am 251 has been researched along with Absence Seizure in 20 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Thus, we suggested that the dual FAAH and TRPV1 blockade with N-arachidonoyl-serotonin (AA-5-HT) would be efficacious in inhibiting pentylenetetrazole (PTZ)-induced seizures in mice." | 7.80 | Anticonvulsant effects of N-arachidonoyl-serotonin, a dual fatty acid amide hydrolase enzyme and transient receptor potential vanilloid type-1 (TRPV1) channel blocker, on experimental seizures: the roles of cannabinoid CB1 receptors and TRPV1 channels. ( de Oliveira, AC; Medeiros, DC; Moraes, MF; Moreira, FA; Vilela, LR, 2014) |
| "There was no apparent change of the seizure initiation pattern when kainic acid was coadministrated with AM404, URB597 or AM251." | 5.42 | Attenuation of kainic acid-induced status epilepticus by inhibition of endocannabinoid transport and degradation in guinea pigs. ( Aliev, R; Kitchigina, V; Shubina, L, 2015) |
| " We examined the effect of these metabolites on the threshold of clonic seizures induced by pentylenetetrazole (PTZ)." | 4.02 | The ω-3 endocannabinoid docosahexaenoyl ethanolamide reduces seizure susceptibility in mice by activating cannabinoid type 1 receptors. ( Ghanbari, MM; Loron, AG; Sayyah, M, 2021) |
| " Glutamatergic neurotoxicity, evoked by kainic acid (KA), causes hyperexcitation and acute seizures that result in delayed brain damage." | 3.85 | Endocannabinoid-dependent protection against kainic acid-induced long-term alteration of brain oscillations in guinea pigs. ( Aliev, R; Kitchigina, V; Shubina, L, 2017) |
| " Thus, we suggested that the dual FAAH and TRPV1 blockade with N-arachidonoyl-serotonin (AA-5-HT) would be efficacious in inhibiting pentylenetetrazole (PTZ)-induced seizures in mice." | 3.80 | Anticonvulsant effects of N-arachidonoyl-serotonin, a dual fatty acid amide hydrolase enzyme and transient receptor potential vanilloid type-1 (TRPV1) channel blocker, on experimental seizures: the roles of cannabinoid CB1 receptors and TRPV1 channels. ( de Oliveira, AC; Medeiros, DC; Moraes, MF; Moreira, FA; Vilela, LR, 2014) |
| "Both opioid and cannabinoid CB(1) receptors may be involved in the dramatic increase in pentylenetetrazole-induced seizure threshold in cholestasis." | 3.74 | Elevation of pentylenetetrazole-induced seizure threshold in cholestatic mice: interaction between opioid and cannabinoid systems. ( Dehpour, AR; Ghasemi, M; Shafaroodi, H, 2008) |
| "Ec21a increased resistance to induced seizures in CF1 wild-type mice and mice harboring the SCN1A R1648H human epilepsy mutation." | 1.62 | Allosteric modulation of the cannabinoid 2 receptor confers seizure resistance in mice. ( Escayg, A; Gado, F; Manera, C; Shapiro, L, 2021) |
| "Pretreatment with pioglitazone, as a PPARγ agonist, potentiated the anticonvulsant effects of WIN, while PPARγ antagonist inhibited these anticonvulsant effects partially." | 1.42 | Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2. ( Aghaei, HN; Dehpour, AR; Ebrahimi, A; Gholizadeh, R; Gooshe, M; Mousavizadeh, K; Payandemehr, B; Rahimian, R; Varastehmoradi, B, 2015) |
| "There was no apparent change of the seizure initiation pattern when kainic acid was coadministrated with AM404, URB597 or AM251." | 1.42 | Attenuation of kainic acid-induced status epilepticus by inhibition of endocannabinoid transport and degradation in guinea pigs. ( Aliev, R; Kitchigina, V; Shubina, L, 2015) |
| "Pretreatment with clonidine (0." | 1.39 | The role of α₂-adrenoceptors in the anti-convulsant effects of cannabinoids on pentylenetetrazole-induced seizure threshold in mice. ( Bahremand, A; Dehpour, AR; Moezi, L; Shafaroodi, H, 2013) |
| "Using model of clonic seizure induced by pentylenetetrazole (PTZ) in male NMRI mice, we investigated whether NO is involved in the effects of cannabinoids on the seizure threshold." | 1.35 | Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice. ( Bahremand, A; Dehpour, AR; Ghasemi, M; Nasrabady, SE; Shafaroodi, H, 2009) |
| "Thus, concerning the seizure modulating properties of both classes of receptors this study investigated whether the ultra-low dose opioid antagonist naltrexone influences cannabinoid anticonvulsant effects." | 1.35 | The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice. ( Bahremand, A; Dehpour, AR; Ghasemi, M; Gholizadeh, S; Nasrabady, SE; Shafaroodi, H, 2008) |
| "However, regarding the seizure modulating properties of both classes of receptors this study investigated whether ultra-low dose cannabinoid antagonist AM251 influences cannabinoid anticonvulsant effects." | 1.34 | Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice. ( Bahremand, A; Dehpour, AR; Ghasemi, M; Gholizadeh, S; Shafaroodi, H; Sharifzadeh, M, 2007) |
| "Regarding the seizure-modulating properties of both classes of receptors, the present study examined the possibility of a functional interaction between these receptors." | 1.32 | The interaction of cannabinoids and opioids on pentylenetetrazole-induced seizure threshold in mice. ( Dehpour, AR; Hajrasouliha, AR; Homayoun, H; Moezi, L; Sadeghipour, H; Samini, M; Shafaroodi, H; Tavakoli, S, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 11 (55.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shapiro, L | 1 |
| Gado, F | 1 |
| Manera, C | 1 |
| Escayg, A | 1 |
| Ghanbari, MM | 1 |
| Loron, AG | 1 |
| Sayyah, M | 1 |
| Malyshevskaya, O | 1 |
| Aritake, K | 1 |
| Kaushik, MK | 1 |
| Uchiyama, N | 1 |
| Cherasse, Y | 1 |
| Kikura-Hanajiri, R | 1 |
| Urade, Y | 1 |
| Suemaru, K | 1 |
| Yoshikawa, M | 1 |
| Aso, H | 1 |
| Watanabe, M | 1 |
| Shirzadian, A | 1 |
| Ostadhadi, S | 1 |
| Hassanipour, M | 1 |
| Shafaroodi, H | 7 |
| Khoshnoodi, M | 1 |
| Haj-Mirzaian, A | 1 |
| Sharifzadeh, M | 2 |
| Amiri, S | 1 |
| Ghasemi, M | 5 |
| Dehpour, AR | 8 |
| Moezi, L | 2 |
| Bahremand, A | 4 |
| Vilela, LR | 1 |
| Medeiros, DC | 1 |
| de Oliveira, AC | 1 |
| Moraes, MF | 1 |
| Moreira, FA | 1 |
| Payandemehr, B | 1 |
| Ebrahimi, A | 1 |
| Gholizadeh, R | 1 |
| Rahimian, R | 1 |
| Varastehmoradi, B | 1 |
| Gooshe, M | 1 |
| Aghaei, HN | 1 |
| Mousavizadeh, K | 1 |
| Vigolo, A | 1 |
| Ossato, A | 2 |
| Trapella, C | 2 |
| Vincenzi, F | 2 |
| Rimondo, C | 2 |
| Seri, C | 1 |
| Varani, K | 2 |
| Serpelloni, G | 2 |
| Marti, M | 2 |
| Shubina, L | 2 |
| Aliev, R | 2 |
| Kitchigina, V | 2 |
| Canazza, I | 1 |
| Fantinati, A | 1 |
| De Luca, MA | 1 |
| Margiani, G | 1 |
| Di Rosa, F | 1 |
| Gregori, A | 1 |
| Borea, PA | 1 |
| Nasrabady, SE | 2 |
| Kozan, R | 1 |
| Ayyildiz, M | 1 |
| Agar, E | 1 |
| Samineni, VK | 1 |
| Premkumar, LS | 1 |
| Faingold, CL | 1 |
| Samini, M | 1 |
| Homayoun, H | 1 |
| Sadeghipour, H | 1 |
| Tavakoli, S | 1 |
| Hajrasouliha, AR | 1 |
| Gholizadeh, S | 2 |
| Toscano, CD | 1 |
| Ueda, Y | 1 |
| Tomita, YA | 1 |
| Vicini, S | 1 |
| Bosetti, F | 1 |
20 other studies available for am 251 and Absence Seizure
| Article | Year |
|---|---|
Allosteric modulation of the cannabinoid 2 receptor confers seizure resistance in mice.
Topics: Allosteric Regulation; Animals; Benzeneacetamides; Cannabinoids; Indoles; Male; Mice; Mice, Transgen | 2021 |
The ω-3 endocannabinoid docosahexaenoyl ethanolamide reduces seizure susceptibility in mice by activating cannabinoid type 1 receptors.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Docosahexaenoic Acids; Fat | 2021 |
Natural (∆
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Electroencephalography; Electromyography; Ind | 2017 |
TRPV1 mediates the anticonvulsant effects of acetaminophen in mice.
Topics: Acetaminophen; Acetanilides; Acrylamides; Animals; Anticonvulsants; Bridged Bicyclo Compounds, Heter | 2018 |
Acute foot-shock stress decreased seizure susceptibility against pentylenetetrazole-induced seizures in mice: Interaction between endogenous opioids and cannabinoids.
Topics: Analgesics, Opioid; Animals; Cannabinoid Receptor Antagonists; Convulsants; Disease Models, Animal; | 2018 |
The role of α₂-adrenoceptors in the anti-convulsant effects of cannabinoids on pentylenetetrazole-induced seizure threshold in mice.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoids; Clonidine; Dose-Response Relationship, Dr | 2013 |
Anticonvulsant effects of N-arachidonoyl-serotonin, a dual fatty acid amide hydrolase enzyme and transient receptor potential vanilloid type-1 (TRPV1) channel blocker, on experimental seizures: the roles of cannabinoid CB1 receptors and TRPV1 channels.
Topics: Amidohydrolases; Anilides; Animals; Anticonvulsants; Arachidonic Acids; Cinnamates; Male; Mice; Pent | 2014 |
Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2.
Topics: Anilides; Animals; Anticonvulsants; Benzoxazines; Cannabinoid Receptor Antagonists; Disease Models, | 2015 |
Novel halogenated derivates of JWH-018: Behavioral and binding studies in mice.
Topics: Animals; Binding, Competitive; Cannabinoid Receptor Agonists; Cannabinoids; Catalepsy; CHO Cells; Cr | 2015 |
Attenuation of kainic acid-induced status epilepticus by inhibition of endocannabinoid transport and degradation in guinea pigs.
Topics: Amidohydrolases; Animals; Anticonvulsants; Arachidonic Acids; Benzamides; Biological Transport; Brai | 2015 |
Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on "tetrad", sensorimotor, neurological and neurochemical responses in mice. In vitro and in vivo pharmacological studies.
Topics: Adamantane; Aggression; Animals; Behavior, Animal; Binding, Competitive; Cannabinoid Receptor Agonis | 2016 |
Endocannabinoid-dependent protection against kainic acid-induced long-term alteration of brain oscillations in guinea pigs.
Topics: Amygdala; Animals; Brain; Dentate Gyrus; Endocannabinoids; Guinea Pigs; Hippocampus; Kainic Acid; Ne | 2017 |
Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice.
Topics: Analysis of Variance; Animals; Animals, Inbred Strains; Anticonvulsants; Arachidonic Acids; Arginine | 2009 |
The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Brain; Cannabinoids; Cerebral Cortex; Disease Models, A | 2009 |
Post-ictal analgesia in genetically epilepsy-prone rats is induced by audiogenic seizures and involves cannabinoid receptors in the periaqueductal gray.
Topics: Amnesia, Anterograde; Analgesia; Animals; Epilepsy, Reflex; Female; Male; Pain Threshold; Periaquedu | 2011 |
The interaction of cannabinoids and opioids on pentylenetetrazole-induced seizure threshold in mice.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Recepto | 2004 |
Elevation of pentylenetetrazole-induced seizure threshold in cholestatic mice: interaction between opioid and cannabinoid systems.
Topics: Animals; Anticonvulsants; Bile Ducts; Cannabinoid Receptor Modulators; Cholestasis; Disease Models, | 2008 |
Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Ant | 2007 |
Altered GABAergic neurotransmission is associated with increased kainate-induced seizure in prostaglandin-endoperoxide synthase-2 deficient mice.
Topics: Analysis of Variance; Animals; Autoradiography; Celecoxib; Chromatography, High Pressure Liquid; Cyc | 2008 |
The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoids; Convulsant | 2008 |