alx-0600 and Duodenal-Diseases

alx-0600 has been researched along with Duodenal-Diseases* in 1 studies

Other Studies

1 other study(ies) available for alx-0600 and Duodenal-Diseases

ArticleYear
De Novo Development of Hamartomatous Duodenal Polyps in a Patient With Short Bowel Syndrome During Teduglutide Therapy: A Case Report.
    JPEN. Journal of parenteral and enteral nutrition, 2018, Volume: 42, Issue:3

    Teduglutide (TG) is approved for the treatment of parenteral nutrition (PN)-dependent adult patients with short bowel syndrome (SBS). Its well-known adverse effect is expedited growth of colon polyps and potential formation of new polyps. Apart from animal studies, de novo development of duodenal polyps in a patient during TG therapy has not been reported in the literature. We report a case of a 71-year-old man with SBS on TG who developed multiple new duodenal polyps that were found incidentally during a diagnostic endoscopy. Furthermore, an accelerated growth of duodenal polyps was noted while on TG therapy, suggesting a potential trophic effect of TG on these polyps. There are no current recommendations for the surveillance of intestinal polyps in patients on TG therapy, but we recommend exercising caution and possible need for surveillance based on this case report.

    Topics: Aged; Duodenal Diseases; Duodenoscopy; Duodenum; Gastrointestinal Agents; Humans; Intestinal Polyps; Male; Parenteral Nutrition; Peptides; Short Bowel Syndrome

2018