studies available for am 251 and Acute Post-Traumatic Stress Disorder
| Article | Year |
|---|---|
Endocannabinoid modulating drugs improve anxiety but not the expression of conditioned fear in a rodent model of post-traumatic stress disorder.
Topics: Animals; Anxiety; Benzamides; Benzoxazines; Carbamates; Conditioning, Psychological; Disease Models, | 2020 |
Cannabinoids prevent the differential long-term effects of exposure to severe stress on hippocampal- and amygdala-dependent memory and plasticity.
Topics: Amidohydrolases; Amygdala; Animals; Avoidance Learning; Benzamides; Benzoxazines; Bromine; Cannabino | 2017 |
Chronic treatment with URB597 ameliorates post-stress symptoms in a rat model of PTSD.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Basolateral Nuclear Complex; Benzamides; Benzoxazines; | 2018 |
Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress.
Topics: Amygdala; Animals; Anxiety; Avoidance Learning; Benzoxazines; Cannabinoid Receptor Agonists; Cannabi | 2012 |