am-1241 and Migraine-Disorders

am-1241 has been researched along with Migraine-Disorders* in 1 studies

Other Studies

1 other study(ies) available for am-1241 and Migraine-Disorders

ArticleYear
Activation of CB2 receptors as a potential therapeutic target for migraine: evaluation in an animal model.
    The journal of headache and pain, 2014, Mar-17, Volume: 15

    Experimental animal models of migraine have suggested the existence of interactions between the endocannabinoid system and pain mediation in migraine. Extensive evidence has demonstrated a role for the cannabinoid-1 (CB1) receptor in antinociception. However, recent research suggests that also CB2 receptors, especially located outside the central nervous system, play a role in the perception of pain. Systemic administration of nitroglycerin (NTG) consistently induces spontaneous-like headache attacks in migraneurs; in the rat, systemic NTG induces a condition of hyperalgesia, probably through the activation of cerebral/spinal structures involved in nociceptive transmission. In this study we evaluated the role of CB2 receptors in two animal models of pain that may be relevant for migraine: the tail flick test and the formalin test performed during NTG-induced hyperalgesia.. The study was performed in male Sprague-Dawley rats pre-treated with NTG (10 mg/kg, i.p.) or vehicle (4 hours before) and treated with the CB2 agonist AM1241 o dimethylsulfoxide (DMSO) 60 minutes before both the tail flick test and the formalin test.. AM1241 showed a significant analgesic effect in baseline conditions in both tests. Furthermore, when administered 3 hours after NTG administration, AM1241 at both doses significantly reduced the total number of flinches/shakes during phase II of the test.. These findings suggest that the pharmacological manipulation of the CB2 receptor may represent a potential therapeutic tool for the treatment of migraine.

    Topics: Analgesics; Animals; Cannabinoids; Disease Models, Animal; Drug Delivery Systems; Male; Migraine Disorders; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2

2014